Výsledky vyhledávání - "W. Nicol Keith"

Akademický článek

A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation

Autor: Alan E. Bilsland, Yu Liu, Andrew Turnbull, David Sumpton, Katrina Stevenson, Claire J. Cairney, Susan M. Boyd, Jon Roffey, David Jenkinson, W. Nicol Keith

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 9, Pp 893-907 (2019)

Telomere signaling and metabolic dysfunction are hallmarks of cell aging. New agents targeting these processes might provide therapeutic opportunities, including chemoprevention strategies against cancer predisposition. We report identification and c

Externí odkaz: https://doaj.org/article/936206170ac349faab43d8b1ddaedfcd

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Akademický článek

Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks

Autor: Alan E. Bilsland, Angelo Pugliese, Yu Liu, John Revie, Sharon Burns, Carol McCormick, Claire J. Cairney, Justin Bower, Martin Drysdale, Masashi Narita, Mahito Sadaie, W. Nicol Keith

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 9, Pp 704-715 (2015)

Cellular senescence is a barrier to tumorigenesis in normal cells, and tumor cells undergo senescence responses to genotoxic stimuli, which is a potential target phenotype for cancer therapy. However, in this setting, mixed-mode responses are common

Externí odkaz: https://doaj.org/article/f63495499283424f8b4feb22d3460e78

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Akademický článek

Immortalization of T-Cells Is Accompanied by Gradual Changes in CpG Methylation Resulting in a Profile Resembling a Subset of T-Cell Leukemias

Autor: Sofie Degerman, Mattias Landfors, Jan Konrad Siwicki, John Revie, Magnus Borssén, Emma Evelönn, Erik Forestier, Krystyna H. Chrzanowska, Patrik Rydén, W. Nicol Keith, Göran Roos

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 7, Pp 606-615 (2014)

We have previously described gene expression changes during spontaneous immortalization of T-cells, thereby identifying cellular processes important for cell growth crisis escape and unlimited proliferation. Here, we analyze the same model to investi

Externí odkaz: https://doaj.org/article/45a9461da5ed43f1b09b8e7969e6aabe

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Akademický článek

Properties of a Telomerase-Specific Cre/Lox Switch for Transcriptionally Targeted Cancer Gene Therapy

Autor: Alan E. Bilsland, Aileen Fletcher-Monaghan, W. Nicol Keith

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 11, Pp 1020-1029 (2005)

Telomerase expression represents a good target for cancer gene therapy. The promoters of the core telomerase catalytic [human telomerase reverse transcriptase (hTERT)] and RNA [human telomerase RNA (hTR)] subunits show selective activity in cancer ce

Externí odkaz: https://doaj.org/article/c08d137303514853a723ca27f3e65ce6

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Akademický článek

The hTERT and hTERC Telomerase Gene Promoters Are Activated by the Second Exon of the Adenoviral Protein, E1 A, Identifying the Transcriptional Corepressor CtBP as a Potential Rearessor of Both Genes

Autor: Rosalind M. Glasspool, Sharon Burns, Stacey F. Hoare, Catharina Svensson, W. Nicol Keith

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 6, Pp 614-622 (2005)

Telomerase plays a role in the unlimited replicative capacity of the majority of cancer cells and provides a potential anticancer target. The regulation of telomerase is complex but transcriptional control of its two essential components, hTERC (RNA

Externí odkaz: https://doaj.org/article/3dde767e5f9a46b198f16621462b083d

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Akademický článek

Mapping of the Gene for the Human Telomerase Reverse Transcriptase, hTERT, to Chromosome 5p15.33 by Fluorescence in Situ Hybridization

Autor: Lisa A. Bryce, Norma Morrisont, Stacey F. Hoare, Sharon Muir, W. Nicol Keith

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 2, Iss 3, Pp 197-201 (2000)

Telomerase, the enzyme that maintains the ends of chromosomes, is absent from the majority of somatic cells but is present and active in most tumours. The gene for the reverse transcriptase component of telomerase (hTERT) has recently been identified

Externí odkaz: https://doaj.org/article/437540c1342040fb8c2a32ef0689d029

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Akademický článek

Activation of Telomerase RNA Gene Promoter Activity by NF-Y, Sp1, and the Retinoblastoma Protein and Repression by Sp3

Autor: Jiang-Qin Zhao, Rosalind M. Glasspool, Stacey F. Hoare, Alan Bilsland, Istvan Szatmari, W. Nicol Keith

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 2, Iss 6, Pp 531-539 (2000)

Expression of the human telomerase RNA component gene, hTERC is essential for telomerase activity. The hTERC gene is expressed during embryogenesis and then downregulated during normal development, leaving most adult somatic cells devoid of hTERC exp

Externí odkaz: https://doaj.org/article/82c78de49e87417faf770f10ea51b8ad

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