Zobrazeno 1 - 10
of 490
pro vyhledávání: '"W. Messer"'
Autor:
Jie Du, Weizhe Chen, Xihua Jia, Xuejiao Xu, Emily Yang, Ruizhi Zhou, Yuqi Zhang, Matt Metzloff, Philipp W. Messer, Jackson Champer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Gene drive systems could be a viable strategy to prevent pathogen transmission or suppress vector populations by propagating drive alleles with super-Mendelian inheritance. CRISPR-based homing gene drives convert wild type alleles into drive
Externí odkaz:
https://doaj.org/article/7bcc28e1cfff46859f2097068c4cce2c
Autor:
Matthew Metzloff, Emily Yang, Sumit Dhole, Andrew G. Clark, Philipp W. Messer, Jackson Champer
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Homing gene drives hold great promise for the genetic control of natural populations. However, current homing systems are capable of spreading uncontrollably between populations connected by even marginal levels of migration. This
Externí odkaz:
https://doaj.org/article/82e027ed2a8643468a7c8a40fd4bfad1
Publikováno v:
eLife, Vol 11 (2022)
Recent experiments have produced several Anopheles gambiae homing gene drives that disrupt female fertility genes, thereby eventually inducing population collapse. Such drives may be highly effective tools to combat malaria. One such homing drive, ba
Externí odkaz:
https://doaj.org/article/6ffbd00771524b96a5b442b49d108bb5
Autor:
Anna M Langmüller, Jackson Champer, Sandra Lapinska, Lin Xie, Matthew Metzloff, Samuel E Champer, Jingxian Liu, Yineng Xu, Jie Du, Andrew G Clark, Philipp W Messer
Publikováno v:
eLife, Vol 11 (2022)
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 provides a highly efficient and flexible genome editing technology with numerous potential applications ranging from gene therapy to population control. Some proposed application
Externí odkaz:
https://doaj.org/article/ff04aa591a7841878d85a89619cb13ba
Publikováno v:
Evolutionary Applications, Vol 14, Iss 4, Pp 1052-1069 (2021)
Abstract CRISPR gene drive systems offer a mechanism for transmitting a desirable transgene throughout a population for purposes ranging from vector‐borne disease control to invasive species suppression. In this simulation study, we assess the perf
Externí odkaz:
https://doaj.org/article/0198ba3d5de541b5b432d81d0521fa53
Autor:
Emily Yang, Matthew Metzloff, Anna M Langmüller, Xuejiao Xu, Andrew G Clark, Philipp W Messer, Jackson Champer
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 12, Iss 6 (2022)
AbstractGene drives are engineered alleles that can bias inheritance in their favor, allowing them to spread throughout a population. They could potentially be used to modify or suppress pest populations, such as mosquitoes that spread diseases. CRIS
Externí odkaz:
https://doaj.org/article/c93377ff98914cc5924aac77126ae869
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 9, Pp 3213-3227 (2020)
Evolve and resequence (E&R) experiments, in which artificial selection is imposed on organisms in a controlled environment, are becoming an increasingly accessible tool for studying the genetic basis of adaptation. Previous work has assessed how diff
Externí odkaz:
https://doaj.org/article/a73b43d44f90423eb8f8aadfc861994f
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-17 (2020)
Abstract Background CRISPR gene drive systems allow the rapid spread of a genetic construct throughout a population. Such systems promise novel strategies for the management of vector-borne diseases and invasive species by suppressing a target popula
Externí odkaz:
https://doaj.org/article/e195093c80d74860962611abe6e080f3
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
CRISPR homing gene drives are highly invasive and can fail due to the rapid evolution of resistance. Here the authors present TARE drive, inspired by naturally occurring selfish genetic elements, which is less vulnerable to resistance and can potenti
Externí odkaz:
https://doaj.org/article/8d0e866433494a27b44fe774762e8847
Autor:
Samuel E Champer, Nathan Oakes, Ronin Sharma, Pablo García-Díaz, Jackson Champer, Philipp W Messer
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 12, p e1009660 (2021)
Invasive rodent populations pose a threat to biodiversity across the globe. When confronted with these invaders, native species that evolved independently are often defenseless. CRISPR gene drive systems could provide a solution to this problem by sp
Externí odkaz:
https://doaj.org/article/4f53ed85976e438cb7aa70199b366a43