Zobrazeno 1 - 10
of 186
pro vyhledávání: '"W. Mellert"'
Autor:
W. Mellert, T. Walk, E. Fabian, H. Kamp, Saskia Sperber, Xiaoqi Jiang, Jana Keller, Michael Manfred Herold, B. van Ravenzwaay, V. Strauss
Publikováno v:
Toxicology Letters. 301:42-52
For regulatory purposes prenatal developmental toxicity (OECD No. 414) studies are routinely performed in our laboratories. The suitability of metabolomics as technology to identify maternal toxicity in such studies was investigated. Plasma was sampl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693175701c7428bb077d5957692eda5f
https://doi.org/10.1016/j.toxlet.2018.10.032
https://doi.org/10.1016/j.toxlet.2018.10.032
Autor:
Volker Strauss, B. van Ravenzwaay, C. Behr, Ivonne M.C.M. Rietjens, H. Kamp, T. Walk, Erik Peter, W. Mellert, G. Krennrich, E. Fabian
Publikováno v:
Archives of Toxicology 91 (2017) 10
Archives of Toxicology, 91(10), 3439-3454
Archives of Toxicology, 91(10), 3439-3454
The intestinal microbiota contributes to the metabolism of its host. Adequate identification of the microbiota’s impact on the host plasma metabolites is lacking. As antibiotics have a profound effect on the microbial composition and hence on the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46807d79e1aa8622af21e7bbb32f8d8c
https://doi.org/10.1007/s00204-017-1949-2
https://doi.org/10.1007/s00204-017-1949-2
Autor:
W. Mellert, H. Kamp, E. Fabian, Frank Faulhammer, Alexander Strigun, O. Lemke, M. Spitzer, Saskia Sperber, T. Walk, Erik Peter, B. van Ravenzwaay, V. Strauss
Publikováno v:
Regulatory Toxicology and Pharmacology. 81:288-304
New technologies, such as metabolomics, can address chemical grouping and read across from a biological perspective. In a virtual case study, we selected MCPP as target substance and MCPA and 2,4-DP as source substances with the goal to waive a 90-da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3e53ee3e4bb0555cea6622b7bb2b48
Autor:
Michael Manfred Herold, H. Kamp, R. Looser, Natalie Bordag, A. Prokudin, W. Mellert, M. Spitzer, V. Strauss, Erik Peter, Lan Ma-Hock, G. Montoya, Rene Zbranek, B. van Ravenzwaay, E. Fabian, G. Krennrich, T. Walk
Publikováno v:
Toxicology Letters. 255:11-23
The MetaMap®-Tox database contains plasma-metabolome and toxicity data of rats obtained from oral administration of 550 reference compounds following a standardized adapted OECD 407 protocol. Here, metabolic profiles for aniline (A), chloroform (CL)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bcf9709de7c079a6783e0e29cf67c05
https://doi.org/10.1016/j.toxlet.2016.05.003
https://doi.org/10.1016/j.toxlet.2016.05.003
Autor:
V. Strauss, H. Kamp, E. Fabian, G. Krennrich, B. van Ravenzwaay, W. Mellert, T. Walk, Erik Peter, Michael Manfred Herold, R. Looser, G. Montoya
Publikováno v:
Toxicology Letters. 227:20-28
The identification of the no observed adverse effect level (NOAEL) is the key regulatory outcome of toxicity studies. With the introduction of “omics” technologies into toxicological research, the question arises as to how sensitive these technol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c156f8ab275cdf36956836ca0ac6d6e7
https://doi.org/10.1016/j.toxlet.2014.03.004
https://doi.org/10.1016/j.toxlet.2014.03.004
Autor:
B. van Ravenzwaay, T. Walk, H. Kamp, V. Strauss, R. Looser, W. Mellert, G. Krennrich, Michael Manfred Herold, E. Leibold, E. Fabian, J. Wiemer, A. Prokoudine
Publikováno v:
Toxicology Letters. 215:143-149
BASF has developed a rat plasma metabolomics database (MetaMap®Tox) containing the metabolome of more than 500 chemicals, agrochemicals and drugs, for which the toxicity is well known, derived from 28-day repeated dose toxicity studies in rats. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ee6fbdfe3250ffb1f9566b2e4e0293
https://doi.org/10.1016/j.toxlet.2012.09.015
https://doi.org/10.1016/j.toxlet.2012.09.015
Autor:
A. Prokoudine, Michael Manfred Herold, V. Strauss, H. Kamp, W. Mellert, Sibylle Groeters, E. Fabian, G. Krennrich, J. Wiemer, T. Walk, B. van Ravenzwaay, W. Mattes, P. Ruiz-Noppinger, R. Looser
Publikováno v:
Bioanalysis. 4:2291-2301
BASF and Metanomics have built-up the database MetaMap®-Tox containing rat plasma metabolome data for more than 500 reference compounds. Phenytoin was administered to five Wistar rats of both sexes at dietary dose levels of 600 and 2400 ppm over 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0632ec2a8d7d467af21a09d7ab37142b
https://doi.org/10.4155/bio.12.214
https://doi.org/10.4155/bio.12.214
Autor:
Michael Manfred Herold, M.D. Kapp, W. Mellert, H. Kamp, T. Walk, B. van Ravenzwaay, G. Krennrich, E. Fabian, J. Wiemer, V. Strauss, A. Prokoudine, R. Looser
Publikováno v:
Toxicology Letters. 207:173-181
Metabolite profiling (metabolomics) elucidates changes in biochemical pathways under various conditions, e.g., different nutrition scenarios or compound administration. BASF and metanomics have obtained plasma metabolic profiles of approximately 500
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd049633e0493ad4f1f5d80076ceb588
https://doi.org/10.1016/j.toxlet.2011.08.013
https://doi.org/10.1016/j.toxlet.2011.08.013
Publikováno v:
Toxicology Letters. 177:156-167
Administration of an iron-deficient diet to Wistar rats resulted within 14 days in reduced serum iron concentrations, a microcytic hypochromic anemia, characteristic for impaired hemoglobin synthesis, and an increase of duodenal epithelial cell proli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5690423722210698d1fc4dde5409c9
https://doi.org/10.1016/j.toxlet.2008.01.012
https://doi.org/10.1016/j.toxlet.2008.01.012
Publikováno v:
Regulatory Toxicology and Pharmacology. 42:24-36
Styrene is not carcinogenic in rats but has caused pneumotoxicity and increased lung tumors after inhalation in mice. This study investigated whether styrene-7,8-oxide, ring-oxidized, and side-chain hydroxylated styrene metabolites induce cell prolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900126bbfafcf7e5eefd29e97fa62983
https://doi.org/10.1016/j.yrtph.2005.01.002
https://doi.org/10.1016/j.yrtph.2005.01.002