Zobrazeno 1 - 10
of 32
pro vyhledávání: '"W. K. Eddie Ip"'
Publikováno v:
Science. 356:513-519
Interleukin 10 (IL-10) is an anti-inflammatory cytokine that plays a critical role in the control of immune responses. However, its mechanisms of action remain poorly understood. Here, we show that IL-10 opposes the switch to the metabolic program in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cb4a24c1fc66d084c19453de435480
https://doi.org/10.1126/science.aal3535
https://doi.org/10.1126/science.aal3535
Autor:
Jun Young Hong, Fernando Carvalho, Jaechul Lim, Ruslan Medzhitov, W. K. Eddie Ip, Charles Annicelli, Jen Young Cho, Bharat Vaidyanathan, Shuang Yu
Publikováno v:
Cell. 180:847-861.e15
Early life environmental exposure, particularly during perinatal period, can have a life-long impact on organismal development and physiology. The biological rationale for this phenomenon is to promote physiological adaptations to the anticipated env
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d2e961ab1083dfc13464fc3adf558b5
https://doi.org/10.1016/j.cell.2020.02.018
https://doi.org/10.1016/j.cell.2020.02.018
Autor:
Sivapriya Kailasan Vanaja, Antoine Tanne, Adam Lacy-Hulbert, Anna Sokolovska, Nicholas Paquette, W. K. Eddie Ip, Vijay A. K. Rathinam, Katherine A. Fitzgerald, Christine Becker, Lynda M. Stuart, Matthew Brudner, Kathryn J. Moore
Publikováno v:
Nature immunology
Phagocytosis is a fundamental cellular process that is pivotal for immunity as it coordinates microbial killing, innate immune activation and antigen presentation. An essential step in this process is phagosome acidification, which regulates many fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1b98e1c3f1006160803ae76772d68d
https://doi.org/10.1038/ni.2595
https://doi.org/10.1038/ni.2595
Autor:
Deniz Erturk-Hasdemir, Stephanie Dejardin, Lynda M. Stuart, Michael P. Cappillino, Guillaume M. Charrière, Nicholas Paquette, Neal S. Silverman, W. K. Eddie Ip, Elizabeth J. Hennessy, Adam Lacy-Hulbert, Laurent Boyer, Charlotte Hinault, Lorin Magoc, Jean-Marc Reichhart, Shannon Fracchia
Publikováno v:
Immunity. 35:536-549
SummaryAlthough infections with virulent pathogens often induce a strong inflammatory reaction, what drives the increased immune response to pathogens compared to nonpathogenic microbes is poorly understood. One possibility is that the immune system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::791b5170886cc6936a73b526301a85ee
https://doi.org/10.1016/j.immuni.2011.08.015
https://doi.org/10.1016/j.immuni.2011.08.015
Autor:
Stephanie Dejardin, Koichi Kobayashi, Lynda M. Stuart, Neal S. Silverman, Bobby J. Cherayil, Guillaume M. Charrière, W. K. Eddie Ip, Adam Lacy-Hulbert, Laurent Boyer, Michael P. Cappillino, Daniel K. Podolsky, Anna Sokolovska
Publikováno v:
Journal of Biological Chemistry. 285:20147-20154
NOD2 (nucleotide-binding oligomerization domain containing 2) is an important cytosolic pattern recognition receptor that activates NF-kappaB and other immune effector pathways such as autophagy and antigen presentation. Despite its intracellular loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a05b79e6106fc77fce47e6ac9458b8
https://doi.org/10.1074/jbc.m110.115584
https://doi.org/10.1074/jbc.m110.115584
Publikováno v:
Immunological Reviews. 230:9-21
Innate immunity is the earliest response to invading microbes and acts to contain infection in the first minutes to hours of challenge. Unlike adaptive immunity that relies upon clonal expansion of cells that emerge days after antigenic challenge, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f70f0613bb8f774002d44a0700ad331
https://doi.org/10.1111/j.1600-065x.2009.00789.x
https://doi.org/10.1111/j.1600-065x.2009.00789.x
Publikováno v:
The Journal of Experimental Medicine
Innate immunity is the first-line defense against pathogens and relies on phagocytes, soluble components, and cell-surface and cytosolic pattern recognition receptors. Despite using hard-wired receptors and signaling pathways, the innate immune respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3737a8928b96a496f890499343bb8ee
http://europepmc.org/articles/PMC2234382
http://europepmc.org/articles/PMC2234382
Autor:
Ruslan Medzhitov, W. K. Eddie Ip
Publikováno v:
Nature communications
Interstitial osmolality is a key homeostatic variable that varies depending on the tissue microenvironment. Mammalian cells have effective mechanisms to cope with osmotic stress by engaging various adaptation responses. Hyperosmolality due to high di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8325e9955d73c24ed4abb0f6055313ff
https://doi.org/10.1038/ncomms7931
https://doi.org/10.1038/ncomms7931
Autor:
L. Michael Yantosca, Michael P. Cappillino, Guillaume M. Charrière, Adam Lacy-Hulbert, Anna Sokolovska, Laurent Boyer, W. K. Eddie Ip, Kathryn J. Moore, Lynda M. Stuart, Stephanie Dejardin, Kazue Takahashi
Innate immunity is vital for protection from microbes and is mediated by humoral effectors, such as cytokines, and cellular immune defenses, including phagocytic cells (e.g., macrophages). After internalization by phagocytes, microbes are delivered i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00ff9fed6cb4dc6a185b71c7616e62d
https://europepmc.org/articles/PMC2935932/
https://europepmc.org/articles/PMC2935932/
Autor:
Charles J. Hinds, Gitte Kronborg, Mark J. Peters, Emma S. McBryde, Melinda M. Dean, Anthony C. Gordon, Jürgen F J Kun, Katy Fidler, Helgi Valdimarsson, J W Oliver van Till, W. K. Eddie Ip, Yu-Lung Lau, Damon P. Eisen, Marja A. Boermeester, Stephen J. Brett, Antonis Payeras, Joan Mila, Saedis Saevarsdottir
Publikováno v:
Clinical infectious diseases, 47(4), 510-516. Oxford University Press
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
BACKGROUND Previous studies have shown associations between low mannose-binding lectin (MBL) level or variant MBL2 genotype and sepsis susceptibility. However, MBL deficiency has not been rigorously defined, and associations with sepsis outcomes have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fb8509f306194a41bf3194e14cc3a2
https://pubmed.ncbi.nlm.nih.gov/18986266
https://pubmed.ncbi.nlm.nih.gov/18986266