Zobrazeno 1 - 10
of 29
pro vyhledávání: '"W. Olieman"'
Autor:
John H. M. Souverijn, Bernadette T. Veering, Anton G. L. Burm, W. Olieman, Jack W. van Kleef, Hilde-Marieken Feyen
Publikováno v:
Anesthesiology. 96:1062-1069
Background Changing plasma protein concentrations may affect the protein binding and pharmacokinetics of drugs in the postoperative period. This study examined the effect of postoperative increases (in response to surgery) in plasma alpha1-acid-glyco
Autor:
Anton G. L. Burm, A. A. Vletter, James G. Bovill, Jette A. Kuipers, F. Boer, Erik Olofsen, W. Olieman
Publikováno v:
Anesthesiology. 90:1146-1157
Background Cardiac output (CO) is likely to influence the pharmacokinetics of anesthetic drugs and should be accounted for in pharmacokinetic models. The influence of CO on the pharmacokinetic parameters of alfentanil in pigs was evaluated using comp
Autor:
Rudolf Stienstra, Anton G. L. Burm, A. D. Van Der Meer, W. Olieman, J. W. Van Kleef, A. A. Vletter
Publikováno v:
Anesthesiology. 90:988-992
Background Prilocaine exists in two stereoisomeric configurations, the enantiomers S(+)- and R(-)-prilocaine. The drug is clinically used as the racemate. This study examined the pharmacokinetics of the enantiomers after intravenous administration of
Autor:
W. Olieman, Rudolf Stienstra, Anton G. L. Burm, B. Zeppenfeldt, M. Mantel, J. W. Van Kleef, P. W. M. Zeijlmans, K. Groen
Publikováno v:
Anesthesia & Analgesia. 86:361-366
We investigated the pharmacokinetics of the enantiomers of bupivacaine and mepivacaine after epidural injection of the racemate of each drug into six surgical patients. After epidural administration of either bupivacaine/HCl (115 mg) or mepivacaine/H
Publikováno v:
Anesthesia & Analgesia. 84:85-89
The pharmacokinetics of R(-)-mepivacaine and S(+)-mepivacaine were investigated in 10 healthy volunteers. The volunteers received racemic mepivacaine, hydrochloride (dose 60 mg) via a 10-min intravenous infusion. Blood samples were collected at gradu
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 678:369-372
A method enabling quantification of R-(-)- and S-(+)-mepivacaine in human plasma in the low nanogram per milliliter range is described. The procedure involves extraction from plasma with diethyl ether, centrifugation, back-extraction into an acidifie
Autor:
Annemiek de Roode, J. Ria Kroon, Rik C. Schoemaker, Joop M. A. van Gerven, James G. Bovill, Adam F. Cohen, W. Olieman, Frank H. M. Engbers
Publikováno v:
Anesthesia and analgesia. 91(5)
UNLABELLED We examined memory during sedation with target-controlled infusions of propofol and midazolam in a double-blinded five-way, cross-over study in 10 volunteers. Each active drug infusion was targeted to sedation level 1 (asleep) and level 4
Autor:
G.M.A. Van Gerven, James G. Bovill, W. Olieman, A. De Roode, Frank H. M. Engbers, Adam F. Cohen, Rik C. Schoemaker
Publikováno v:
Memory and Awareness in Anaesthesia IV.
Publikováno v:
Anesthesiology. 91(6)
The principal site for elimination of propofol is the liver. The clearance of propofol exceeds hepatic blood flow; therefore, extrahepatic clearance is thought to contribute to its elimination. This study examined the pulmonary kinetics of propofol u
Publikováno v:
Anesthesiology. 90(4)
Prilocaine exists in two stereoisomeric configurations, the enantiomers S(+)- and R(-)-prilocaine. The drug is clinically used as the racemate. This study examined the pharmacokinetics of the enantiomers after intravenous administration of the racema