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Interferon-gamma suppresses T-cell proliferation to mitogen via the nitric oxide pathway during experimental acute graft-versus-host disease

Autor: W Krenger, G Falzarano, J Jr Delmonte, KM Snyder, JC Byon, JL Ferrara

Publikováno v: Blood. 88:1113-1121

The development of graft-versus-host disease (GVHD) is associated with long-lasting and profound deficits in immune function that lead to increased morbidity and mortality after bone marrow transplantation (BMT). We investigated a mechanism of T-cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1b075134168a04c23fa87c5088697a3
https://doi.org/10.1182/blood.v88.3.1113.bloodjournal8831113

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Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease

Autor: W Krenger, K M Snyder, J C Byon, G Falzarano, J L Ferrara

Publikováno v: The Journal of Immunology. 155:585-593

Acute graft-vs-host disease (GVHD) is thought to be mediated by alloreactive T cells with a type 1 cytokine phenotype. To prevent the development of acute GVHD, we have successfully polarized mature donor T cells toward a type 2 cytokine phenotype ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24130a62a1ad120d6bed26eb76b2b854
https://doi.org/10.4049/jimmunol.155.2.585

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[Foreign and self--the challenge for the immune system]

Autor: W, Krenger

Publikováno v: Praxis. 96(6)

This process of thymic selection produces a repertoire of T-cells able to recognize foreign antigens but to remain nonreactive to the body's own antigens, designated "self" (central tolerance). The interaction between lymphoid and stromal cells withi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d56f597b45b32daeda8289cc1c8a07af
https://pubmed.ncbi.nlm.nih.gov/17330411

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