Zobrazeno 1 - 10
of 314
pro vyhledávání: '"W. Lee Kraus"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Signal-induced transcriptional programs regulate critical biological processes through the precise spatiotemporal activation of Immediate Early Genes (IEGs); however, the mechanisms of transcription induction remain poorly understood. By com
Externí odkaz:
https://doaj.org/article/22e84590686e4d8195411cc57f4fc209
Publikováno v:
Gynecologic Oncology Reports, Vol 48, Iss , Pp S13- (2023)
Objectives: PARP proteins are regulators of DNA damage repair in the cell. PARP inhibitors (PARPi) are a class of drugs used to treat ovarian cancer especially in patients with BRCA 1/2 gene mutations and homologous recombination deficiencies. These
Externí odkaz:
https://doaj.org/article/af268d809c5041b996de63df4a0036a0
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
STAT1a is required for pro-inflammatory responses in macrophages. Here the authors reveal that post-translational modification of STAT1a, ADPribosylation, plays a critical role in enhancer formation and activation, thus modulating IFNγ-stimulated in
Externí odkaz:
https://doaj.org/article/e323c3b056fa45c286ff54b1c4102557
Autor:
Tim Y. Hou, W. Lee Kraus
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110944- (2022)
Summary: To better understand the functions of non-coding enhancer RNAs (eRNAs), we annotated the estrogen-regulated eRNA transcriptome in estrogen receptor α (ERα)-positive breast cancer cells using PRO-cap and RNA sequencing. We then cloned a sub
Externí odkaz:
https://doaj.org/article/8c7b07cee3914643bd29fe3eeaf745e2
Autor:
Sridevi Challa, Keun W Ryu, Amy L Whitaker, Jonathan C Abshier, Cristel V Camacho, W Lee Kraus
Publikováno v:
eLife, Vol 11 (2022)
ADP-ribosylation (ADPRylation) is a reversible post-translation modification resulting in the covalent attachment of ADP-ribose (ADPR) moieties on substrate proteins. Naturally occurring protein motifs and domains, including WWEs, PBZs, and macrodoma
Externí odkaz:
https://doaj.org/article/effbf367334d444b8ea456af01b78316
Autor:
Lavanya H Palavalli Parsons, Sridevi Challa, Bryan A Gibson, Tulip Nandu, MiKayla S Stokes, Dan Huang, Jayanthi S Lea, W Lee Kraus
Publikováno v:
eLife, Vol 10 (2021)
PARP-7 (TiPARP) is a mono(ADP-ribosyl) transferase whose protein substrates and biological activities are poorly understood. We observed that PARP7 mRNA levels are lower in ovarian cancer patient samples compared to non-cancerous tissue, but PARP-7 p
Externí odkaz:
https://doaj.org/article/a58e7e7a531844d7baa4e600daedecdb
Publikováno v:
Bioinformatics and Biology Insights, Vol 14 (2020)
The differentiation of embryonic stem cells into various lineages is highly dependent on the chromatin state of the genome and patterns of gene expression. To identify lineage-specific enhancers driving the differentiation of progenitors into pancrea
Externí odkaz:
https://doaj.org/article/444c3124aaa8449eaee9484a05144c3a
Autor:
Yuanxin Xi, Jiejun Shi, Wenqian Li, Kaori Tanaka, Kendra L. Allton, Dana Richardson, Jing Li, Hector L. Franco, Anusha Nagari, Venkat S. Malladi, Luis Della Coletta, Melissa S. Simper, Khandan Keyomarsi, Jianjun Shen, Mark T. Bedford, Xiaobing Shi, Michelle C. Barton, W. Lee Kraus, Wei Li, Sharon Y. R. Dent
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background Epigenetic regulators are frequently mutated or aberrantly expressed in a variety of cancers, leading to altered transcription states that result in changes in cell identity, behavior, and response to therapy. Results To define al
Externí odkaz:
https://doaj.org/article/b6b28abd82404ab384f6ee9983f4d6f1
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Dae-Seok Kim, Cristel V. Camacho, Rohit Setlem, Kangsan Kim, Srinivas Malladi, Tim Y. Hou, Tulip Nandu, Shrikanth S. Gadad, W. Lee Kraus
Publikováno v:
Mol Cancer Res
Long noncoding RNAs have been implicated in many of the hallmarks of cancer. Herein, we found that the expression of lncRNA152 (lnc152; a.k.a. DRAIC), which we annotated previously, is highly upregulated in luminal breast cancer (LBC) and downregulat