α‐Halocarbonyls as a Valuable Functionalized Tertiary Alkyl Source.

Autor: Nishikata, Takashi¹ (AUTHOR) nisikata@yamaguchi-u.ac

Publikováno v: ChemistryOpen. Oct2024, Vol. 13 Issue 10, p1-72. 72p.

ChemInform Abstract: Orally Active β-Lactam Inhibitors of Human Leukocyte Elastase-1. Activity of 3,3-Diethyl-2-azetidinones

Autor: S. K. Shah, H. Weston, W. K. Hagmann, Richard A. Mumford, Karen A. Brause, J. B. Doherty, D. S. Fletcher, W. B. Knight, C. P. Jun. Dorn, Dennis J. Underwood, Pam S. Dellea, J. J. Hale, Amy L. Kissinger, P. E. Finke, Karen M. Hand, Alan L. Maycock, Bonnie M. Ashe, G. O. Chandler

Publikováno v: ChemInform. 24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6974db53a20907e71079b428ba03f87
https://doi.org/10.1002/chin.199320171

Total Syntheses of Streptamidine and Klebsazolicin Using Biomimetic On-Resin Ring-Closing Amidine Formation.

Autor: Liu S; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, P. R. China., Tang Y; Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong SAR, P. R. China., Chen S; Department of Food Science and Nutrition, State Key Lab of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, P. R. China., Li X; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, P. R. China.; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, P. R. China., Liu H; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, P. R. China.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Sep 16; Vol. 63 (38), pp. e202407952. Date of Electronic Publication: 2024 Aug 14.

PMN elastases: a comparison of the specificity of human isozymes and the enzyme from other species toward substrates and inhibitors

Autor: H. Weston, W. K. Hagmann, S. K. Shah, Lori A. Walakovits, Alan L. Maycock, Michael W. Lark, Richard A. Mumford, Barbara G. Green, Vernon L. Moore, W. B. Knight, James B. Doherty, P. E. Finke, Bonnie M. Ashe, J. Mao

Publikováno v: Archives of biochemistry and biophysics. 286(1)

The human elastases isolated from polymorphonuclear neutrophils (PMN) and purulent sputum displayed identical kinetic constants toward substrates and inhibitors. The elastases from the two sources yield identical N-terminal sequences and were recogni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a472656b95850b519b73aaabb2136a10
https://pubmed.ncbi.nlm.nih.gov/1897955

Design and Characterization of a Novel eEF2K Degrader with Potent Therapeutic Efficacy Against Triple‐Negative Breast Cancer.

Autor: Zhong, Changxin^1,2 (AUTHOR), Zhu, Rongfeng³ (AUTHOR), Jiang, Ting^1,2 (AUTHOR), Tian, Sheng³ (AUTHOR), Zhao, Xiaobao³ (AUTHOR), Wan, Xiaoya^1,2 (AUTHOR), Jiang, Shilong⁴ (AUTHOR), Chen, Zonglin^1,5 (AUTHOR), Gong, Rong^1,2 (AUTHOR), He, Linhao^1,2 (AUTHOR), Yang, Jin‐Ming⁶ (AUTHOR), Ye, Na³ (AUTHOR) yena@suda.edu.cn, Cheng, Yan^1,2,7 (AUTHOR) yancheng@csu.edu.cn

Publikováno v: Advanced Science. 2/2/2024, Vol. 11 Issue 5, p1-16. 16p.