Zobrazeno 1 - 10 of 1 153 pro vyhledávání: '"W. Leitz"'
1
Akademický článek
Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice
Autor: Julia Duerr, Dominik H. W. Leitz, Magdalena Szczygiel, Dmytro Dvornikov, Simon G. Fraumann, Clemens Kreutz, Piotr K. Zadora, Ayça Seyhan Agircan, Philip Konietzke, Theresa A. Engelmann, Jan Hegermann, Surafel Mulugeta, Hiroshi Kawabe, Lars Knudsen, Matthias Ochs, Daniela Rotin, Thomas Muley, Michael Kreuter, Felix J. F. Herth, Mark O. Wielpütz, Michael F. Beers, Ursula Klingmüller, Marcus A. Mall
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Idiopathic pulmonary fibrosis (IPF) is a devastating disease with poor prognosis. Here, the authors show that deficiency of the E3 ubiqutin-protein ligase Nedd4-2 in airway epithelial cells causes IPF-like disease in adult mice. This model may aid st
Externí odkaz: https://doaj.org/article/ae55c88d44b14c0496555b2c7a52b8da
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2
Akademický článek
Linking Fibrotic Remodeling and Ultrastructural Alterations of Alveolar Epithelial Cells after Deletion of Nedd4-2
Autor: Theresa A. Engelmann, Lars Knudsen, Dominik H. W. Leitz, Julia Duerr, Michael F. Beers, Marcus A. Mall, Matthias Ochs
Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 14, p 7607 (2021)
Our previous study showed that in adult mice, conditional Nedd4-2-deficiency in club and alveolar epithelial type II (AE2) cells results in impaired mucociliary clearance, accumulation of Muc5b and progressive, terminal pulmonary fibrosis within 16 w
Externí odkaz: https://doaj.org/article/fbdf45b037d643b88ef5ad8c21754139
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3
Akademický článek
Congenital Deletion of Nedd4-2 in Lung Epithelial Cells Causes Progressive Alveolitis and Pulmonary Fibrosis in Neonatal Mice
Autor: Dominik H. W. Leitz, Julia Duerr, Surafel Mulugeta, Ayça Seyhan Agircan, Stefan Zimmermann, Hiroshi Kawabe, Alexander H. Dalpke, Michael F. Beers, Marcus A. Mall
Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 11, p 6146 (2021)
Recent studies found that expression of NEDD4-2 is reduced in lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and that the conditional deletion of Nedd4-2 in lung epithelial cells causes IPF-like disease in adult mice via multiple
Externí odkaz: https://doaj.org/article/3c6b0915d4e245e79120f1761299b0e9
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4
X-ray speed reading: enabling fast, low noise readout for next-generation CCDs
Autor: Sven C. Herrmann, Peter Orel, Tanmoy Chattopadhyay, Glenn Morris, Gregory Prigozhin, Kevan Donlon, Richard Foster, Marshall W. Bautz, Steve W. Allen, Christopher W. Leitz
Publikováno v: X-Ray, Optical, and Infrared Detectors for Astronomy X.
Current, state-of-the-art CCDs are close to being able to deliver all key performance figures for future strategic X-ray missions except for the required frame rates. Our Stanford group is seeking to close this technology gap through a multi-pronged
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f226279d4b97b66213c4af9e2d446f
https://doi.org/10.1117/12.2630195
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8
Linking Fibrotic Remodeling and Ultrastructural Alterations of Alveolar Epithelial Cells after Deletion of Nedd4-2
Autor: Dominik H. W. Leitz, Michael F. Beers, Lars Knudsen, Julia Duerr, Theresa A. Engelmann, Marcus A. Mall, Matthias Ochs
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 14
International Journal of Molecular Sciences, Vol 22, Iss 7607, p 7607 (2021)
Our previous study showed that in adult mice, conditional Nedd4-2-deficiency in club and alveolar epithelial type II (AE2) cells results in impaired mucociliary clearance, accumulation of Muc5b and progressive, terminal pulmonary fibrosis within 16 w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f7507861a9fef7b77b83506ad48770
http://europepmc.org/articles/PMC8306112
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9
Congenital Deletion of Nedd4-2 in Lung Epithelial Cells Causes Progressive Alveolitis and Pulmonary Fibrosis in Neonatal Mice
Autor: Ayça Seyhan Agircan, Alexander H. Dalpke, Julia Duerr, Marcus A. Mall, Michael F. Beers, Surafel Mulugeta, Hiroshi Kawabe, Stefan Zimmermann, Dominik H. W. Leitz
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences, Vol 22, Iss 6146, p 6146 (2021)
Recent studies found that expression of NEDD4-2 is reduced in lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and that the conditional deletion of Nedd4-2 in lung epithelial cells causes IPF-like disease in adult mice via multiple
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74bf665df952c09b1aff8ab4bc96dbee
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10
Progress toward fast, low-noise, low-power CCDs for Lynx and other high-energy astrophysics missions
Autor: Eric J. Miller, R. G. Morris, Tanmoy Chattopadhyay, Barry E. Burke, Christopher W. Leitz, Andrew Malonis, Michael Cooper, R. Foster, Gregory Y. Prigozhin, Catherine E. Grant, Marshall W. Bautz, Steven W. Allen, Beverly LaMarr, David Craig, C. Thayer, Sven Herrmann, Kevan Donlon
Publikováno v: Space Telescopes and Instrumentation 2020: Ultraviolet to Gamma Ray.
Several high-throughput, high-resolution X-ray mission concepts now under study, including Lynx, a flagship, and AXIS, a probe, require large-format imaging detectors with performance at least as good as the best current generation devices but with m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdb4d2e071ed2bf59e6fc90410f2c517
https://doi.org/10.1117/12.2561441
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