Extracorporeal life support without systemic anticoagulation: a nitric oxide-based non-thrombogenic circuit for the artificial placenta in an ovine model

Autor: Brian P. Fallon, Orsolya Lautner-Csorba, Terry C. Major, Gergely Lautner, Stephen L. Harvey, Mark W. Langley, Matthew D. Johnson, Claudia Saveski, Niki Matusko, Raja Rabah, Alvaro Rojas-Pena, Mark E. Meyerhoff, Robert H. Bartlett, George B. Mychaliska

Publikováno v: Pediatric Research.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6c7848953c209130286bad42c82b59a
https://doi.org/10.1038/s41390-023-02605-2

Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Autor: Jürgen Brem, Tharindi Panduwawala, Jon Ulf Hansen, Joanne Hewitt, Edgars Liepins, Pawel Donets, Laura Espina, Alistair J. M. Farley, Kirill Shubin, Gonzalo Gomez Campillos, Paula Kiuru, Shifali Shishodia, Daniel Krahn, Robert K. Leśniak, Juliane Schmidt, Karina Calvopiña, María-Carmen Turrientes, Madeline E. Kavanagh, Dmitrijs Lubriks, Philip Hinchliffe, Gareth W. Langley, Ali F. Aboklaish, Anders Eneroth, Maria Backlund, Andrei G. Baran, Elisabet I. Nielsen, Michael Speake, Janis Kuka, John Robinson, Solveiga Grinberga, Lindsay Robinson, Michael A. McDonough, Anna M. Rydzik, Thomas M. Leissing, Juan Carlos Jimenez-Castellanos, Matthew B. Avison, Solange Da Silva Pinto, Andrew D. Pannifer, Marina Martjuga, Emma Widlake, Martins Priede, Iva Hopkins Navratilova, Marek Gniadkowski, Anna Karin Belfrage, Peter Brandt, Jari Yli-Kauhaluoma, Eric Bacque, Malcolm G. P. Page, Fredrik Björkling, Jonathan M. Tyrrell, James Spencer, Pauline A. Lang, Pawel Baranczewski, Rafael Cantón, Stuart P. McElroy, Philip S. Jones, Fernando Baquero, Edgars Suna, Angus Morrison, Timothy R. Walsh, Christopher J. Schofield

Publikováno v: Brem, J, Panduwawala, T, Hansen, J U, Hewitt, J, Liepins, E, Donets, P, Espina, L, Farley, A J M, Shubin, K, Campillos, G G, Kiuru, P, Shishodia, S, Krahn, D, Leśniak, R K, Schmidt Adrian, J, Calvopiña, K, Turrientes, M-C, Kavanagh, M E, Lubriks, D, Hinchliffe, P, Langley, G W, Aboklaish, A F, Eneroth, A, Backlund, M, Baran, A G, Nielsen, E I, Speake, M, Kuka, J, Robinson, J, Grinberga, S, Robinson, L, McDonough, M A, Rydzik, A M, Leissing, T M, Jimenez-Castellanos, J C, Avison, M B, Da Silva Pinto, S, Pannifer, A D, Martjuga, M, Widlake, E, Priede, M, Hopkins Navratilova, I, Gniadkowski, M, Belfrage, A K, Brandt, P, Yli-Kauhaluoma, J, Bacque, E, Page, M G P, Björkling, F, Tyrrell, J M, Spencer, J, Lang, P A, Baranczewski, P, Cantón, R, McElroy, S P, Jones, P S, Baquero, F, Suna, E, Morrison, A, Walsh, T R & Schofield, C J 2022, ' Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors ', Nature Chemistry, vol. 14, pp. 15-24 . https://doi.org/10.1038/s41557-021-00831-x

Carbapenems are vital antibiotics, but their efficacy is increasingly compromised by metallo-beta-lactamases (MBLs). Here we report the discovery and optimization of potent broad-spectrum MBL inhibitors. A high-throughput screen for NDM-1 inhibitors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4fafe7a19ff7ed314c37086b73a558
https://research-information.bris.ac.uk/ws/files/323318874/IC_MBLinh_NatChem_accepted.pdf

A pumpless artificial lung without systemic anticoagulation: The Nitric Oxide Surface Anticoagulation system

Autor: Brian P. Fallon, Adrianna Kayden, Alvaro Rojas Pena, Robert H. Bartlett, Alex J. Thompson, Gergely Lautner, Mark W. Langley, Ronald B. Hirschl, Orsolya Lautner-Csorba, Matthew D. Johnson, Stephen L Harvey

Publikováno v: J Pediatr Surg

Background Artificial lungs have the potential to serve as a bridge to transplantation or recovery for children with end-stage lung disease dependent on extracorporeal life support, but such devices currently require systemic anticoagulation. We desc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc299fc49da548efca8019714f053a4
https://pubmed.ncbi.nlm.nih.gov/34649727

Twenty-four-hour normothermic perfusion of isolated ex vivo hearts using plasma exchange

Autor: Mark J. Hoenerhoff, Robert H. Bartlett, Bailey Schneider, Jonathan W. Haft, Gabe E. Owens, McKenzie Hayes, Alvaro Rojas-Pena, Lise Tchouta, Shelby Reno, Mark W. Langley, Daniel Drake

Publikováno v: The Journal of thoracic and cardiovascular surgery. 164(1)

Cross-circulation of plasma from a paracorporeal animal allows successful ex vivo heart perfusion (EVHP) for 3 days. Little is known about the feasibility of prolonged EVHP without a paracorporeal animal. These experiments evaluated plasma exchange (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2d57715cf52600cd644f5cfd59ac08
https://pubmed.ncbi.nlm.nih.gov/33461814

Nitric Oxide Attenuates the Inflammatory Effects of Air During Extracorporeal Circulation

Autor: Clinton J Poling, Jonathan W. Haft, Mark M Meyerhoff, Alvaro Rojas-Pena, Ben Jamin D Carr, Mark W. Langley, Mark M.P. Jeakle, Orsolya Lautner-Csorba, John M. Toomasian, Robert H. Bartlett, Gergely Lautner

Publikováno v: ASAIO J

Cardiopulmonary bypass (CPB) causes a systemic inflammatory response reaction that may contribute to post-operative complications. One cause relates to the air/blood interface from the extracorporeal circuit. The modulatory effects of blending nitric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dfc97290e24556f69c7898af535e5de
https://pubmed.ncbi.nlm.nih.gov/31425266