Výsledky vyhledávání

Peptide Hydrophobicity Controls the Activity and Selectivity of Magainin 2 Amide in Interaction with Membranes

Autor: D L MacDonald, W L Maloy, Eberhard Krause, Torsten Wieprecht, Michael Beyermann, Margitta Dathe, Bienert M

Publikováno v: Biochemistry. 36:6124-6132

The magainins are antibacterial peptides from the skin of Xenopus laevis. They show a broad range of activity against prokaryotic cells but lyse eukaryotic cells poorly. To elucidate the influence of peptide hydrophobicity on membrane activity and se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e94239dc8fa0f53b5e7de5f3478035
https://doi.org/10.1021/bi9619987

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Secondary Structure and Location of a Magainin Analogue in Synthetic Phospholipid Bilayers

Autor: Jacob Schaefer, Donald J. Hirsh, Janet L. Hammer, Jack Blazyk, W L Maloy

Publikováno v: Biochemistry. 35:12733-12741

Magainins are cationic, membrane-active peptides which show broad-spectrum antimicrobial activity. We have investigated the secondary structure and location of an analogue of magainin 2 in synthetic phospholipid bilayers using a combination of Fourie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5713ecfc281a76096ddb89b05d572d
https://doi.org/10.1021/bi961468a

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Experimental local therapy of human melanoma with lytic magainin peptides

Autor: W L Maloy, L S Jacob, Meenhard Herlyn, M L Myrga, P W Soballe

Publikováno v: International Journal of Cancer. 60:280-284

Magainin peptides and model amphipathic peptides exhibit antibiotic activity and are also cytolytic for transformed human cells. Here we demonstrate in vitro that MSI-511 (an all-D amino-acid model magainin peptide) and MSI-130 (a margainin analogue)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1750719031fa27db9acb2197bcd84daa
https://doi.org/10.1002/ijc.2910600225

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Structure-activity studies on magainins and other host defense peptides

Autor: W L Maloy, U P Kari

Publikováno v: Biopolymers. 37:105-122

Host defense peptides are widely distributed in nature, being found in species from bacteria to humans. The structures of these peptides from insects, horseshoe crabs, frogs, and mammals are known to have the common features of a net cationic charge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87cb0e1a907f3af1403b114027dbd64b
https://doi.org/10.1002/bip.360370206

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Akademický článek

SYNTHESIS, CHARACTERIZATION, AND ANTIMICROBIAL APPLICATION OF SILVER-INCORPORATED SUPER ABSORBENT GELATIN-BASED NANOGELS.

Autor: Ram, Deepak¹, Dharela, Rohini¹ rohinidharela@gmail.com, Raj, Tilak¹, Kumari, Sangeeta², Chauhan, Ghanshyam S.³

Publikováno v: Rasayan Journal of Chemistry. Jul-Sep2024, Vol. 17 Issue 3, p1163-1173. 11p.

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Defective intracellular transport as a common mechanism limiting expression of inappropriately paired class II major histocompatibility complex alpha/beta chains

Autor: L R Hendrix, John E. Coligan, Ronald N. Germain, Andrea J. Sant, W L Maloy

Publikováno v: The Journal of Experimental Medicine

Distinct combinations of class II major histocompatibility complex (MHC) alpha and beta chains show widely varying efficiencies of cell surface expression in transfected cells. Previous studies have analyzed the regions of the class II chains that ar

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https://doi.org/10.1084/jem.174.4.799

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Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA

Autor: Howard Eck, Gill Diamond, Charles L. Bevins, Michael Zasloff, Michael Brasseur, W. L. Maloy

Publikováno v: Proceedings of the National Academy of Sciences. 88:3952-3956

Extracts of the bovine tracheal mucosa have an abundant peptide with potent antimicrobial activity. The 38-amino acid peptide, which we have named tracheal antimicrobial peptide (TAP), was isolated by a sequential use of size-exclusion, ion-exchange,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1e9b8190451df5d148d6fc70cf1a25
https://doi.org/10.1073/pnas.88.9.3952

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Dissection of H-2Db-restricted cytotoxic T-lymphocyte epitopes on simian virus 40 T antigen by the use of synthetic peptides and H-2Dbm mutants

Autor: Barbara B. Knowles, M Lewis, W L Maloy, Rob Anderson, Yuetsu Tanaka, Janice Milici, Satvir S. Tevethia

Publikováno v: Scopus-Elsevier

Five distinct cytotoxic T-lymphocyte (CTL) recognition sites were identified in the simian virus 40 (SV40) T antigen by using H-2b cells that express the truncated T antigen or antigens carrying internal deletions of various sizes. Four of the CTL re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9afd1d13fd63f12b01abdc8acc5f3985
https://doi.org/10.1128/jvi.64.3.1192-1200.1990

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The implications of subunit interactions for the structure of the T cell receptor-CD3 complex

Autor: W L Maloy, F Koning, John E. Coligan

Publikováno v: European Journal of Immunology. 20:299-305

Cell surface-expressed receptors are often multichain complexes. One of these, the T cell receptor (TcR) alpha/beta-CD3 complex, is known to contain at least seven chains: the alpha and beta TcR chains plus the gamma, delta, epsilon and two zeta chai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a84a21eb6801f2b9ed0eb1391942ea
https://doi.org/10.1002/eji.1830200211

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