Zobrazeno 1 - 10
of 15
pro vyhledávání: '"W. Kirby Gottschalk"'
Publikováno v:
Frontiers in Systems Biology, Vol 3 (2023)
The principles governing genotype-phenotype relationships are still emerging (Jovanovic, Science, 2015, 347 (6,226), 1,259,038; Buccitelli et al., Nature Reviews Genetics, 2020, 21 (10), 630–44; Öztürk et al., Nature Communications, 2022, 131), 6
Externí odkaz:
https://doaj.org/article/63718dbc7b784b55af19e1a001c8434a
Autor:
Joan G. Wilson, M. Arthur Moseley, Carol A. Colton, W. Kirby Gottschalk, Kendra J. Adams, David S. Millington, J. Will Thompson
Publikováno v:
Journal of the American Society for Mass Spectrometry. 32:1448-1458
Immune-based metabolic reprogramming of arginine utilization in the brain contributes to the neuronal pathology associated with Alzheimer's disease (AD). To enable our long-term goals of differentiation of AD mouse model genotypes, ages, and sexes ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d4ae9b614df768d582064623fa01f4
https://doi.org/10.1021/jasms.1c00055
https://doi.org/10.1021/jasms.1c00055
Autor:
Michael W. Lutz, Kendra J. Adams, Gauri Kamat, Sayan Mukherjee, Jordan Bryan, Carol A. Colton, Alzheimer’s Disease Neuroimaging Initiative, W. Kirby Gottschalk, Alexandra Badea, Arpita Mandan, J. Will Thompson
Publikováno v:
Alzheimers Dement
Introduction The study of Alzheimer's disease (AD) has revealed biological pathways with implications for disease neuropathology and pathophysiology. These pathway-level effects may also be mediated by individual characteristics or covariates such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025ff3b6d5b1858d9769bb35e3512b6d
https://pubmed.ncbi.nlm.nih.gov/33480182
https://pubmed.ncbi.nlm.nih.gov/33480182
Autor:
Shuhong Luo, Isaac Ng, Allen D. Roses, Sonal Gagrani, Lefko Charlambous, Daniel L. Rock, Mirta Mihovilovic, Ann M. Saunders, W. Kirby Gottschalk, Kahli Zeitlow
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1863:2973-2986
A variable-length poly-T variant in intron 6 of the TOMM40 gene, rs10524523, is associated with risk and age-of-onset of sporadic (late-onset) Alzheimer's disease. In Caucasians, the three predominant alleles at this locus are Short (S), Long (L) or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b7b3caa23eb302bff1896f33c4220e
https://doi.org/10.1016/j.bbadis.2017.07.031
https://doi.org/10.1016/j.bbadis.2017.07.031
Autor:
Ann M. Saunders, Daniel L. Rock, Kahli Zietlow, Allen D. Roses, Isaac Ng, Mirta Mihovilovic, Lefko T Charalambous, Shuhong Luo, Sonal Gagrani, W. Kirby Gottschalk
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1864:1216
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b07b426536c98919e160b9937f96a283
https://doi.org/10.1016/j.bbadis.2018.01.017
https://doi.org/10.1016/j.bbadis.2018.01.017
Publikováno v:
Biochemical and Biophysical Research Communications. 189:906-911
Insulin-like growth factor 1 (IGF-1) had no detectable effect on pyruvate dehydrogenase (PDH) in NIH 3T3 cells that stably overexpressed normal human IGF-1 receptors. Insulin stimulated PDH activity 3–4 — fold in cells that overexpressed normal h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c66fdad1f6c2e799dbde93c61141e4
https://doi.org/10.1016/0006-291x(92)92289-a
https://doi.org/10.1016/0006-291x(92)92289-a
Autor:
Ornit Chiba-Falek, Anthony Akkari, W. Kirby Gottschalk, Allen D. Roses, Robert Saul, Scott S. Sundseth, Michael A. Hauser, Daniel K. Burns, Stephanie M. Roses, R. Rand Allingham, Ann M. Saunders, Dmitry Goldgaber, Michael W. Lutz, Keith E. Whitfield, Kathleen A. Welsh-Bohmer, Alexander A. Vostrov
Publikováno v:
Alzheimer's & Dementia. 10(6):592-601.e2
Background Several studies have demonstrated a lower apolipoprotein E4 ( APOE e4) allele frequency in African-Americans, but yet an increased age-related prevalence of AD. An algorithm for prevention clinical trials incorporating TOMM40'523 (Transloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2480c28507e88e27060d5c471efaaa
Publikováno v:
Experimental Mycology. 5:1-14
A quantitative bioassay for Blastocladiella emersonii zoospore maintenance factor (ZMF) is documented analyzed. The basis of the assay is an antagonistic interaction between NaCl and ZMF; the former elicits rapid encystment in zoospore populations wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7de4418a797df013716cf192beaba57b
https://doi.org/10.1016/0147-5975(81)90002-5
https://doi.org/10.1016/0147-5975(81)90002-5
Autor:
Iris Grossman, W. Kirby Gottschalk, Michael W. Lutz, Donna G. Crenshaw, Allen D. Roses, Ann M. Saunders
Publikováno v:
Alzheimer's & Dementia. (2):132-136
A number of recent studies have not replicated the association of the translocase of the outer mitochondrial membrane pore subunit (TOMM40) rs10524523 polymorphism, which is in linkage disequilibrium with apolipoprotein E (APOE), with age of onset of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f2ac6d86f10ea6714432db7f23bbb4
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