Zobrazeno 1 - 10
of 14
pro vyhledávání: '"W. M. Welch"'
Publikováno v:
Psychopharmacology. 100:470-476
Tritiated sertraline, a radiolabeled form of a potent and selective inhibitor of serotonin uptake, was found to bind with high affinity to rat whole brain membranes. Characterization studies showed that [3H] sertraline binding occurred at a single si
Autor:
W. M. Welch
Publikováno v:
Synthetic Communications. 12:1089-1092
The naturally occurring zwitterionic alkaloid muscimol 3 1 has been of considerable pharmacological interest in recent years, it being the best example of an in vivo active mimetic of the neurotransmitter γ-aminobutyric acid (GABA).2 A number of syn
Publikováno v:
The Journal of Organic Chemistry. 36:157-161
Autor:
W. M. WELCH
Publikováno v:
Chemischer Informationsdienst. 7
Publikováno v:
Chemischer Informationsdienst. 5
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 226(3)
Sertraline [1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine] was found to be a highly selective and potent competitive inhibitor of synaptosomal serotonin uptake. Sertraline also selectively reduced ex vivo uptake of serotoni
Autor:
W. M. WELCH
Publikováno v:
Chemischer Informationsdienst. 13
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 17(5)
Sertaline [1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1- naphthalenamine] is a potent and selective inhibitor of neuronal serotonin uptake and is currently under development for the treatment of depression and of obesity. The drug is gr
Publikováno v:
Molecular pharmacology. 17(1)
Autor:
W. M. WELCH
Publikováno v:
Chemischer Informationsdienst. 9