The bone lining cell: its role in cleaning Howship's lacunae and initiating bone formation

Autor: Paul Saftig, W. Beertsen, D. C. Jansen, Vincent Everts, Wikky Tigchelaar-Gutter, W. Korper, Jean-Marie Delaissé

Publikováno v: Journal of Bone and Mineral Research, 17, 77-90. American Society for Bone and Mineral Research
Journal of Bone and Mineral Research, 17, 77-90. Wiley-Blackwell
Journal of bone and mineral research, 17(1), 77-90. Wiley-Blackwell
Everts, V, Delaisse, J M, Korper, W, Saftig, P & Beertsen, W 2002, ' The bone lining cell: its role in cleaning Howship's lacunae and initiating bone formation ', Journal of Bone and Mineral Research, vol. 17, pp. 77-90 . https://doi.org/10.1359/jbmr.2002.17.1.77

In this study we investigated the role of bone lining cells in the coordination of bone resorption and formation. Ultrastructural analysis of mouse long bones and calvariae revealed that bone lining cells enwrap and subsequently digest collagen fibri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74bf89834d19172be1a15e2c285c87d
https://hdl.handle.net/11245/1.195821

Matrix metalloproteinase inhibitors block osteoclastic resorption of calvarial bone but not the resorption of long bone

Autor: Vincent Everts, W. Korper, W. Beertsen, Andrew J. P. Docherty

Publikováno v: Everts, V, Korper, W, Docherty, A J P & Beertsen, W 1999, ' Matrix metalloproteinase inhibitors block osteoclastic resorption of calvarial bone but not the resorption of long bone ', Annals of the New York Academy of Sciences, vol. 878, pp. 603-606 . https://doi.org/10.1111/j.1749-6632.1999.tb07739.x
Annals of the New York Academy of Sciences, 878, 603-606. Wiley-Blackwell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5235814ffc5461c2d7387c5f2ab45335
https://doi.org/10.1111/j.1749-6632.1999.tb07739.x

Type VI collagen is phagocytosed by fibroblasts and digested in the lysosomal apparatus: involvement of collagenase, serine proteinases and lysosomal enzymes

Autor: Ineke D. C. Jansen, Anneke Niehof, W. Korper, Wouter Beertsen, Vincent Everts

Publikováno v: Matrix biology, 14(8), 665-676. Elsevier

Type VI collagen is present in most connective tissues, where it is considered to play a crucial role in the attachment of cells to the extracellular matrix and/or in the three-dimensional organization of the collagen meshwork. Although some informat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9baae3e88cf936549a9d8ba922086f9
https://doi.org/10.1016/s0945-053x(05)80030-7

Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone

Autor: Paul Saftig, Vincent Everts, Dieter Brömme, Sylvia Heeneman, Kitty B.J.M. Cleutjens, Christoph Peters, Kees A. Hoeben, Thomas Reinheckel, W. Beertsen, Ineke D. C. Jansen, W. Korper

Publikováno v: Journal of Bone and Mineral Research, 21(9), 1399-1408. Wiley-Blackwell
Journal of bone and mineral research, 21(9), 1399-1408. Wiley-Blackwell
Journal of Bone and Mineral Research, 21(9), 1399-1408. American Society for Bone and Mineral Research
Everts, V, Korper, W, Hoeben, K A, Jansen, I D C, Bromme, D, Cleutjens, K B J M, Heeneman, S, Peters, C, Reinheckel, T, Saftig, P & Beertsen, W 2006, ' Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone ', Journal of Bone and Mineral Research, vol. 21, no. 9, pp. 1399-1408 . https://doi.org/10.1359/jbmr.060614

Osteoclastic bone degradation involves the activity of cathepsin K. We found that in addition to this enzyme other, yet unknown, cysteine proteinases participate in digestion. The results support the notion that osteoclasts from different bone sites

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beff3ed5958943d19e7d3eee4b713207
https://dare.uva.nl/personal/pure/en/publications/osteoclastic-bone-degradation-and-the-role-of-different-cysteine-proteinases-and-matrix-metalloproteinases-differences-between-calvaria-and-long-bone(6779ee6e-97d3-43ed-afe3-a68bea98b087).html

Degradation of collagen in the bone-resorbing compartment underlying the osteoclast involves both cysteine-proteinases and matrix metalloproteinases

Autor: V, Everts, J M, Delaissé, W, Korper, A, Niehof, G, Vaes, W, Beertsen

Publikováno v: Journal of cellular physiology. 150(2)

The site of action of cysteine-proteinases (CPs) and matrix metalloproteinases (MMPs) in the degradation of bone collagen by osteoclasts was investigated by evaluating the effects of the CP-inhibitor trans-epoxy-succinyl-L-leucylamido (4-guanidino)-b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::35af94431ca21a46bbbbfbedf1cee2e2
https://pubmed.ncbi.nlm.nih.gov/1734028