Zobrazeno 1 - 8
of 8
pro vyhledávání: '"W. Joon Chung"'
Autor:
W Joon Chung, Jennifer L Goeckeler-Fried, Viktoria Havasi, Annette Chiang, Steven M Rowe, Zackery E Plyler, Jeong S Hong, Marina Mazur, Gary A Piazza, Adam B Keeton, E Lucile White, Lynn Rasmussen, Allan M Weissman, R Aldrin Denny, Jeffrey L Brodsky, Eric J Sorscher
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163615 (2016)
Small molecules that correct the folding defects and enhance surface localization of the F508del mutation in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) comprise an important therapeutic strategy for cystic fibrosis lung disease. H
Externí odkaz:
https://doaj.org/article/5aa68f888e6b4637be0734ba8a6e6965
Autor:
Michael S Stalvey, Katrina L Clines, Viktoria Havasi, Christopher R McKibbin, Lauren K Dunn, W Joon Chung, Gregory A Clines
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80098 (2013)
Low bone mass and increased fracture risk are recognized complications of cystic fibrosis (CF). CF-related bone disease (CFBD) is characterized by uncoupled bone turnover--impaired osteoblastic bone formation and enhanced osteoclastic bone resorption
Externí odkaz:
https://doaj.org/article/0a08f645dcbb406e8a23ede51729fcd8
Autor:
Louise C. Pyle, Steve Aller, Hal A. Lewis, Wei Wang, Eric J. Sorscher, Gergely L. Lukacs, Shane Atwell, Christine E. Bear, W. Joon Chung, Annette Ehrhardt, Kryzysztof Nowotarski, Kevin L. Kirk, Cory M. Mulvihill, Jeong S. Hong, Mohabir Ramjeesingh, Sadanandan E. Velu
Publikováno v:
Journal of Biological Chemistry. 291:1854-1865
In this study, we present data indicating a robust and specific domain interaction between the cystic fibrosis transmembrane conductance regulator (CFTR) first cytosolic loop (CL1) and nucleotide binding domain 1 (NBD1) that allows ion transport to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e67c85caf3010f2c2149f230fd0fb4
https://doi.org/10.1074/jbc.m115.704809
https://doi.org/10.1074/jbc.m115.704809
Autor:
Carleen M. Sabusap, Hui Wen, W. Joon Chung, Marina Mazur, Lianwu Fu, Kevin L. Kirk, James F. Collawn, Eric J. Sorscher, Jeong S. Hong, Wei Wang, Carmel M. McNicholas
Publikováno v:
JCI insight. 1(14)
Emerging knowledge indicates the difficulty in categorizing unusual cystic fibrosis (CF) mutations, with regard to both pathogenic mechanism and theratype. As case in point, we present data concerning P67L mutation of the cystic fibrosis transmembran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2e721e1ebe75236eeb9565728cddc1
https://pubmed.ncbi.nlm.nih.gov/27660821
https://pubmed.ncbi.nlm.nih.gov/27660821
Autor:
W. Joon Chung, Harald Sontheimer
Publikováno v:
Journal of neurochemistry. 110(1)
Nuclear factor-kappaB (NF-kappaB) is a pleiotropic transcription factor that generally enhances cellular resistance to apoptotic cell death. It has been shown to be constitutively active in some cancers and is being pursued as potential anticancer ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad408ee84a7cef13dc4db70182f9846f
https://pubmed.ncbi.nlm.nih.gov/19457125
https://pubmed.ncbi.nlm.nih.gov/19457125
Malignant gliomas have been shown to release glutamate, which kills surrounding brain cells, creating room for tumor expansion. This glutamate release occurs primarily via system xC−, a Na+-independent cystine-glutamate exchanger. We show here, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c03219a3f74d8b772c1a156fd5052ab
https://europepmc.org/articles/PMC2045073/
https://europepmc.org/articles/PMC2045073/
Autor:
Lauren K. Dunn, Gregory A. Clines, Viktória Havasi, Michael S. Stalvey, Katrina L. Clines, Christopher R. McKibbin, W. Joon Chung
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 11, p e80098 (2013)
PLoS ONE, Vol 8, Iss 11, p e80098 (2013)
Low bone mass and increased fracture risk are recognized complications of cystic fibrosis (CF). CF-related bone disease (CFBD) is characterized by uncoupled bone turnover--impaired osteoblastic bone formation and enhanced osteoclastic bone resorption
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d255fb413cc7668fc75dc4ca8e1857
https://doi.org/10.1371/journal.pone.0080098
https://doi.org/10.1371/journal.pone.0080098