Zobrazeno 1 - 10
of 510
pro vyhledávání: '"W. KAPPLER"'
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has lasted more than 2 years with over 260 million infections and 5 million deaths worldwide as of November 2021. To combat the virus, monoclonal antibodies blocking the virus
Externí odkaz:
https://doaj.org/article/9a47f7c628cd4a90a8fc815652ad01cf
Autor:
Haolin Liu, Pengcheng Wei, Katja Aviszus, Qianqian Zhang, Jared Linderberger, John Yang, Junfeng Liu, Zhongzhou Chen, Hassan Waheed, Lyndon Reynoso, Gregory P. Downey, Stephen K. Frankel, John W. Kappler, Philippa Marrack, Gongyi Zhang
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11325 (2022)
The SARS-CoV-2 Delta and Lambda variants had been named variants of concern (VOC) and variants of interest (VOI), respectively, by the World Health Organization (WHO). Both variants have two mutations in the spike receptor binding domain (RBD) region
Externí odkaz:
https://doaj.org/article/0f5e8372cbc146c893b2238a90999b2a
Autor:
Brendan K. Reed, John W. Kappler
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The T cell antigens driving autoimmune Type 1 Diabetes (T1D) have been pursued for more than three decades. When diabetogenic CD4 T cell clones and their relevant MHCII antigen presenting alleles were first identified in rodents and humans, the path
Externí odkaz:
https://doaj.org/article/ea66b09c17dd4ef2a8efed330a2a7481
Autor:
Peng Bai, Yongzheng Li, Qiuping Zhou, Jiaqi Xia, Peng-Cheng Wei, Hexiang Deng, Min Wu, Sanny K. Chan, John W. Kappler, Yu Zhou, Eric Tran, Philippa Marrack, Lei Yin
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Genetic mutations lead to the production of mutated proteins from which peptides are presented to T cells as cancer neoantigens. Evidence suggests that T cells that target neoantigens are the main mediators of effective cancer immunotherapies. Althou
Externí odkaz:
https://doaj.org/article/c96423e775ad49e891b21b02b46d9459
Autor:
Joseph Ray Cepeda, Nitin S Sekhar, Junying Han, Wei Xiong, Ningyan Zhang, Liping Yu, Shaodong Dai, Howard W. Davidson, John W. Kappler, Zhiqiang An, Li Zhang
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Activation of T cells specific for insulin B chain amino acids 9 to 23 (B:9–23) is essential for the initiation of type 1 diabetes (T1D) in non-obese diabetic mice. We previously reported that peptide/MHC complexes containing optimized B:9–23 mim
Externí odkaz:
https://doaj.org/article/72ce24d0357c4b38886ed579e0584dd3
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0213052 (2019)
Lipocalins represent the most important protein family of the mammalian respiratory allergens. Four of the seven named dog allergens are lipocalins: Can f 1, Can f 2, Can f 4, and Can f 6. We present the structure of Can f 6 along with data on the bi
Externí odkaz:
https://doaj.org/article/212073fee6444221849050dc236f5742
Autor:
John W. Kappler, Hua Bai, Philippa Marrack, Qiuping Zhou, Peng Bai, Sanny K. Chan, Pengcheng Wei, Lei Yin
Publikováno v:
Science China Life Sciences. 64:2144-2152
Cytotoxic T cells targeting cancer neoantigens harboring driver mutations can lead to durable tumor regression in an HLAI-dependent manner. However, it is difficult to extend the population of patients who are eligible for neoantigen-based immunother
Autor:
Megan K. L. MacLeod, Jennifer L. Matsuda, Shaima Al Khabouri, Laurent Gapin, F. Morton, Paul Garside, John W. Kappler, Phillipa Marrack, Eric T. Clambey, Joshua I. Gray, Thomas D. Otto
Publikováno v:
Immunology
We have examined the response of memory CD4 T cells to tolerogenic signals. Although memory CD4 T cells could respond to antigen delivered without adjuvant, they undergo cell death upon further restimulation. Our data suggest that the Tcells die as a
Autor:
Kira Rubtsova, Anatoly V Rubtsov, Kalani Halemano, Sam X Li, John W Kappler, Mario L Santiago, Philippa Marrack
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166322 (2016)
Knowledge of the processes that underlie IgG subclass switching could inform strategies designed to counteract infections and autoimmunity. Here we show that TLR7 ligands induce subsets of memory CD4 and CD8 T cells to secrete interferon γ (IFNγ) i
Externí odkaz:
https://doaj.org/article/3291481214dc474f89bec8bd87f8082c
Autor:
Qianqian Zhang, Gongyi Zhang, Philippa Marrack, Zhongzhou Chen, Tengyao Song, Srinivas Ramachandran, Thomas Danhorn, Haolin Liu, John W. Kappler, Carrie Happoldt, Xinjian Liu, Tzu L. Phang, Ting-Hui Tu, Nova Fong, Ralf Janknecht, Sangphil Oh, Pirooz V. Parsa, Laura Harmacek, Qian Zhang, Brian O’Conner, Schuyler Lee, Chuan-Yuan Li, Sonia M. Leach
Publikováno v:
Proc Natl Acad Sci U S A
More than 30% of genes in higher eukaryotes are regulated by RNA polymerase II (Pol II) promoter proximal pausing. Pausing is released by the positive transcription elongation factor complex (P-TEFb). However, the exact mechanism by which this occurs