Zobrazeno 1 - 10
of 66
pro vyhledávání: '"W. Luczak"'
Autor:
Sara Ortega-Atienza, Casey Krawic, Lauren Watts, Caitlin McCarthy, Michal W. Luczak, Anatoly Zhitkovich
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Immunoproteasomes are known for their involvement in antigen presentation. However, their broad tissue presence and other evidence are indicative of nonimmune functions. We examined a role for immunoproteasomes in cellular responses to the e
Externí odkaz:
https://doaj.org/article/19f101b59bc04e38be53c554606594ca
Publikováno v:
Cell Cycle. 20:1812-1827
The hypoxia-induced transcription factor HIF1 inhibits cell growth in normoxia through poorly understood mechanisms. A constitutive upregulation of hypoxia response is associated with increased malignancy, indicating a loss of antiproliferative effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::029c0f9089021290bb870a3e6dd5250d
https://doi.org/10.1080/15384101.2021.1959988
https://doi.org/10.1080/15384101.2021.1959988
Autor:
Michał W Luczak, Paweł P Jagodziński
Publikováno v:
Folia Histochemica et Cytobiologica, Vol 44, Iss 3, Pp 143-154 (2006)
Epigenetic modifications include DNA methylation and covalent modification of histones. These alterations are reversible but very stable and exert a significant impact on the regulation of gene expression. Changes in methylation of promoter or first
Externí odkaz:
https://doaj.org/article/2c082af2e79b4596885687ddb5b6dd23
Publikováno v:
Cell Cycle
The hypoxia-induced transcription factor HIF1 inhibits cell growth in normoxia through poorly understood mechanisms. A constitutive upregulation of hypoxia response is associated with increased malignancy, indicating a loss of antiproliferative effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bcbe38a99e0cd98cec54318306a9b10f
https://pubmed.ncbi.nlm.nih.gov/34382917
https://pubmed.ncbi.nlm.nih.gov/34382917
Publikováno v:
Toxicol Sci
Cellular reduction of carcinogenic chromium(VI) causes several forms of Cr-DNA damage with different genotoxic properties. Chromate-treated cultured cells have shown a strong proapoptotic activity of the DNA damage-sensitive transcription factor p53.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74bdb6d536931b79bda63e8c189be575
https://doi.org/10.1093/toxsci/kfz178
https://doi.org/10.1093/toxsci/kfz178
Publikováno v:
Free Radic Biol Med
Bleomycin is a redox-active drug with anticancer and other clinical applications. It is also frequently used as a tool in fundamental research on cellular responses to DNA double-strand breaks (DSBs). A conversion of bleomycin into its DNA-breaking f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2749b430279866f7b2799e8137458ce3
https://doi.org/10.1016/j.freeradbiomed.2019.03.026
https://doi.org/10.1016/j.freeradbiomed.2019.03.026
Publikováno v:
Seed Regeneration In Cross-Pollinated Species
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::041ed6813d4e796ff456bb8b3a3f675f
https://doi.org/10.1201/9781003079040-20
https://doi.org/10.1201/9781003079040-20
Akademický článek
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Autor:
Michal W. Luczak, Anatoly Zhitkovich
Publikováno v:
Toxicology and Applied Pharmacology. 331:94-100
Nickel is a human carcinogen that acts as a hypoxia mimic by activating the transcription factor HIF-1α and hypoxia-like transcriptomic responses. Hypoxia and elevated HIF-1α are typically associated with drug resistance in cancer cells, which is c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88859ee430f237790e17df769c0fb74
https://doi.org/10.1016/j.taap.2017.05.029
https://doi.org/10.1016/j.taap.2017.05.029
Publikováno v:
Chemical Research in Toxicology
Inhalation of soluble chromium(VI) is firmly linked with higher risks of lung cancer in humans. However, comparative studies in rats have found a high lung tumorigenicity for moderately soluble chromates but no tumors for highly soluble chromates. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb986a460ebd8182bf5b862baaa1c24
https://doi.org/10.1021/acs.chemrestox.7b00172
https://doi.org/10.1021/acs.chemrestox.7b00172