Zobrazeno 1 - 10 of 29 pro vyhledávání: '"W. L. Matier"'
1
Esprolol hydrochloride: a new beta adrenergic antagonist with a rapid onset of effect
Autor: W L, Matier, G, Patil
Publikováno v: Heart disease (Hagerstown, Md.). 2(2)
Esprolol is a new, potent, beta adrenergic receptor antagonist that is differentiated from available drugs of this class by its rapid onset, short time to peak effect, and relatively short duration of action after sublingual and oral administration.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a20ff795d50064596a32b209c968e66
https://pubmed.ncbi.nlm.nih.gov/11728252
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2
Synthesis and antiarrhythmic and parasympatholytic properties of substituted phenols. 3. Modifications to the linkage region (region 3)
Autor: W. L. Matier, Cynthia Barcelon-Yang, David M. Stout, Barry S. Brown, Robert D. Reynolds
Publikováno v: Journal of Medicinal Chemistry. 28:295-298
As part of a continuing program of systematically modifying the structure of the class I antiarrhythmic drug changrolin, we synthesized 15 analogues in which the linkage between the two aromatic regions was altered. High antiarrhythmic activity and l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fad73c1ee6f6dddf0d93040c93e5158
https://doi.org/10.1021/jm00381a006
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3
In vitro and in vivo evaluation of two ultrashort-acting beta-adrenoreceptor antagonists: ACC-9129 and ACC-9369
Autor: W. L. Matier, A. Vuong, J. E. Shaffer, R. J. Gorczynski
Publikováno v: Drug Development Research. 7:221-232
ACC-9129 and ACC-9369 were evaluated in guinea pig isolated atria and trachea and in anesthetized dogs and conscious rabbits for beta-blocking potency, duration of action, and intraocular pressure effects. ACC-9129 showed competitive cardioselective
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f5c26e4b330ca419afbe1d7f5a2d796
https://doi.org/10.1002/ddr.430070304
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5
Proximity effects in diaryl derivatives. Part IV. Base-catalysed reactions of 2,2′-di(hydroxyamino)diaryl sulphones and of 2-(hydroxyamino)aryl phenyl sulphones
Autor: W. L. Matier, B. T. Johnston, M. F. Grundon
Publikováno v: J. Chem. Soc. B. :260-266
Reaction of 2,2′-di(hydroxyamino)diaryl sulphones with sodium hydroxide in aqueous dioxan at 20° yields dibenzo [b,f][1,4,5]thiadiazepine 5,11,11-trioxides (X), phenazine 5-oxides (XIV), and phenazine 5,10-dioxides (XV). The formation of the phena
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53f4411b44d381462e70bdd0c79467bc
https://doi.org/10.1039/j29660000260
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7
Proximity effects in diaryl derivatives. Part VI. Base-catalysed rearrangement of 2-(hydroxyamino)aryl aryl sulphones to 2-hydroxy-2′-(arylsulphonyl)azoxybenzenes
Autor: M. F. Grundon, W. L. Matier, D. J. Maitland
Publikováno v: J. Chem. Soc. C. :654-661
Treatment of 2-(hydroxyamino)aryl phenyl sulphones or bis-(2-hydroxyaminoaryl) sulphones with aqueous sodium hydroxide at 20° gives 2-hydroxy-2′-(arylsulphonyl)azoxybenzenes (V) and (VII) and arenesulphonate anions. The hydroxy-group in the azoxy-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6da4773922272ae1bc5b4c073f7f033e
https://doi.org/10.1039/j39710000654
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8
Pharmacology of ACC-9653 (phenytoin prodrug)
Autor: R D Smith, W. L. Matier, B S Brown, R W Maher
Publikováno v: Epilepsia. 30
ACC-9653, the disodium phosphate ester of 3-hydroxymethyl-5,5-diphenylhydantoin, is a prodrug of phenytoin with advantageous physicochemical properties. ACC-9653 is rapidly converted enzymatically to phenytoin in vivo. ACC-9653 and phenytoin sodium h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b408c4fb519467b91983f7abdccd605
https://pubmed.ncbi.nlm.nih.gov/2767010
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