Zobrazeno 1 - 10
of 47
pro vyhledávání: '"W. M. Abraham"'
Autor:
K J, Coote, D, Paisley, S, Czarnecki, M, Tweed, H, Watson, A, Young, R, Sugar, M, Vyas, N J, Smith, U, Baettig, P J, Groot-Kormelink, M, Gosling, R, Lock, B, Ethell, G, Williams, A, Schumacher, J, Harris, W M, Abraham, J, Sabater, C T, Poll, T, Faller, S P, Collingwood, H, Danahay
Publikováno v:
British journal of pharmacology. 172(11)
Inhaled amiloride, a blocker of the epithelial sodium channel (ENaC), enhances mucociliary clearance (MCC) in cystic fibrosis (CF) patients. However, the dose of amiloride is limited by the mechanism-based side effect of hyperkalaemia resulting from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5e0e6b6336c8eae75d7bde05918063e
https://pubmed.ncbi.nlm.nih.gov/25573195
https://pubmed.ncbi.nlm.nih.gov/25573195
Autor:
T. R. Jones, M. Labelle, M. Belley, E. Champion, L. Charette, J. Evans, A. W. Ford-Hutchinson, J. -Y. Gauthier, A. Lord, P. Masson, M. McAuliffe, C. S. McFarlane, K. M. Metters, C. Pickett, H. Piechuta, C. Rochette, I. W. Rodger, N. Sawyer, R. N. Yoyng, R. Zamboni, W. M. Abraham
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 73:191-201
Montelukast sodium (Singulair™), also known as MK-0476 (1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)-(E)-ethenyl)phenyl)(3-2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane) acetic acid sodium salt, is a potent and selective inhibitor of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6921a19999723f662391309297b826b0
https://doi.org/10.1139/y95-028
https://doi.org/10.1139/y95-028
Autor:
D W Howat, John Robert Porter, Neil Gozzard, Martyn Kim Robinson, W M Abraham, Graham John Warrellow, Anthony Shock, Sarah Catherine Archibald, John Clifford Head, Ted A.H. Parton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:997-999
Using disulphide cysteine-based inhibitors as lead structures, this communication describes our strategy for identifying more stable, potent antagonists of the alpha4beta1 integrin. These studies ultimately discovered potent, low molecular weight inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ded68239129cda0bbe1ec2b0bb8fb66
https://doi.org/10.1016/s0960-894x(00)00147-5
https://doi.org/10.1016/s0960-894x(00)00147-5
Publikováno v:
IFMBE Proceedings ISBN: 9783642016967
Severe hemorrhage from traumatic injury is a major causative factor in almost half of these deaths on the battlefield, especially during the early period (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7d43929bc5395a3267caaeaacd7cb2e
https://doi.org/10.1007/978-3-642-01697-4_108
https://doi.org/10.1007/978-3-642-01697-4_108
Autor:
Ko-Chung Lin, Humayun Saleem Ateeq, Castro Alfredo C, Diane R Leone, Hammond Charles E, S Kalkunte, Steve Adams, Lillian T. Chong, S H Hsiung, A G Sprague, W M Abraham, L. L. Chen, Roy R. Lobb, Alan Gill, R B Pepinsky, Wen-Cherng Lee, Zimmerman Craig N
Publikováno v:
Journal of medicinal chemistry. 42(5)
Integrin alpha4beta1 mediates leukocyte recruitment, activation, mediator release, and apoptosis inhibition, and it plays a central role in inflammatory pathophysiology. High-affinity, selective inhibitors of alpha4beta1, based on the Leu-Asp-Val (LD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522e7da338b1fa12444363cd0cce12eb
https://pubmed.ncbi.nlm.nih.gov/10072689
https://pubmed.ncbi.nlm.nih.gov/10072689
Autor:
R R, Lobb, W M, Abraham, L C, Burkly, A, Gill, W, Ma, J A, Knight, D R, Leone, G, Antognetti, R B, Pepinsky
Publikováno v:
Annals of the New York Academy of Sciences. 796
Evidence for a central role for the integrins alpha 4 beta 1 and alpha 4 beta 7 in leukocyte pathophysiology is rapidly accumulating. Five distinct alpha 4 mAbs, each able to block alpha 4-dependent adhesion in vitro, show beneficial effects in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23a43936db6479e6751d7cd278379c78
https://pubmed.ncbi.nlm.nih.gov/8906218
https://pubmed.ncbi.nlm.nih.gov/8906218
Publikováno v:
The European respiratory journal. Supplement. 22
The alpha 4 integrins are heterodimeric leucocyte cell surface molecules central to their cell and matrix adhesive interactions. The integrin alpha 4 beta 1 interacts with the immunoglobulin superfamily member vascular cell adhesion molecule-1 (VCAM-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::745a87151288b29f02bf8840eda1ca62
https://pubmed.ncbi.nlm.nih.gov/8871053
https://pubmed.ncbi.nlm.nih.gov/8871053
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 72(3)
We previously reported that the airway hyperresponsiveness (AHR) that follows antigen challenge is mediated, in part, by the generation of reactive oxygen species. The purpose of this study was to provide quantitative morphologic evidence of oxygen r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d2a9000259005974736451e0141688ed
https://pubmed.ncbi.nlm.nih.gov/7898054
https://pubmed.ncbi.nlm.nih.gov/7898054