Zobrazeno 1 - 10
of 191
pro vyhledávání: '"W. Neuse"'
Publikováno v:
International Journal of Polymeric Materials and Polymeric Biomaterials. 68:452-462
Literature reports several recent attempts to load a single drug onto one carrier to improve drug efficacy. An ideal anticancer drug would result from anchoring two anticancer drugs on a single car...
Publikováno v:
Journal of Inorganic and Organometallic Polymers and Materials. 25:367-375
The present study reports the preparation and preliminary biological activity results of co-conjugates of platinum ferrocene based drugs by using a novel synthetic route for the incorporation of ferrocene into the carrier. The Fe content obtained by
Publikováno v:
Journal of Inorganic and Organometallic Polymers and Materials. 24:302-314
In this research, the incorporation of ferrocenecarboxyaldehyde, 3-ferrocenylprop-2-enal and acetylferrocene to a polymeric backbone via hydrazone bond to form conjugates and co-conjugates was demonstrated. The conjugates and co-conjugates containing
Publikováno v:
Journal of Biomedical Materials Research Part A. 102:1941-1949
In this research, aminoquinoline compounds were synthesized, characterized, and incorporated into water-soluble polymers to form conjugates. The conjugates were characterized by X-ray diffraction, thermal gravimetric analysis, scanning electron micro
Publikováno v:
Journal of Inorganic and Organometallic Polymers and Materials. 22:886-891
The current cancer chemotherapy often results in high toxicity, drug resistance and some other side effects. Multidrug chemotherapy has been found to reduce the side effects associated with the currently used chemotherapy. In this research, we have d
Publikováno v:
Journal of Inorganic and Organometallic Polymers and Materials. 22:429-438
Some members of 4-aminoquinolines and 8-aminoquinolines have been found to provide adjuvant effects when used in combination with anti-cancer drugs. The clinical co-administration of active anti-cancer drugs with other drugs acting as potentiating ag
Publikováno v:
Journal of Inorganic and Organometallic Polymers and Materials. 22:423-428
Novel anticancer “as reported by Neuse (Synthetic Polymers as Drug-Delivery Vehicles in Medicine, Hindawi Publishing Corporation, Cairo, 2008) and Mufula (Macromolecular Derivatives of Methotrexate and Ferrocene as Potential Prodrugs in Cancer Chem
Autor:
Alain I. Mufula, Eberhard W. Neuse
Publikováno v:
Journal of Inorganic and Organometallic Polymers and Materials. 22:134-148
Most of the polyaspartamide carrier polymers synthesized in this program, were conjugated with methotrexate (MTX) and with organoiron compound (ferrocene), whereas other polyamides were conjugated with 1,2-diaminocyclohexanediaquaplatinum(II)dinitrat
Autor:
Eberhard W. Neuse, Alain I. Mufula
Publikováno v:
Journal of Inorganic and Organometallic Polymers and Materials. 21:511-526
Several drug-carrier polymers were synthesized in this program, including polyaspartamides, ester-amine condensation polymers, and polyamidoamines (PAAs). Functionalized polyaspartamides were obtained in 46–73% yield by an aminolytic ring-opening p
Publikováno v:
Journal of Inorganic and Organometallic Polymers and Materials. 21:336-345
In the chemotherapy of cancerous diseases, the clinical co-administration of an active anti-tumor drug with other compounds acting as potentiating agents or adjuvants has demonstrated considerable merits in comparison with single-drug administration.