Výsledky vyhledávání - "W. Jonathan Ryves"

Use of a Penetratin-Linked Peptide in Dictyostelium

Autor: W. Jonathan Ryves, Adrian J. Harwood

Publikováno v: Molecular Biotechnology. 33:123-132

The plasma membrane is an effective barrier to most macromolecules and hydrophilic molecules. Remarkably, a class of positively charged cell-penetrating peptides (CPPs) has been discovered that can translocate themselves and associated cargoes into t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8674656f7ff0d1a6337a63a958f657
https://doi.org/10.1385/mb:33:2:123

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GSK-3 activity in neocortical cells is inhibited by lithium but not carbamazepine or valproic acid

Autor: Robin S.B. Williams, Emma Dalton, Adrian J. Harwood, W. Jonathan Ryves

Publikováno v: Bipolar Disorders. 7:260-265

Objectives: Lithium (Li+) has been suggested to target the enzyme glycogen synthase kinase 3 (GSK-3) as a mechanism of mood stabilization. Inhibition of GSK-3 by a second mood-stabilizer, valproic acid (VPA), has also been reported, but this effect i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb857add181432445120ac9565bc681
https://doi.org/10.1111/j.1399-5618.2005.00194.x

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Dd-Alix, a conserved endosome-associated protein, controls Dictyostelium development

Autor: W. Jonathan Ryves, Laurence Aubry, Michel Satre, Sara Mattei, Béatrice Blot, Rémy Sadoul, Adrian J. Harwood, Gérard Klein

Publikováno v: Developmental Biology
Developmental Biology, Elsevier, 2005, 279 (1), pp.99-113. ⟨10.1016/j.ydbio.2004.12.004⟩
Developmental Biology, 2005, 279 (1), pp.99-113. ⟨10.1016/j.ydbio.2004.12.004⟩

International audience; We have characterized the Dictyostelium homolog of the mammalian protein Alix. Dd-Alix is encoded by a single gene and is expressed during vegetative growth and multicellular development. We showed that the alx null strain fai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da68756b922c00e67d68b931ebc79b3
https://hal.archives-ouvertes.fr/hal-00376250

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The interaction of glycogen synthase kinase-3 (GSK-3) with the cell cycle

Autor: W Jonathan, Ryves, Adrian J, Harwood

Publikováno v: Progress in cell cycle research. 5

GSK-3 is a multifunctional protein kinase known to play a pivotal role in the regulation of metabolism, the cytoskeleton and gene expression. It also interacts with the cell cycle in a number of ways. GSK-3 forms part of both Wnt and Hh signalling pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4dbdd470148d7be9472008d78b40840d
https://pubmed.ncbi.nlm.nih.gov/14593744

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Semi-synthesis of C203H-resiniferatoxin

Autor: Phil C. Gordge, Patricia Darcy, W. Jonathan Ryves, N. M. Hassan, Fred J. Evans, A. Tudor Evans

Publikováno v: Phytotherapy Research. 8:362-364

There has recently been considerable interest concerning the biochemical and pharmacological mechanisms of action of resiniferatoxin (Rx). Rx is a daphnane diterpene ester, which is part of the phorbol ester family of diterpenes. We have synthesized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a3d738ef2f6babf1fdd94ce9abc37d6
https://doi.org/10.1002/ptr.2650080610

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Glycogen synthase kinase-3 inhibition by lithium and beryllium suggests the presence of two magnesium binding sites

Autor: Rana Dajani, Adrian J. Harwood, Laurence H. Pearl, W. Jonathan Ryves

Publikováno v: Biochemical and biophysical research communications. 290(3)

Lithium inhibits (Li(+)) glycogen synthase kinase-3 (GSK-3) by competition for magnesium (Mg(2+)), but not ATP or substrate. Here, we show that the group II metal ion beryllium (Be(2+)) is a potent inhibitor of GSK-3 and competes for both Mg(2+) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06dcab23e54ec0a132f87a8fb69fead
https://pubmed.ncbi.nlm.nih.gov/11798168

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The activation of the alpha isotype of protein kinase C by phorbol ester in Swiss 3T3 cells

Autor: W. Jonathan Ryves, Sarah. A. Roberts, Fred J. Evans

Publikováno v: Biochemical Society transactions. 25(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3330aa6b684764de2537e7e5cada807c
https://pubmed.ncbi.nlm.nih.gov/9056943

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Analysis and purification of phorbol esters using normal phase HPLC and photodiode-array detection

Autor: Saša M. Dimitrijevic, Mayadah B. Shehadeh, W. Jonathan Ryves, Ursula Humer, N. M. Hassan, Fred J. Evans

Publikováno v: Journal of pharmaceutical and biomedical analysis. 15(3)

For the first time a normal-phase HPLC method using photodiode-array detection is described for the analysis and purification of phorbol esters. The use of the method is demonstrated with examples of 10 different tigliane and daphnane esters (TPA, DO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66bbf8b8bd0b0cb1fb7c80752fc3e530
https://pubmed.ncbi.nlm.nih.gov/8951701

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HL-60 cell differentiation induced by phorbol- and 12-deoxyphorbol-esters

Autor: Saša M. Dimitrijevic, Fred J. Evans, W. Jonathan Ryves, Philip C. Gordge

Publikováno v: Carcinogenesis. 15(11)

The human promyelocytic leukaemia cell (HL-60) undergoes differentiation into a macrophage-like form when exposed to both tumour promoting- and non-promoting phorbol esters. We have investigated the effect of the two non-promoting phorbol esters, 12-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d27689a9a5cd6f5f06b1a326958e92
https://pubmed.ncbi.nlm.nih.gov/7955099

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