Zobrazeno 1 - 10
of 33
pro vyhledávání: '"W. L. Hand"'
Publikováno v:
Antimicrobial Agents and Chemotherapy. 37:2557-2562
Dirithromycin, a new macrolide antibiotic, achieves prolonged, high levels in tissue. We previously demonstrated that certain macrolides are highly concentrated within phagocytic cells. This background information prompted us to evaluate the interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5fa42eda3a61ea03b3bd7aa85d02d4
https://doi.org/10.1128/aac.37.12.2557
https://doi.org/10.1128/aac.37.12.2557
Publikováno v:
The Journal of Immunology. 149:2749-2758
An agonist-activated phospholipase D/phosphatidic acid phosphohydrolase (PAH) pathway was recently demonstrated in human neutrophils, and evidence suggests that phosphatidic acid (PA) and/or diradylglycerol (DG) generated from this pathway participat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b32e4cb3ee2baf32df74273f1d57c1d3
https://doi.org/10.4049/jimmunol.149.8.2749
https://doi.org/10.4049/jimmunol.149.8.2749
Autor:
W L Hand, Neva L. King-Thompson
Publikováno v:
Antimicrobial Agents and Chemotherapy. 34:1189-1193
Enucleated human polymorphonuclear leukocytes (PMN cytoplasts), which have no nuclei and only a few granules, retain many of the functions of intact neutrophils. To better define the mechanisms and intracellular sites of antimicrobial agent accumulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5adab8a4b3e75066e2c5804d2c9716c4
https://doi.org/10.1128/aac.34.6.1189
https://doi.org/10.1128/aac.34.6.1189
Publikováno v:
Antimicrobial Agents and Chemotherapy. 34:863-870
Recently we found that certain antibiotics which are markedly concentrated by human polymorphonuclear leukocytes (PMN) failed to kill susceptible, intraphagocytic Staphylococcus aureus, even though cellular drug levels were quite high. The possibilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc2352099ee15014d8eb48ff501f792
https://doi.org/10.1128/aac.34.5.863
https://doi.org/10.1128/aac.34.5.863
Publikováno v:
Antimicrobial agents and chemotherapy. 39(7)
Pentoxifylline modulates multiple activities of stimulated polymorphonuclear neutrophils (PMNs), including the respiratory burst response and membrane transport of certain substances (e.g., nucleosides). We found that several weakly basic antibiotics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6861637ade8778205fe655515490a0b
https://pubmed.ncbi.nlm.nih.gov/7492107
https://pubmed.ncbi.nlm.nih.gov/7492107
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 149(8)
An agonist-activated phospholipase D/phosphatidic acid phosphohydrolase (PAH) pathway was recently demonstrated in human neutrophils, and evidence suggests that phosphatidic acid (PA) and/or diradylglycerol (DG) generated from this pathway participat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17a309a3e27c853c4cda02d04c5f4bc3
https://pubmed.ncbi.nlm.nih.gov/1328385
https://pubmed.ncbi.nlm.nih.gov/1328385
Publikováno v:
Infection and Immunity. 57:3520-3526
Pentoxifylline is known to have major effects on cell membrane function in mammalian cells, including human leukocytes. The protective effects of this agent in animal models of infection and inflammation may be due to alterations in phagocyte (neutro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd1579c7d2fa1c55d349c0ee30fc3b28
https://doi.org/10.1128/iai.57.11.3520-3526.1989
https://doi.org/10.1128/iai.57.11.3520-3526.1989
Autor:
W L Hand
Publikováno v:
Infection and Immunity. 44:465-468
Sickle cell anemia and other chronic hemolytic anemias are associated with an increased frequency of bacterial infections. There is evidence to suggest that in hemolytic states massive erythrocyte (RBC) ingestion by macrophages interferes with their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f6338b10da9021afc1e9f0f1f6f5e4
https://doi.org/10.1128/iai.44.2.465-468.1984
https://doi.org/10.1128/iai.44.2.465-468.1984
Autor:
W L Hand, J R Cantey
Publikováno v:
Journal of Clinical Investigation. 53:354-362
Immunoglobulin synthesis and secretion have been studied in the rabbit lower respiratory tract, both in the normal state and after infection with Diplococcus pneumoniae or Listeria monocytogenes. In vitro synthesis of immunoglobulin and specific anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda0ebc8ba5a8ef10f0acf529a705cdf
https://doi.org/10.1172/jci107567
https://doi.org/10.1172/jci107567
Autor:
N L King-Thompson, W L Hand
Publikováno v:
Antimicrobial Agents and Chemotherapy. 21:241-247
The use of antibiotics which can penetrate phagocytic cells and kill intracellular organisms is desirable in the treatment of chronic facultative bacterial infections. Recently, we reported that several antibiotics were selectively concentrated by ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8365f6f47c6170d36530961276377409
https://doi.org/10.1128/aac.21.2.241
https://doi.org/10.1128/aac.21.2.241