Zobrazeno 1 - 10
of 158
pro vyhledávání: '"W. McIntyre Burnham"'
Autor:
Ameer Y. Taha, Marc-Olivier Trepanier, Flaviu A. Coibanu, Anjali Saxena, Melanie A. Jeffrey, Nadeen M. Y. Taha, W. McIntyre Burnham, Richard P. Bazinet
Publikováno v:
Frontiers in Neurology, Vol 9 (2019)
Background: Brain concentrations of omega-3 docosahexaenoic acid (DHA, 22:6n-3) have been reported to positively correlate with seizure thresholds in rodent seizure models. It is not known whether brain DHA depletion, achieved by chronic dietary omeg
Externí odkaz:
https://doaj.org/article/1aa7449ea58e49b796670d2bc51a1da7
Autor:
Peter A. Abdelmalik, Philip Liang, Michael Weisspapir, Marina Samoilova, W. McIntyre Burnham, Peter L. Carlen
Publikováno v:
Neurobiology of Disease, Vol 29, Iss 2, Pp 201-209 (2008)
The brain is heavily dependant on glucose for its function and survival. Hypoglycemia can have severe, irreversible consequences, including seizures, coma and death. However, the in vivo content of brain glycogen, the storage form of glucose, is meag
Externí odkaz:
https://doaj.org/article/9cf9bd634d5748d5b1d2fb21bbecc42c
Autor:
Peter A. Abdelmalik, Patrick Shannon, Adelaide Yiu, Philip Liang, Yana Adamchik, Michael Weisspapir, Marina Samoilova, W. McIntyre Burnham, Peter L. Carlen
Publikováno v:
Neurobiology of Disease, Vol 26, Iss 3, Pp 646-660 (2007)
Severe hypoglycemia constitutes a medical emergency, involving seizures, coma and death. We hypothesized that seizures, during limited substrate availability, aggravate hypoglycemia-induced brain damage. Using immature isolated, intact hippocampi and
Externí odkaz:
https://doaj.org/article/9980caa3581a41cba893fb61e448ff53
Autor:
Amy J. Ramsey, Nirunthan Sivananthan, Matthieu Schapira, W. McIntyre Burnham, Vincent M. Lam, Mostafa H. Abdelrahman, Sean Harrington, David B. Finlay, Ruth A. Ross, Jibran Y. Khokhar, Chun Kit Li, Laurent Trembleau, Iain R. Greig, Ali Salahpour, Kim S. Sugamori, Catharine A. Mielnik, Michelle Glass, Hayley H. A. Thorpe
Publikováno v:
Neuropsychopharmacology
The endocannabinoid system (eCBs) encompasses the endocannabinoids, their synthetic and degradative enzymes, and cannabinoid (CB) receptors. The eCBs mediates inhibition of neurotransmitter release and acts as a major homeostatic system. Many aspects
Publikováno v:
EpilepsiaREFERENCES. 62(9)
OBJECTIVE Focal impaired awareness seizures (FIASs) are the most common seizure type in adults and are often refractory to medication. Management of FIASs is clinically challenging, and new interventions are needed for better seizure control. The amy
Publikováno v:
Epilepsy Research. 148:78-89
Patients with focal temporal lobe seizures often experience transient episodes of impaired awareness with behavioral arrest, but the precise mechanism remains unknown. The Network Inhibition Hypothesis attributes these deficits to a loss of cholinerg
Autor:
W. McIntyre Burnham, Yinhao Violet Wu
Publikováno v:
Seizure. 63:26-36
The anti-seizure effects of progesterone family compounds have long been known. Over the years, however, most studies have focused on progesterone and on its secondary metabolite allopregnanolone (ALLO), with less attention being paid to its primary
Publikováno v:
Clinical Neurophysiology. 132:e6
Background. Depression is the most common psychiatric comorbidity in people living with epilepsy, affecting approximately 25–35% of patients. Antidepressants are typically prescribed for depression, but they only provide relief in about two-thirds
Publikováno v:
Neurological research. 41(7)
Introduction: We have been exploring the effects of dihydroprogesterone in female amygdala-kindled rats. For intraperitoneal (i.p.) time-response studies, we used a vehicle containing the common solvent, benzyl alcohol (BnOH). The vehicle containing
Autor:
Yinhao Violet Wu, W. McIntyre Burnham
Publikováno v:
Epilepsy research. 146
Objective The present study investigated the anti-seizure effects of 5α-dihydroprogesterone (DHP) in an animal model of human drug-resistant focal seizures with impaired awareness. DHP was administered via the intravenous (IV) route. Methods Female