Výsledky vyhledávání - "W. K. Sawyer"

ACE inhibition versus angiotensin II, AT1 receptor antagonism: A review of effects on intimal lesion formation in animal models of vascular injury, restenosis, and atherosclerosis

Autor: Margaret F. Prescott, W. K. Sawyer

Publikováno v: Drug Development Research. 29:88-93

We recently demonstrated that the angiotensin converting enzyme inhibitor (ACEi) benazepril reduced balloon-induced lesion formation solely by inhibiting smooth muscle cell (SMC) migration, whereas the Ang II, AT1 antagonist losartan reduced lesion f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d50111b537a32c8fdfcb40a7927c219
https://doi.org/10.1002/ddr.430290204

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Evaluating Barnett Shale Production Performance Using an Integrated Approach

Autor: J. H. Frantz, J. R. Williamson, W. K. Sawyer, D. Johnston, G. Waters, L. P. Moore, R. J. MacDonald, M. Pearcy, S. V. Ganpule, K. S. March

Publikováno v: All Days.

This paper presents the results of using a shale-specific, finite-difference reservoir simulation model to history match and forecast production data from the Barnett Shale reservoir. The paper will illustrate the many uses of the model for vertical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2339cbe61e89f427f6a2edd9acc4ab3
https://doi.org/10.2118/96917-ms

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CGP 43371 paradoxically inhibits development of rabbit atherosclerotic lesions while inducing extra-arterial foam cell formation

Autor: David Louis Feldman, Michael Jeune, Therese C Mogelesky, Margaret F. Prescott, Jean Von Linden-Reed, W. K. Sawyer

Publikováno v: Atherosclerosis. 154(2)

Ansamycins are hypolipidemic compounds which, when administered to various animal species, dramatically lower high density lipoprotein (HDL) cholesterol levels, in addition to reducing the levels of other lipoprotein classes. The current study tested

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1644d55674611f6f35540199428236be
https://pubmed.ncbi.nlm.nih.gov/11166764

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Effect of matrix metalloproteinase inhibition on progression of atherosclerosis and aneurysm in LDL receptor-deficient mice overexpressing MMP-3, MMP-12, and MMP-13 and on restenosis in rats after balloon injury

Autor: Michael Jeune, Shari L. Caplan, Mary Chou, Jean Von Linden-Reed, Margaret F. Prescott, Arco Y. Jeng, W. K. Sawyer

Publikováno v: Annals of the New York Academy of Sciences. 878

The broad-spectrum MMP inhibitor CGS 27023A was tested to determine its potential as a therapy for atherosclerosis, aneurysm, and restenosis. LDL receptor-deficient (LDLr -/-) mice fed a high-fat, cholic acid-enriched diet for 16 weeks developed adva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f57f77b797b5950e43bdd09c6efea87
https://pubmed.ncbi.nlm.nih.gov/10415729

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Effect of a novel series of macrocyclic hypolipidemic agents on plasma lipid and lipoprotein levels of four non-primate species

Autor: P Traxler, S Veenstra, Joyce C. Gibson, B Mugrage, Warren Lee, H.V. Kothari, T M Genthe, M Grim, W. K. Sawyer, K J Poirier

Publikováno v: Atherosclerosis. 96(2-3)

The ansamycins are structurally novel hypolipidemic agents derived from rifampicin, but lacking antibacterial activity. Oral or intravenous administration resulted in rapid lowering of plasma cholesterol in rats, hamsters, guinea pigs and dogs. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e7e72a2659d67349c8a595e6a06b3c
https://pubmed.ncbi.nlm.nih.gov/1466647

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In vitro and in vivo studies demonstrating potent and selective estrogen inhibition with the nonsteroidal aromatase inhibitor CGS 16949A

Autor: Jong M. Wasvary, Steele Ronald Edward, Lynn B. Mellor, Leslie J. Browne, W. K. Sawyer

Publikováno v: Steroids. 50:147-161

CGS 16949A inhibited the conversion of [4-14C]androstenedione (A) to [4-14C]estrone by human placental microsomes in a competitive manner (Ki = 1.6 nM). Aminoglutethimide, also a competitive inhibitor, had a Ki = 0.7 microM in this assay system. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc18ab4458a65ebebf7148a211ddaa3
https://doi.org/10.1016/0039-128x(83)90068-5

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RELAXIN BIOACTIVITY AND IMMUNOACTIVITY IN HUMAN CORPORA LUTEA1

Autor: E. Milikin O'byrne, W. K. Sawyer, Gerson Weiss, J.F. Flitcraft, J. Hochman, Bernard G. Steinetz

Publikováno v: Endocrinology. 102:1641-1644

Relaxin-like activity in extracts of corpora lutea (CL) from pregnant and non-pregnant women was determined by radioimmunoassay and by guinea pig pubic symphysis palpation assay. The biologically determined activity paralled the immunoactivity of ext

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbe85866355bc902cd8de93576aab93d
https://doi.org/10.1210/endo-102-5-1641

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