Výsledky vyhledávání - "W. M. Shannon"

Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases alpha, beta, and gamma by the 5'-triphosphates of carbovir, 3'-azido-3'-deoxythymidine, 2',3'-dideoxyguanosine and 3'-deoxythymidine. A novel RNA template for the evaluation of antiretroviral drugs

Autor: W B Parker, E L White, S C Shaddix, L J Ross, R W Buckheit, J M Germany, J A Secrist, R Vince, W M Shannon

Publikováno v: Journal of Biological Chemistry. 266:1754-1762

Carbovir (the carbocyclic analog of 2'-3'-didehydro-2',3'-dideoxyguanosine) is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) replication. Assays were developed to assess the mechanism of inhibition by the 5'-triphosphate of carbov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9af8f1c6457179ad5f8439b69df23f55
https://doi.org/10.1016/s0021-9258(18)52360-7

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Phosphorylation of the enantiomers of the carbocyclic analog of 2'-deoxyguanosine in cells infected with herpes simplex virus type 1 and in uninfected cells. Lack of enantiomeric selectivity with the viral thymidine kinase

Autor: L L, Bennett, W B, Parker, P W, Allan, L M, Rose, Y F, Shealy, J A, Secrist, J A, Montgomery, G, Arnett, R L, Kirkman, W M, Shannon

Publikováno v: Molecular pharmacology. 44(6)

CdG, the carbocyclic analog of 2'-deoxyguanosine, is active against herpes, hepatitis B, and human cytomegaloviruses. We have studied the interaction of the tritiated enantiomers of CdG with the herpes simplex virus type 1-specific thymidine kinase (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b42ecce0509fc371e75732c37714bb8
https://pubmed.ncbi.nlm.nih.gov/8264563

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Incorporation of the carbocyclic analog of 2'-deoxyguanosine into the DNA of herpes simplex virus and of HEp-2 cells infected with herpes simplex virus

Autor: W B, Parker, S C, Shaddix, P W, Allan, G, Arnett, L M, Rose, W M, Shannon, Y F, Shealy, J A, Montgomery, J A, Secrist, L L, Bennett

Publikováno v: Molecular pharmacology. 41(2)

The carbocyclic analog of 2'-deoxyguanosine (CdG) is active against herpes simplex virus (HSV), human cytomegalovirus, and human hepatitis-B virus. In order to understand the mechanism of action of this compound against HSV, we have evaluated (a) the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a802a400d5467e8274a208ce9d8afad
https://pubmed.ncbi.nlm.nih.gov/1311407

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In vitro evaluation of the synergistic antiviral effects of acemannan in combination with azidothymidine and acyclovir

Autor: J B, Kahlon, M C, Kemp, N, Yawei, R H, Carpenter, W M, Shannon, B H, McAnalley

Publikováno v: Molecular biotherapy. 3(4)

The antiviral effects of selected combinations between acemannan (ACE-M), a long-chained, polydispersed, beta-(1,4)-acetylated mannan, were tested in combination with azidothymidine (AZT) and acyclovir (ACY) in vitro. The rationale for such combinati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ad058abf16cfe46437b2d3ac7973d1a6
https://pubmed.ncbi.nlm.nih.gov/1662957

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Inhibition of AIDS virus replication by acemannan in vitro

Autor: J B, Kahlon, M C, Kemp, R H, Carpenter, B H, McAnalley, H R, McDaniel, W M, Shannon

Publikováno v: Molecular biotherapy. 3(3)

Acemannan (ACE-M), a beta-(1,4)-linked acetylated mannan, was evaluated for in vitro activity against human immunodeficiency virus type 1 (HIV-1). Castanospermine (CAS), deoxymannojirimycin (DMN), swainsonine (SWS), azidothymidine (AZT), and dideoxyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6b7bbdc6b43bf0956416df364cdf3d80
https://pubmed.ncbi.nlm.nih.gov/1768365

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Autor: W B, Parker, E L, White, S C, Shaddix, L J, Ross, R W, Buckheit, J M, Germany, J A, Secrist, R, Vince, W M, Shannon

Publikováno v: The Journal of biological chemistry. 266(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d5d54d6488f675f3198c23b44cdaaf23
https://pubmed.ncbi.nlm.nih.gov/1703154

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Sediment Transport and Deposition in Trickle Irrigation Laterals

Autor: null W. M. Shannon P.E., null L. G. James, null D. L. Bassett, null W. C. Mih

Publikováno v: Transactions of the ASAE. 25:0160-0164

SUSPENDED loads in waters used for trickle irriga-tion contribute to sedimentation in laterals and plug-ging of emitters. The nature of sediment transport and deposition in trickle irrigation systems has not been previously examined. The spatial and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c8122e91284a7aecc35a5b954b5889e
https://doi.org/10.13031/2013.33496

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Synthesis and antiviral evaluation of carbocyclic analogs of ribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines

Autor: Y F, Shealy, J D, Clayton, G, Arnett, W M, Shannon

Publikováno v: Journal of Medicinal Chemistry. 27:670-674

Carbocyclic analogues of ribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8- azapurines were prepared from the 2-amino-6-chloropurine ribofuranoside analogue (2) and the 2-amino-6-chloro-8- azapurine ribofuranoside analog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371d43037e493694b89f75c0a64c4b14
https://doi.org/10.1021/jm00371a020

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Synthesis and antiviral activity of carbocyclic analogs of 2'-deoxyribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines

Autor: Y F, Shealy, C A, O'Dell, W M, Shannon, G, Arnett

Publikováno v: Journal of Medicinal Chemistry. 27:1416-1421

(+/-)-(1 alpha, 2 beta, 4 alpha)-4-[(2,5-Diamino-6-chloro-4-pyrimidinyl) amino]-2-hydroxycyclopentanemethanol (9) was synthesized by beginning with 2-amino-4,6-dichloropyrimidine and (+/-)-1 alpha, 2 beta, 4 alpha)-4-amino-2-hydroxycyclopentanemethan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e654d09a8f3bb7872cc47b6e66219c92
https://doi.org/10.1021/jm00377a007

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