Zobrazeno 1 - 10
of 10
pro vyhledávání: '"W. Martin Rennells"'
Autor:
Catherine M. Beer, W. Martin Rennells, Sergiy G. Krasutsky, Seung H. Lee, Jin-Ming Xiong, Paul Zhichkin
Publikováno v:
Synthesis. 2011:1604-1608
The aromatic amine in fluoroanilines was protected with 2,2,5,5-tetramethyl-1-aza-2,5-disila-cyclopentane (stabase) in order to direct metalation ortho to the fluorine. A series of novel 2-fluoro-3-aminophenylboronates were prepared after quenching t
Autor:
Timothy Rust, Carla Hassler, James P. Harding, Justin J. Richards, Brian I. Bliss, Yuri L. Khmelnitsky, David D. Manning, Marlene L. Cohen, Liaqat Masih, Michael A. Lynch, Jianqing Chen, Kevin L. Christensen, Zhicai Yang, Soshanna Isaacson, Jonathan D. Wierschke, Cathy M. Beer, Russell J. DeOrazio, Jun-Ho Maeng, Lisa H. Peterson, Christopher L. Cioffi, Alexander Usyatinsky, Kevin Fitzpatrick, David J. Fairfax, Matthew Isherwood, Svetlana Dobritsa, W. Martin Rennells
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6538-6541
A new class of 2-substituted benzoxazole carboxamides are presented as potent functional 5-HT(3) receptor antagonists. The chemical series possesses nanomolar in vitro activity against human 5-HT(3)A receptors. A chemistry optimization program was co
Publikováno v:
The Journal of Organic Chemistry. 73:8954-8959
N,N-Dimethylformamidine and novel N,N-diisopropylformamidine protecting groups were used to carry out a one-pot conversion of aminobenzoic acids into the corresponding amides. General conditions for an in situ transformation of aminobenzoic acids and
Autor:
Dana A. Razzano, John F. Quinn, Brian T. Gregg, William G. Earley, W. Martin Rennells, Kathryn C. Golden, Jennifer L. Butcher, Dacia A. Maynard, Dmytro O. Tymoshenko
Publikováno v:
Journal of Combinatorial Chemistry. 9:1036-1040
An efficient and rapid solution phase combinatorial synthesis of a 3-substituted 5-arylidene-1-methyl-2-thiohydantoin library was developed. The salient feature for this library production procedure is the addition of the Lewis acid catalyst, indium(
Autor:
W. Martin Rennells, Dana A. Razzano, Kathryn C. Golden, William G. Earley, Brian T. Gregg, John F. Quinn
Publikováno v:
Synthesis. 2006:4200-4204
A survey of Lewis acids was conducted to facilitate the formation of arylidenethiohydantoins. The use of indium(III) triflate shows significant advantages in facilitating this reaction. In most examples, the Lewis acid promoted catalysis gave shorter
Publikováno v:
Synlett. 2006:0379-0382
A one-pot method for the preparation of 1,8-naphthyridine derivatives is reported. The method involves the dimetalation of an appropriate N-2-pyridylpivalamide or tert-butylcarbamate followed by reaction with a β-dimethylamino or β-alkoxyacrolein d
Autor:
W. Martin Rennells, Seung H. Lee, Sergiy G. Krasutsky, Jin-Ming Xiong, Paul Zhichkin, Catherine M. Beer
Publikováno v:
ChemInform. 42
N,N-Diprotected anilines of type (III) undergo lithiation ortho to the fluorine substituent upon treatment with lithium tetramethylpiperidine.
Publikováno v:
ChemInform. 40
N,N-Dimethylformamidine and novel N,N-diisopropylformamidine protecting groups were used to carry out a one-pot conversion of aminobenzoic acids into the corresponding amides. General conditions for an in situ transformation of aminobenzoic acids and
Publikováno v:
ChemInform. 37
Autor:
Brian T. Gregg, Kathryn C. Golden, John F. Quinn, Dmytro O. Tymoshenko, William G. Earley, Dacia A. Maynard, Dana A. Razzano, W. Martin Rennells, Jennifer Butcher
Publikováno v:
Journal of Combinatorial Chemistry. Sep2007, Vol. 9 Issue 6, p1036-1040. 5p.