Zobrazeno 1 - 10
of 70
pro vyhledávání: '"W. K. Cavenee"'
Autor:
S. Cheng, H. Feng, G. Y. Lopez, C. K. Kim, C. G. Duncan, A. Alvarez, R. Nishikawa, M. Nagane, A.-J. Su, P. E. Auron, M. L. Hedberg, L. Wang, J. R. Grandis, R. E. McLendon, D. D. Bigner, I. Nakano, K. Joshi, S. Kim, H.-K. Lin, F. B. Furnari, W. K. Cavenee, B. Hu, H. Yan, S.-Y. Cheng
BACKGROUND: Oncogenic EGFR-Akt signaling is aberrantly activated in human glioblastomas. Discoid, CUC and LCCL domain containing protein 2 (DCBLD2, also known as CLCP1 and ESDN) is a neuropilin-like membrane protein that is up-regulated in vascular i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b90fbb1477c636bbb6c87bea1edbf05
https://europepmc.org/articles/PMC4144529/
https://europepmc.org/articles/PMC4144529/
Autor:
P, Guo, L, Xu, S, Pan, R A, Brekken, S T, Yang, G B, Whitaker, M, Nagane, P E, Thorpe, J S, Rosenbaum, H J, Su Huang, W K, Cavenee, S Y, Cheng
Publikováno v:
Cancer research. 61(23)
The gene for the major angiogenic factor, vascular endothelial growth factor (VEGF), encodes several spliced isoforms. We reported previously that overexpression of two VEGF isoforms, VEGF(121) and VEGF(165), by human glioma U87 MG cells induced tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f50a5066f486e942fbe2c0e97d659054
https://pubmed.ncbi.nlm.nih.gov/11731444
https://pubmed.ncbi.nlm.nih.gov/11731444
Publikováno v:
Apoptosis : an international journal on programmed cell death. 6(3)
Innate and acquired resistance to chemotherapy and radiation therapy has been a major obstacle for clinical oncology. One potential adjunct to such conventional treatments is direct induction of cell death by activation of death receptor-mediated apo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c3468cfec744e3e140e13684f7e9e305
https://pubmed.ncbi.nlm.nih.gov/11388668
https://pubmed.ncbi.nlm.nih.gov/11388668
Publikováno v:
Journal of neuro-oncology. 46(1)
The PCAF gene encodes the p300/CBP-Associated Factor (PCAF), a histone acetyltransferase, which regulates p53 by acetylation of Lys320 in the C-terminal portion of p53. While the p53 gene is one of the most frequently mutated tumor suppressor genes i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c26d8d2c4295aadf57b009c7d183effc
https://pubmed.ncbi.nlm.nih.gov/10896202
https://pubmed.ncbi.nlm.nih.gov/10896202
Publikováno v:
Cancer research. 60(4)
The intractability of malignant gliomas to multimodality treatments plays a large part in their extremely poor prognosis. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a novel member of the tumor necrosis factor (TNF) family that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ffa55525b3c03c47fa6be449dc23fbe
https://pubmed.ncbi.nlm.nih.gov/10706092
https://pubmed.ncbi.nlm.nih.gov/10706092
Publikováno v:
Cancer research. 59(21)
Marked neovascularization and vascular endothelial proliferation are characteristic features of malignant gliomas. Vascular endothelial growth factor (VEGF), an angiogenic protein secreted by glioma cells, appears to play a crucial role for induction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::906a971819bd5800f843c82005c6da8e
https://pubmed.ncbi.nlm.nih.gov/10554042
https://pubmed.ncbi.nlm.nih.gov/10554042
Publikováno v:
Cancer research. 59(15)
Alteration of chromosome 10 is common in human melanomas and usually entails the loss of an entire chromosome homologue. Although the reasons for monosomy in cancer has remained obscure, one possibility is that multiple tumor suppressor genes residin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c3dfa8e5ae0f1bf977985f2573ed4c18
https://pubmed.ncbi.nlm.nih.gov/10446968
https://pubmed.ncbi.nlm.nih.gov/10446968
Publikováno v:
Cancer research. 59(10)
D-type cyclins regulate distinct cellular processes, such as mitotic cell cycle control, differentiation, and transcription. We have previously shown that the D-type cyclins are critical for the androgen-dependent proliferation of prostate cells. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1c4a08be1b7ce744e217be0ce58e771e
https://pubmed.ncbi.nlm.nih.gov/10344732
https://pubmed.ncbi.nlm.nih.gov/10344732
Publikováno v:
Cancer research. 59(7)
Increased numbers of platelet-derived growth factor beta receptors betaPPDGFRs) on neovascular endothelial cells is a common occurrence in several pathological conditions including wound healing, inflammation, and glioma tumorigenesis. Here we sought
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bb0b15731300de39ca655a16be4745c3
https://pubmed.ncbi.nlm.nih.gov/10197615
https://pubmed.ncbi.nlm.nih.gov/10197615
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 10(2)
The early incidence of p53 mutation in astrocytomas suggests that it plays an important role in astrocyte transformation. Astrocytes isolated from homozygous p53 knockout mice grow rapidly, lack contact inhibition, and are immortal. Here we tested wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c96958b3abedecfa1fdae67f42b3efee
https://pubmed.ncbi.nlm.nih.gov/10074901
https://pubmed.ncbi.nlm.nih.gov/10074901