Zobrazeno 1 - 10
of 30
pro vyhledávání: '"W. Mark ABBOTT"'
Autor:
Thomas Phelan, Jean Dunne, Niall Conlon, Clíona Ní Cheallaigh, W. Mark Abbott, Raquel Faba-Rodriguez, Fatima Amanat, Florian Krammer, Mark A. Little, Gerry Hughes, Colm Bergin, Colm Kerr, Sudharshana Sundaresan, Aideen Long, William McCormack, Gareth Brady
Publikováno v:
Viruses, Vol 13, Iss 7, p 1371 (2021)
Serological assays have been widely employed during the coronavirus disease 2019 (COVID-19) pandemic to measure antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to track seroconversion in populations. However, cu
Externí odkaz:
https://doaj.org/article/6b2563b71cab4e91980ae4ca887818c7
Autor:
Timo Vögtle, Sumana Sharma, Jun Mori, Zoltan Nagy, Daniela Semeniak, Cyril Scandola, Mitchell J Geer, Christopher W Smith, Jordan Lane, Scott Pollack, Riitta Lassila, Annukka Jouppila, Alastair J Barr, Derek J Ogg, Tina D Howard, Helen J McMiken, Juli Warwicker, Catherine Geh, Rachel Rowlinson, W Mark Abbott, Anita Eckly, Harald Schulze, Gavin J Wright, Alexandra Mazharian, Klaus Fütterer, Sundaresan Rajesh, Michael R Douglas, Yotis A Senis
Publikováno v:
eLife, Vol 8 (2019)
The immunoreceptor tyrosine-based inhibition motif (ITIM)-containing receptor G6b-B is critical for platelet production and activation. Loss of G6b-B results in severe macrothrombocytopenia, myelofibrosis and aberrant platelet function in mice and hu
Externí odkaz:
https://doaj.org/article/c344e049fe504f759f1164a922d96039
Autor:
Fatima Amanat, Gerry Hughes, Florian Krammer, Colm Kerr, Colm Bergin, Gareth Brady, Jean Dunne, Raquel Faba-Rodriguez, Mark A. Little, Aideen Long, W Mark Abbott, Thomas Phelan, Sudharshana Sundaresan, Cliona Ni Cheallaigh, Niall Conlon, William McCormack
Publikováno v:
Viruses
Volume 13
Issue 7
Viruses, Vol 13, Iss 1371, p 1371 (2021)
Volume 13
Issue 7
Viruses, Vol 13, Iss 1371, p 1371 (2021)
Serological assays have been widely employed during the coronavirus disease 2019 (COVID-19) pandemic to measure antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to track seroconversion in populations. However, cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449826a10ba10fe57c29a74ace5f28c0
https://pubmed.ncbi.nlm.nih.gov/34372581
https://pubmed.ncbi.nlm.nih.gov/34372581
SARS-CoV-2 comprehensive receptor profiling: mechanistic insight to drive new therapeutic strategies
Autor:
Jo Soden, Sarah Mv Brockbank, Lucy Coverley, Helen E. Thomas, Jim Freeth, W Mark Abbott, Lyn Rosenbrier Ribeiro, Raquel Faba-Rodriguez, Jenni Delight, Catherine Geh
Here we describe a hypothesis free approach to screen for interactions of SARS-CoV-2 spike (S) protein with human cell surface receptors. We used a library screening approach to detect binding interactions across one of the largest known panels of me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6526ed0c8f0b1a7d9e496dfbfe2eb929
https://doi.org/10.1101/2021.03.11.434937
https://doi.org/10.1101/2021.03.11.434937
Publikováno v:
Biotechnology and Bioengineering. 114:2348-2359
Certain recombinant proteins are deemed "difficult to express" in mammalian expression systems requiring significant cell and/or process engineering to abrogate expression bottlenecks. With increasing demand for the production of recombinant proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cb9543d44bedcf106cb1e0a6fc49a28
https://doi.org/10.1002/bit.26358
https://doi.org/10.1002/bit.26358
