Zobrazeno 1 - 10
of 373
pro vyhledávání: '"W. Metz"'
Autor:
Stefan W. Metz, Ashlie Thomas, Alex Brackbill, John Forsberg, Michael J. Miley, Cesar A. Lopez, Helen M. Lazear, Shaomin Tian, Aravinda M. de Silva
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
Many human antibodies that neutralize Zika virus recognize quaternary epitopes on the envelope (E) protein. Here, Metz et al. engineer stable recombinant homodimers of Zika virus E protein and show that it induces neutralizing antibodies in mice that
Externí odkaz:
https://doaj.org/article/e36de0074bf54f54a8a6e3c49a2d1323
Autor:
Stefan W. Metz, Ashlie Thomas, Laura White, Mark Stoops, Markus Corten, Holger Hannemann, Aravinda M. de Silva
Publikováno v:
Virology Journal, Vol 15, Iss 1, Pp 1-10 (2018)
Abstract Background The 4 dengue serotypes (DENV) are mosquito-borne pathogens that are associated with severe hemorrhagic disease. DENV particles have a lipid bilayer envelope that anchors two membrane glycoproteins prM and E. Two E-protein monomers
Externí odkaz:
https://doaj.org/article/cec765ff6cab4d9cb974eae17e399d64
Autor:
Stefan W. Metz, Emily N. Gallichotte, Alex Brackbill, Lakshmanane Premkumar, Michael J. Miley, Ralph Baric, Aravinda M. de Silva
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Zika virus (ZIKV) and the 4 dengue virus (DENV) serotypes are mosquito-borne Flaviviruses that are associated with severe neuronal and hemorrhagic syndromes. The mature flavivirus infectious virion has 90 envelope (E) protein homo-dimers tha
Externí odkaz:
https://doaj.org/article/124462baa03a44d88e19b793bcc298bf
Autor:
Emily N. Gallichotte, Ellen F. Young, Thomas J. Baric, Boyd L. Yount, Stefan W. Metz, Matthew C. Begley, Aravinda M. de Silva, Ralph S. Baric
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Zika virus (ZIKV) is a flavivirus that is structurally highly similar to the related viruses, dengue virus (DENV), West Nile virus, and yellow fever virus. ZIKV causes an acute infection that often results in mild symptoms but that can cause
Externí odkaz:
https://doaj.org/article/f659dd33a20641e28415e64c39b45e5e
Autor:
Stefan W Metz, Ashlie Thomas, Alex Brackbill, Yi Xianwen, Michele Stone, Katie Horvath, Michael J Miley, Chris Luft, Joseph M DeSimone, Shaomin Tian, Aravinda M de Silva
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 9, p e0006793 (2018)
Dengue virus (DENV) is the causative agent of dengue fever and dengue hemorrhagic shock syndrome. Dengue vaccine development is challenging because of the need to induce protection against four antigenically distinct DENV serotypes. Recent studies in
Externí odkaz:
https://doaj.org/article/a436f753500142288d12edd9e04f8822
Autor:
Stefan W Metz, Shaomin Tian, Gabriel Hoekstra, Xianwen Yi, Michelle Stone, Katie Horvath, Michael J Miley, Joseph DeSimone, Chris J Luft, Aravinda M de Silva
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 10, p e0005071 (2016)
Dengue virus (DENV) is the causative agent of dengue fever and dengue hemorrhagic fever. The virus is endemic in over 120 countries, causing over 350 million infections per year. Dengue vaccine development is challenging because of the need to induce
Externí odkaz:
https://doaj.org/article/185619cc0aa746ac9030670c9a9e6064
Autor:
Tessy A. H. Hick, Corinne Geertsema, Maurice G. L. Henquet, Dirk E. Martens, Stefan W. Metz, Gorben P. Pijlman
Publikováno v:
Processes, Vol 10, Iss 162, p 162 (2022)
Processes, 10(1)
Processes; Volume 10; Issue 1; Pages: 162
Processes 10 (2022) 1
Processes, 10(1)
Processes; Volume 10; Issue 1; Pages: 162
Processes 10 (2022) 1
Chikungunya virus (CHIKV) is a rapidly emerging mosquito-borne virus that causes a severe febrile illness with long-lasting arthralgia in humans. As there is no vaccine to protect humans and limit CHIKV epidemics, the virus continues to be a global p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0216500ccec442d8d72dc6d57ea08b
https://www.mdpi.com/2227-9717/10/1/162
https://www.mdpi.com/2227-9717/10/1/162
Publikováno v:
Vaccine. 40(22)
Chikungunya virus (CHIKV), an arbovirus from the Alphavirus genus, causes sporadic outbreaks and epidemics and can cause acute febrile illness accompanied by severe long-term arthralgias. Over 20 CHIKV vaccine candidates have been developed over the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d5d45198e9cb6bec6a9fcbbfb0bc8d
https://pubmed.ncbi.nlm.nih.gov/35459557
https://pubmed.ncbi.nlm.nih.gov/35459557
Autor:
Michael K. McCracken, Stephan T. Kudlacek, Devina J Thiono, Jack Maguire, Aravinda M. de Silva, Thanh T. N. Phan, Alexander Matthew Payne, Sandrine Soman, Nathan I. Nicely, Richard G. Jarman, Shu Zhang, Ashutosh Tripathy, Stefan W. Metz, Joseph S. Harrison, Lawrence J. Forsberg, Lakshmanane Premkumar, Gregory D. Gromowski, Ian Seim, Brian Kuhlman, Shaomin Tian
Publikováno v:
Science Advances
Description
A stabilized dimer of the surface protein from dengue virus has been engineered to elicit antibodies that neutralize the virus.
Dengue virus (DENV) is a worldwide health burden, and a safe vaccine is needed. Neutralizing antibod
A stabilized dimer of the surface protein from dengue virus has been engineered to elicit antibodies that neutralize the virus.
Dengue virus (DENV) is a worldwide health burden, and a safe vaccine is needed. Neutralizing antibod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad498c63dcd291c5cbf570e9ffb26d5
https://doi.org/10.1126/sciadv.abg4084
https://doi.org/10.1126/sciadv.abg4084
Autor:
Stefan W Metz, Joy Gardner, Corinne Geertsema, Thuy T Le, Lucas Goh, Just M Vlak, Andreas Suhrbier, Gorben P Pijlman
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 3, p e2124 (2013)
The emerging arthritogenic, mosquito-borne chikungunya virus (CHIKV) causes severe disease in humans and represents a serious public health threat in countries where Aedes spp mosquitoes are present. This study describes for the first time the succes
Externí odkaz:
https://doaj.org/article/1cb27c031e31450cabba3c0ff80f2227