Zobrazeno 1 - 10
of 118
pro vyhledávání: '"W. Kessels"'
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-33 (2024)
Abstract Some individuals are able to maintain their cognitive abilities despite the presence of significant Alzheimer’s Disease (AD) neuropathological changes. This discrepancy between cognition and pathology has been labeled as resilience and has
Externí odkaz:
https://doaj.org/article/366a52247abc420094a7a727d47c1fd6
Autor:
Ivone M. Martins, Alexandre Lima, Wim de Graaff, Joana S. Cristóvão, Niek Brosens, Eleonora Aronica, Leon D. Kluskens, Cláudio M. Gomes, Joana Azeredo, Helmut W. Kessels
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-8 (2024)
Abstract Oligomeric clusters of amyloid-β (Aβ) are one of the major biomarkers for Alzheimer’s disease (AD). However, proficient methods to detect Aβ-oligomers in brain tissue are lacking. Here we show that synthetic M13 bacteriophages displayin
Externí odkaz:
https://doaj.org/article/2e0eb88b678d4731b983a499182ac95e
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Our knowledge on synaptic transmission in the central nervous system has often been obtained by evoking synaptic responses to populations of synapses. Analysis of the variance in synaptic responses can be applied as a method to predict whether a chan
Externí odkaz:
https://doaj.org/article/3c0a6d33a1764686ad7d746255c1000f
Autor:
Tong Zhang, Nshunge Musheshe, Christina H. J. T. M. van der Veen, Helmut W. Kessels, Amalia Dolga, Peter De Deyn, Ulrich Eisel, Martina Schmidt
Publikováno v:
Biomedicines, Vol 11, Iss 8, p 2096 (2023)
Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by amyloid beta (Aβ) and hyperphosphorylated tau accumulation in the brain. Recent studies indicated that memory retrieval, rather than memory formatio
Externí odkaz:
https://doaj.org/article/2260c534bec04fd09a43fb78a12267cb
Autor:
Stefanie de Groot, Rieneke T. Lugtenberg, Danielle Cohen, Marij J. P. Welters, Ilina Ehsan, Maaike P. G. Vreeswijk, Vincent T. H. B. M. Smit, Hiltje de Graaf, Joan B. Heijns, Johanneke E. A. Portielje, Agnes J. van de Wouw, Alex L. T. Imholz, Lonneke W. Kessels, Suzan Vrijaldenhoven, Arnold Baars, Elma Meershoek-Klein Kranenbarg, Marjolijn Duijm-de Carpentier, Hein Putter, Jacobus J. M. van der Hoeven, Johan W. R. Nortier, Valter D. Longo, Hanno Pijl, Judith R. Kroep, Dutch Breast Cancer Research Group (BOOG)
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Preclinical evidence suggests that a fasting mimicking diet (FMD) can make cancer cells more vulnerable to chemotherapy, while protecting normal cells. In this randomized phase II clinical trial of 131 patients with HER2 negative early stage breast c
Externí odkaz:
https://doaj.org/article/ece7e746301b495eb80ac3a814697099
Autor:
Fabrizio Grieco, Briana J. Bernstein, Barbara Biemans, Lior Bikovski, C. Joseph Burnett, Jesse D. Cushman, Elsbeth A. van Dam, Sydney A. Fry, Bar Richmond-Hacham, Judith R. Homberg, Martien J. H. Kas, Helmut W. Kessels, Bastijn Koopmans, Michael J. Krashes, Vaishnav Krishnan, Sreemathi Logan, Maarten Loos, Katharine E. McCann, Qendresa Parduzi, Chaim G. Pick, Thomas D. Prevot, Gernot Riedel, Lianne Robinson, Mina Sadighi, August B. Smit, William Sonntag, Reinko F. Roelofs, Ruud A.J. Tegelenbosch, Lucas P.J.J. Noldus
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2021)
The reproducibility crisis (or replication crisis) in biomedical research is a particularly existential and under-addressed issue in the field of behavioral neuroscience, where, in spite of efforts to standardize testing and assay protocols, several
Externí odkaz:
https://doaj.org/article/e6fe0375a48847e8ab15ebea282102ec
Autor:
Stefanie de Groot, Hanno Pijl, Ayoub Charehbili, Saskia van de Ven, Vincent T. H. B. M. Smit, Elma Meershoek-Klein Kranenbarg, Joan B. Heijns, Laurence J. C. van Warmerdam, Lonneke W. Kessels, M. Wouter Dercksen, Manon J. A. E. Pepels, Hanneke W. M. van Laarhoven, Birgit E. P. J. Vriens, Hein Putter, Marta Fiocco, Gerrit-Jan Liefers, Jacobus J. M. van der Hoeven, Johan W. R. Nortier, Judith R. Kroep, on behalf of the Dutch Breast Cancer Research Group
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-9 (2019)
Abstract Background Adjuvant bisphosphonates are associated with improved breast cancer survival in postmenopausal patients. Addition of zoledronic acid (ZA) to neoadjuvant chemotherapy did not improve pathological complete response in the phase III
Externí odkaz:
https://doaj.org/article/a99967db5d734f59a7bddc08f547d2ce
Autor:
Sylvie L. Lesuis, Lianne Hoeijmakers, Aniko Korosi, Susanne R. de Rooij, Dick F. Swaab, Helmut W. Kessels, Paul J. Lucassen, Harm J. Krugers
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-20 (2018)
Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with a high prevalence among the elderly and a huge personal and societal impact. Recent epidemiological studies have indicated that the incidence and age of o
Externí odkaz:
https://doaj.org/article/a2b5f03bb3de424984b5908246247281
Autor:
Seçil Uyaniker, Sophie J. F. van der Spek, Niels R. Reinders, Hui Xiong, Ka Wan Li, Koen Bossers, August B. Smit, Joost Verhaagen, Helmut W. Kessels
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Viral vectors are attractive tools to express genes in neurons. Transduction of neurons with a recombinant, replication-deficient Sindbis viral vector is a method of choice for studying the effects of short-term protein overexpression on neuronal fun
Externí odkaz:
https://doaj.org/article/233e6a5cde484e82963af248cf19de16
Autor:
Stefan Sleijfer, John A. Foekens, John W.M. Martens, Anieta M. Sieuwerts, Jan W. Gratama, Cornelis J.H. van de Velde, Monique M.E.M. Bos, Hanneke W.M. van Laarhoven, Lonneke W. Kessels, Joan B. Heijns, Saskia van de Ven, Johan W.R. Nortier, Judith R. Kroep, Vincent T.H.B.M. Smit, Ayoub Charehbili, Mieke M. Timmermans, Bianca Mostert, Jaco Kraan, Wendy Onstenk
Clinicopathological characteristics, CTC and CEC counts, and primary tumor EpCAM and MCAM staining specified per patient.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e8ae48db5d6c608aef49e3bf32fef5
https://doi.org/10.1158/1535-7163.22502670.v1
https://doi.org/10.1158/1535-7163.22502670.v1