Zobrazeno 1 - 10
of 219
pro vyhledávání: '"W. Lee Kraus"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Signal-induced transcriptional programs regulate critical biological processes through the precise spatiotemporal activation of Immediate Early Genes (IEGs); however, the mechanisms of transcription induction remain poorly understood. By com
Externí odkaz:
https://doaj.org/article/22e84590686e4d8195411cc57f4fc209
Publikováno v:
Gynecologic Oncology Reports, Vol 48, Iss , Pp S13- (2023)
Objectives: PARP proteins are regulators of DNA damage repair in the cell. PARP inhibitors (PARPi) are a class of drugs used to treat ovarian cancer especially in patients with BRCA 1/2 gene mutations and homologous recombination deficiencies. These
Externí odkaz:
https://doaj.org/article/af268d809c5041b996de63df4a0036a0
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
STAT1a is required for pro-inflammatory responses in macrophages. Here the authors reveal that post-translational modification of STAT1a, ADPribosylation, plays a critical role in enhancer formation and activation, thus modulating IFNγ-stimulated in
Externí odkaz:
https://doaj.org/article/e323c3b056fa45c286ff54b1c4102557
Autor:
Tim Y. Hou, W. Lee Kraus
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110944- (2022)
Summary: To better understand the functions of non-coding enhancer RNAs (eRNAs), we annotated the estrogen-regulated eRNA transcriptome in estrogen receptor α (ERα)-positive breast cancer cells using PRO-cap and RNA sequencing. We then cloned a sub
Externí odkaz:
https://doaj.org/article/8c7b07cee3914643bd29fe3eeaf745e2
Autor:
Yuanxin Xi, Jiejun Shi, Wenqian Li, Kaori Tanaka, Kendra L. Allton, Dana Richardson, Jing Li, Hector L. Franco, Anusha Nagari, Venkat S. Malladi, Luis Della Coletta, Melissa S. Simper, Khandan Keyomarsi, Jianjun Shen, Mark T. Bedford, Xiaobing Shi, Michelle C. Barton, W. Lee Kraus, Wei Li, Sharon Y. R. Dent
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background Epigenetic regulators are frequently mutated or aberrantly expressed in a variety of cancers, leading to altered transcription states that result in changes in cell identity, behavior, and response to therapy. Results To define al
Externí odkaz:
https://doaj.org/article/b6b28abd82404ab384f6ee9983f4d6f1
Publikováno v:
Cells, Vol 10, Iss 2, p 313 (2021)
Mono(ADP-ribosyl)ation (MARylation) is a regulatory post-translational modification of proteins that controls their functions through a variety of mechanisms. MARylation is catalyzed by mono(ADP-ribosyl) transferase (MART) enzymes, a subclass of the
Externí odkaz:
https://doaj.org/article/1a578a17d3f54854af13768bcc9a1309
Autor:
Dae-Seok Kim, Cristel V. Camacho, Rohit Setlem, Kangsan Kim, Srinivas Malladi, Tim Y. Hou, Tulip Nandu, Shrikanth S. Gadad, W. Lee Kraus
Publikováno v:
Mol Cancer Res
Long noncoding RNAs have been implicated in many of the hallmarks of cancer. Herein, we found that the expression of lncRNA152 (lnc152; a.k.a. DRAIC), which we annotated previously, is highly upregulated in luminal breast cancer (LBC) and downregulat
The bromodomain family member proteins (BRD; BET proteins) are key coregulators for estrogen receptor alpha (ERα)-mediated transcriptional enhancers. The use of BRD-selective inhibitors has gained much attention as a potential treatment for various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aff07d9f58931fc8c0d16d0e271bba8f
https://doi.org/10.1158/1541-7786.c.6540282.v1
https://doi.org/10.1158/1541-7786.c.6540282.v1
Figure S1. The activity of BET family members is required for the growth of T-47D cells. Figure S2. BET proteins are required for E2-dependent gene expression in T-47D cells. Figure S3. JQ1 does not affect the expression of ERα, SRC2, and SRC3 in MC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b247eb964569f4aabe8100ddd7bb617e
https://doi.org/10.1158/1541-7786.22512585.v1
https://doi.org/10.1158/1541-7786.22512585.v1
Autor:
W. Lee Kraus, Shrikanth S. Gadad, Tulip Nandu, Tim Y. Hou, Srinivas Malladi, Kangsan Kim, Rohit Setlem, Cristel V. Camacho, Dae-Seok Kim
Supplementary Table from Functional Characterization of lncRNA152 as an Angiogenesis-Inhibiting Tumor Suppressor in Triple-Negative Breast Cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50db936c1d2162c2a9e088d59f9f0204
https://doi.org/10.1158/1541-7786.22527989
https://doi.org/10.1158/1541-7786.22527989