Zobrazeno 1 - 10 of 12 pro vyhledávání: '"W. K. HAGMANN"'
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Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones
Autor: S K, Shah, C P, Dorn, P E, Finke, J J, Hale, W K, Hagmann, K A, Brause, G O, Chandler, A L, Kissinger, B M, Ashe, H, Weston
Publikováno v: Journal of Medicinal Chemistry. 35:3745-3754
A thorough analysis of the mechanism of inhibition of human leukocyte elastase (HLE) by a monocyclic beta-lactam and the mechanism of beta-lactam hydrolysis led to the preparation of potent and highly stable inhibitors of HLE. This work led to the id
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451b2a8391952e9d8f09c0837d3d5f01
https://doi.org/10.1021/jm00099a003
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4
PMN elastases: a comparison of the specificity of human isozymes and the enzyme from other species toward substrates and inhibitors
Autor: H. Weston, W. K. Hagmann, S. K. Shah, Lori A. Walakovits, Alan L. Maycock, Michael W. Lark, Richard A. Mumford, Barbara G. Green, Vernon L. Moore, W. B. Knight, James B. Doherty, P. E. Finke, Bonnie M. Ashe, J. Mao
Publikováno v: Archives of biochemistry and biophysics. 286(1)
The human elastases isolated from polymorphonuclear neutrophils (PMN) and purulent sputum displayed identical kinetic constants toward substrates and inhibitors. The elastases from the two sources yield identical N-terminal sequences and were recogni
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a472656b95850b519b73aaabb2136a10
https://pubmed.ncbi.nlm.nih.gov/1897955
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6
Synthesis and antiinflammatory/analgesic activities of 11H-dibenzo[b, e,][1,4]dioxepinacetic acids
Autor: W K, Hagmann, C P, Dorn, R A, Frankshun, L A, O'Grady, P J, Bailey, A, Rackham, H W, Dougherty
Publikováno v: Journal of medicinal chemistry. 29(8)
A new class of tricyclic arylacetic acids was synthesized and evaluated as antiinflammatory/analgesic agents as well as inhibitors of prostaglandin synthetase. 11H-Dibenzo[b,e][1,4]dioxepin-2-, -3, -7, and -8-acetic and alpha-methylacetic acids and t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b3224ac77220a195f8c8ddfda62d43e5
https://pubmed.ncbi.nlm.nih.gov/3488405
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