Autor:
Rachel Rowlinson, Alastair J. Barr, Scott Pollack, Juli Warwicker, Jordan Lane, Alexandra Mazharian, Riitta Lassila, Klaus Fütterer, Harald Schulze, Annukka Jouppila, Christopher W Smith, Yotis A. Senis, Mitchell J. Geer, Gavin J. Wright, Jun Mori, Helen J McMiken, Derek Ogg, Daniela Semeniak, Zoltan Nagy, Michael R. Douglas, Cyril Scandola, Timo Vögtle, Anita Eckly, Tina Howard, Sundaresan Rajesh, Catherine Geh, W Mark Abbott, Sumana Sharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da6d88bbd9eb7d2bcf4e273f3cb396ce
https://doi.org/10.7554/elife.46840.060
https://doi.org/10.7554/elife.46840.060
Autor:
W Mark Abbott, Gavin J. Wright, Alexandra Mazharian, Cyril Scandola, Daniela Semeniak, Christopher W Smith, Juli Warwicker, Yotis A. Senis, Mitchell J. Geer, Catherine Geh, Sundaresan Rajesh, Derek Ogg, Rachel Rowlinson, Jordan Lane, Klaus Fütterer, Anita Eckly, Annukka Jouppila, Michael R. Douglas, Harald Schulze, Zoltan Nagy, Timo Vögtle, Scott Pollack, Helen J McMiken, Alastair J. Barr, Riitta Lassila, Jun Mori, Sumana Sharma, Tina Howard
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
The immunoreceptor tyrosine-based inhibition motif (ITIM)-containing receptor G6b-B is critical for platelet production and activation, loss of which results in severe macrothrombocytopenia and aberrant platelet function in mice and humans. Using a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b619476bd12bcfa38e3e25257108958
Autor:
Stephen T. Durant, L. David Finger, Mark J. Thompson, Jane A. Grasby, Thomas Ward, J. Willem M. Nissink, W. Mark Abbott, Steven J. Shaw, Catrine Sioberg, Clifford David Jones, Judit E. Debreczeni, Jack C. Exell, Claire McWhirter, Daniel Martinez Molina
Publikováno v:
Nature chemical biology
The structure-specific nuclease human flap endonuclease-1 (hFEN1) plays a key role in DNA replication and repair and may be of interest as an oncology target. We present the crystal structure of inhibitor-bound hFEN1, which shows a cyclic N-hydroxyur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acad248f883063128e76237c1086c207
http://europepmc.org/articles/PMC5348030
http://europepmc.org/articles/PMC5348030
Autor:
Hirra, Hussain, David I, Fisher, Robert G, Roth, W, Mark Abbott, Manuel Alejandro, Carballo-Amador, Jim, Warwicker, Alan J, Dickson
Publikováno v:
Febs Letters
Due in part to the needs of the biopharmaceutical industry, there has been an increased drive to generate high quality recombinant proteins in large amounts. However, achieving high yields can be a challenge as the novelty and increased complexity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37d9d27f4b949c873d9fc2d5236119dd
https://pubmed.ncbi.nlm.nih.gov/29933498
https://pubmed.ncbi.nlm.nih.gov/29933498
Autor:
W. Mark Abbott, Edward A. McKenzie
Publikováno v:
Mckenzie, E & Abbott, WM 2018, ' Expression of recombinant proteins in insect and mammalian cells ', Methods, pp. 40 . https://doi.org/10.1016/j.ymeth.2018.05.013
Purified recombinant proteins are key reagents in academic and industrial research. The ability to make these proteins quickly often relies on the availability of higher eukaryotic cell hosts such as insect and mammalian cells where there is a very w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30acb478e264ac0d2e28f40a116bc26f
https://pubmed.ncbi.nlm.nih.gov/29778647
https://pubmed.ncbi.nlm.nih.gov/29778647