Zobrazeno 1 - 10
of 33
pro vyhledávání: '"W. Michael Seganish"'
Autor:
Luqia Hou, Mohit Kumar, Priti Anand, Yinhong Chen, Nesrine El-Bizri, Chad J. Pickens, W. Michael Seganish, Sakthivel Sadayappan, Gayathri Swaminath
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Cardiac myosin binding protein-C (cMyBP-C) is an important regulator of sarcomeric function. Reduced phosphorylation of cMyBP-C has been linked to compromised contractility in heart failure patients. Here, we used previously published cMyBP-
Externí odkaz:
https://doaj.org/article/b15ebb87cdaf439295dcec183101f5d9
Autor:
Victor W. Mak, Akash M. Patel, Rose Yen, Jennifer Hanisak, Yeon-Hee Lim, Jianming Bao, Rong Zheng, W. Michael Seganish, Yang Yu, David R. Healy, Aimie Ogawa, Zhao Ren, Aileen Soriano, Grigori P. Ermakov, Maribel Beaumont, Essam Metwally, Alan C. Cheng, Andreas Verras, Thierry Fischmann, Matthias Zebisch, H. Leonardo Silvestre, Paul A. McEwan, John Barker, Paul Rearden, Thomas J. Greshock
Publikováno v:
Journal of Medicinal Chemistry. 65:10318-10340
Activation of PKG1α is a compelling strategy for the treatment of cardiovascular diseases. As the main effector of cyclic guanosine monophosphate (cGMP), activation of PKG1α induces smooth muscle relaxation in blood vessels, lowers pulmonary blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509e1acecf452693747dc2e5a314142e
https://doi.org/10.1021/acs.jmedchem.1c02109
https://doi.org/10.1021/acs.jmedchem.1c02109
Autor:
Paul Tawa, Lei Zhang, Essam Metwally, Yan Hou, Mark A. McCoy, W. Michael Seganish, Rumin Zhang, Emily Frank, Payal Sheth, Jennifer Hanisak, Christopher Sondey, David Bauman, Aileen Soriano
Publikováno v:
The Journal of biological chemistry. 298(9)
cGMP-dependent protein kinase (PKG) represents a compelling drug target for treatment of cardiovascular diseases. PKG1 is the major effector of beneficial cGMP signaling which is involved in smooth muscle relaxation and vascular tone, inhibition of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c725ecfa9c2f786568a217b32fbd8e
https://pubmed.ncbi.nlm.nih.gov/35868561
https://pubmed.ncbi.nlm.nih.gov/35868561
Autor:
Andreas Verras, Lei Zhang, Aileen Soriano, Gregory O'Donnell, Emily Frank, Andrea D. Basso, David J. Bell, Paul Tawa, W. Michael Seganish, Jennifer Hanisak, Yang Yu, Gregory C. Adam, David R. Bauman
Publikováno v:
ACS Med Chem Lett
[Image: see text] PKG1α is a central node in cGMP signaling. Current therapeutics that look to activate this pathway rely on elevation of cGMP levels and subsequent activation of PKG1α. Direct activation of PKG1α could potentially drive additional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b05d721292d7270027b12125728c49
https://europepmc.org/articles/PMC8365999/
https://europepmc.org/articles/PMC8365999/
Autor:
Christopher Sondey, Theirry Fischmann, Kristine Devito, Haiquin Tang, W. Michael Seganish, Rui Zhang, Jennifer Hanisak, Hon-Chung Tsui, Deen Tulshian, Daniel Lundell, Charles G. Garlisi, William T. McElroy, Xiaoda Niu, James Fossetta, James R. Tata
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4250-4255
IRAK4 has been identified as potential therapeutic target for inflammatory and autoimmune diseases. Herein we report the identification and initial SAR studies of a new class of pyrazole containing IRAK4 inhibitors designed to expand chemical diversi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f36bde751943a6860892af80d72d0b9
https://doi.org/10.1016/j.bmcl.2016.07.048
https://doi.org/10.1016/j.bmcl.2016.07.048
Heart failure is a complex syndrome in which the heart is unable to deliver sufficient blood to meet the metabolic needs of organs throughout the body in the presence of normal filling pressures. Despite approval of multiple drugs for treating heart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce9d94e056725b5a73c7399250b8a64c
https://doi.org/10.1016/b978-0-12-409547-2.12434-5
https://doi.org/10.1016/b978-0-12-409547-2.12434-5
Autor:
W. Michael Seganish
Publikováno v:
Expert opinion on therapeutic patents. 26(8)
Introduction: IRAK4 is located proximal to TLR/IL-1 receptors, and in preclinical studies, inhibits downstream signaling from these receptors. The development of novel small molecule inhibitors of this kinase has the potential to lead to new therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180a4045c03c22538de8f091b9a8f2ac
https://pubmed.ncbi.nlm.nih.gov/27310003
https://pubmed.ncbi.nlm.nih.gov/27310003
Publikováno v:
Chemistry - A European Journal. 18:2961-2971
In this manuscript, we report the full account of our efforts to couple the northern and the southern building blocks, whose synthesis were described in the preceding paper, along with the modifications required which ultimately lead to a successful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ae63b661792a08d59e8b967290e943
https://doi.org/10.1002/chem.201102899
https://doi.org/10.1002/chem.201102899
Publikováno v:
Chemistry - A European Journal. 18:2948-2960
The first stage of the development of a synthetic route for the total synthesis of laulimalide (1) is described. Our retrosynthetic analysis envisioned a novel macrocyclization route to the natural product using a Ru-catalyzed alkene-alkyne coupling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a48a0bb274ff9f51e9e50f8ab2028f
https://doi.org/10.1002/chem.201102898
https://doi.org/10.1002/chem.201102898
Autor:
Norma C. Holter, W. Michael Seganish
Publikováno v:
Journal of Business Case Studies (JBCS). 4:43-50
This article introduces an innovative way to teach the Enterprise Risk Management (ERM) Integrated Framework (as developed by COSO), while at the same time informs the student of a real personal risk -- identity theft. This example of assessing and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62c2933da2dbb207e6632f5369a049d1
https://doi.org/10.19030/jbcs.v4i6.4787
https://doi.org/10.19030/jbcs.v4i6.4787