Zobrazeno 1 - 10
of 571
pro vyhledávání: '"W. Lund"'
Autor:
Marina T. Broz, Emily Y. Ko, Kristin Ishaya, Jinfen Xiao, Marco De Simone, Xen Ping Hoi, Roberta Piras, Basia Gala, Fernando H. G. Tessaro, Anja Karlstaedt, Sandra Orsulic, Amanda W. Lund, Keith Syson Chan, Jlenia Guarnerio
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract T cell-based immunotherapies have exhibited promising outcomes in tumor control; however, their efficacy is limited in immune-excluded tumors. Cancer-associated fibroblasts (CAFs) play a pivotal role in shaping the tumor microenvironment and
Externí odkaz:
https://doaj.org/article/3c3fee63de4c4625909fa4b34fc910c7
Autor:
Julia Femel, Cameron Hill, Irineu Illa Bochaca, Jamie L. Booth, Tina G. Asnaashari, Maria M. Steele, Ata S. Moshiri, Hyungrok Do, Judy Zhong, Iman Osman, Sancy A. Leachman, Takahiro Tsujikawa, Kevin P. White, Young H. Chang, Amanda W. Lund
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionQuantitative, multiplexed imaging is revealing complex spatial relationships between phenotypically diverse tumor infiltrating leukocyte populations and their prognostic implications. The underlying mechanisms and tissue structures that d
Externí odkaz:
https://doaj.org/article/926e640242f74a12a7b12441e797d677
Autor:
Gregor Werba, Daniel Weissinger, Emily A. Kawaler, Ende Zhao, Despoina Kalfakakou, Surajit Dhara, Lidong Wang, Heather B. Lim, Grace Oh, Xiaohong Jing, Nina Beri, Lauren Khanna, Tamas Gonda, Paul Oberstein, Cristina Hajdu, Cynthia Loomis, Adriana Heguy, Mara H. Sherman, Amanda W. Lund, Theodore H. Welling, Igor Dolgalev, Aristotelis Tsirigos, Diane M. Simeone
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a complex ecosystem that drives tumor progression; however, in-depth single cell characterization of the PDAC TME and its role in response to therapy is lacking.
Externí odkaz:
https://doaj.org/article/3a27bc68fbda40dca2027e7c95c28684
Autor:
Paolo A. Ascierto, Sanjiv S. Agarwala, Christian Blank, Corrado Caracò, Richard D. Carvajal, Marc S. Ernstoff, Soldano Ferrone, Bernard A. Fox, Thomas F. Gajewski, Claus Garbe, Jean-Jacques Grob, Omid Hamid, Michelle Krogsgaard, Roger S. Lo, Amanda W. Lund, Gabriele Madonna, Olivier Michielin, Bart Neyns, Iman Osman, Solange Peters, Poulikos I. Poulikakos, Sergio A. Quezada, Bradley Reinfeld, Laurence Zitvogel, Igor Puzanov, Magdalena Thurin
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-21 (2022)
Abstract Advances in immune checkpoint and combination therapy have led to improvement in overall survival for patients with advanced melanoma. Improved understanding of the tumor, tumor microenvironment and tumor immune-evasion mechanisms has result
Externí odkaz:
https://doaj.org/article/eceaa54ada8b4252a49fcbe967456d2a
Autor:
Gregor Werba, Daniel Weissinger, Emily A. Kawaler, Ende Zhao, Despoina Kalfakakou, Surajit Dhara, Lidong Wang, Heather B. Lim, Grace Oh, Xiaohong Jing, Nina Beri, Lauren Khanna, Tamas Gonda, Paul Oberstein, Cristina Hajdu, Cynthia Loomis, Adriana Heguy, Mara H. Sherman, Amanda W. Lund, Theodore H. Welling, Igor Dolgalev, Aristotelis Tsirigos, Diane M. Simeone
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/fbf64e220d324d00ad2d20768841c89d
Publikováno v:
iScience, Vol 22, Iss , Pp 28-43 (2019)
Lymphatic vessels mediate fluid flows that affect antigen distribution and delivery, lymph node stromal remodeling, and cell-cell interactions, to thus regulate immune activation. Here we review the functional role of lymphatic transport and lymph no
Externí odkaz:
https://doaj.org/article/30300c4056f640c083bd303d3f2835bb
Autor:
Maria M. Steele, Abhinav Jaiswal, Ines Delclaux, Ian D. Dryg, Dhaarini Murugan, Julia Femel, Sunny Son, Haley du Bois, Cameron Hill, Sancy A. Leachman, Young H. Chang, Lisa M. Coussens, Niroshana Anandasabapathy, Amanda W. Lund
Publikováno v:
Nature Immunology. 24:664-675
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d81f0bac00655832508c790267d32d4
https://doi.org/10.1038/s41590-023-01443-y
https://doi.org/10.1038/s41590-023-01443-y
Autor:
Kavita Dhodapkar, Brent A Hanks, Holden T Maecker, Siwen Hu-Lieskovan, Sumati Gupta, Yoshinobu Koguchi, Srabani Bhaumik, Cristina Maccalli, Sylvia Janetzki, Yingdong Zhao, Jean-Charles J B Grivel, Thomas O Kleen, Amanda W Lund, Yolanda D Mahnke, Ruslan D Novosiadly, Senthamil R Selvan, Tasha Sims
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Since the publication of the Society for Immunotherapy of Cancer’s (SITC) original cancer immunotherapy biomarkers resource document, there have been remarkable breakthroughs in cancer immunotherapy, in particular the development and approval of im
Externí odkaz:
https://doaj.org/article/15ac320dfb9843698d79bbf6c3576138
Autor:
Adam C. Soloff, Katherine E. Jones, Amy A. Powers, Pranav Murthy, Yue Wang, Kira L. Russell, Miranda Byrne-Steele, Amanda W. Lund, Jian-Min Yuan, Sara E. Monaco, Jian Han, Rajeev Dhupar, Michael T. Lotze
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Pleural effusions, when benign, are attributed to cardiac events and suffusion of fluid within the pleural space. When malignant, lymphatic obstruction by tumor and failure to absorb constitutively produced fluid is the predominant formulation. The p
Externí odkaz:
https://doaj.org/article/5a91f8982a8f4d58a0286b73dfb64139
Autor:
Christopher P. Loo, Nicholas A. Nelson, Ryan S. Lane, Jamie L. Booth, Sofia C. Loprinzi Hardin, Archana Thomas, Mark K. Slifka, Jeffrey C. Nolz, Amanda W. Lund
Publikováno v:
Cell Reports, Vol 20, Iss 13, Pp 3176-3187 (2017)
Lymphatic vessels lie at the interface between peripheral sites of pathogen entry, adaptive immunity, and the systemic host. Though the paradigm is that their open structure allows for passive flow of infectious particles from peripheral tissues to l
Externí odkaz:
https://doaj.org/article/583a95819dd04ca3bbd3ef5cf647b77c