Zobrazeno 1 - 10 of 64 pro vyhledávání: '"W. Jonatha"'
1
Akademický článek
Structural Analysis of Mitochondria in Cardiomyocytes: Insights into Bioenergetics and Membrane Remodeling
Autor: Raquel A. Adams, Zheng Liu, Chongere Hsieh, Michael Marko, W. Jonathan Lederer, M. Saleet Jafri, Carmen Mannella
Publikováno v: Current Issues in Molecular Biology, Vol 45, Iss 7, Pp 6097-6115 (2023)
Mitochondria in mammalian cardiomyocytes display considerable structural heterogeneity, the significance of which is not currently understood. We use electron microscopic tomography to analyze a dataset of 68 mitochondrial subvolumes to look for corr
Externí odkaz: https://doaj.org/article/51a0dfc17d1845cb83dab02cb067b59f
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2
Akademický článek
Persistent foramen of Huschke: Presentation, evaluation, and management
Autor: Robert J. Macielak, Ashley M. Nassiri, W. Jonathan Fillmore, John I. Lane, Colin L. W. Driscoll, Matthew L. Carlson
Publikováno v: Laryngoscope Investigative Otolaryngology, Vol 7, Iss 1, Pp 237-241 (2022)
Abstract Objective Describe the presentation and management strategy for patients with symptomatic foramen of Huschke (FH). Patients Adults with persistent FH confirmed on imaging. Interventions Diagnosis and management of symptomatic persistent FH.
Externí odkaz: https://doaj.org/article/900fb7b4427f4891b0d7fd2b162a25a6
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3
Akademický článek
Recent Advances in Temporomandibular Joint Surgery
Autor: Catherine Wroclawski, Jai Kumar Mediratta, W. Jonathan Fillmore
Publikováno v: Medicina, Vol 59, Iss 8, p 1409 (2023)
Temporomandibular disorders (TMDs) affect a high percentage of children and adults worldwide. Surgery may be indicated in severe or recalcitrant cases. Several recent advancements in TMD and temporomandibular joint (TMJ) surgery have elevated underst
Externí odkaz: https://doaj.org/article/727a53cbdd734f26a22bf526508a21db
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4
Akademický článek
Effect of crista morphology on mitochondrial ATP output: A computational study
Autor: Nasrin Afzal, W. Jonathan Lederer, M. Saleet Jafri, Carmen A. Mannella
Publikováno v: Current Research in Physiology, Vol 4, Iss , Pp 163-176 (2021)
Folding of the mitochondrial inner membrane (IM) into cristae greatly increases the ATP-generating surface area, SIM, per unit volume but also creates diffusional bottlenecks that could limit reaction rates inside mitochondria. This study explores po
Externí odkaz: https://doaj.org/article/0d950773c2b040f1963c58c53b9e36bb
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5
Akademický článek
Attenuating persistent sodium current–induced atrial myopathy and fibrillation by preventing mitochondrial oxidative stress
Autor: Uma Mahesh R. Avula, Haikel Dridi, Bi-xing Chen, Qi Yuan, Alexander N. Katchman, Steven R. Reiken, Amar D. Desai, Samantha Parsons, Haajra Baksh, Elaine Ma, Parmanand Dasrat, Ruiping Ji, Yejun Lin, Christine Sison, W. Jonathan Lederer, Humberto C. Joca, Christopher W. Ward, Maura Greiser, Andrew R. Marks, Steven O. Marx, Elaine Y. Wan
Publikováno v: JCI Insight, Vol 6, Iss 23 (2021)
Mechanistically driven therapies for atrial fibrillation (AF), the most common cardiac arrhythmia, are urgently needed, the development of which requires improved understanding of the cellular signaling pathways that facilitate the structural and ele
Externí odkaz: https://doaj.org/article/b7be647bfebd45409f3562f2a31b359c
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6
Akademický článek
Understanding Calmodulin Variants Affecting Calcium-Dependent Inactivation of L-Type Calcium Channels through Whole-Cell Simulation of the Cardiac Ventricular Myocyte
Autor: Matthew D. McCoy, Aman Ullah, W. Jonathan Lederer, M. Saleet Jafri
Publikováno v: Biomolecules, Vol 13, Iss 1, p 72 (2022)
Mutations in the calcium-sensing protein calmodulin (CaM) have been linked to two cardiac arrhythmia diseases, Long QT Syndrome 14 (LQT14) and Catecholaminergic Polymorphic Ventricular Tachycardia Type 4 (CPVT4), with varying degrees of severity. Fun
Externí odkaz: https://doaj.org/article/ae2c54ff9bf54e888602cb1867c65c1b
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7
Akademický článek
Impact of an enhanced recovery pathway on length of stay and complications in elective radical cystectomy: a before and after cohort study
Autor: W. Jonathan Dunkman, Michael W. Manning, John Whittle, John Hunting, Edward N. Rampersaud, Brant A. Inman, Julie K. Thacker, Timothy E. Miller
Publikováno v: Perioperative Medicine, Vol 8, Iss 1, Pp 1-10 (2019)
Abstract Background Enhanced recovery after surgery (ERAS) pathways aim to standardize and integrate perioperative care, incorporating the best available evidence-based practice throughout the perioperative period targeted at attenuating the surgical
Externí odkaz: https://doaj.org/article/a2ffa89d58824fdb9f4ee7046a3e24d7
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8
Akademický článek
Understanding the Dynamics of the Transient and Permanent Opening Events of the Mitochondrial Permeability Transition Pore with a Novel Stochastic Model
Autor: Keertana Yalamanchili, Nasrin Afzal, Liron Boyman, Carmen A. Mannella, W. Jonathan Lederer, M. Saleet Jafri
Publikováno v: Membranes, Vol 12, Iss 5, p 494 (2022)
The mitochondrial permeability transition pore (mPTP) is a non-selective pore in the inner mitochondrial membrane (IMM) which causes depolarization when it opens under conditions of oxidative stress and high concentrations of Ca2+. In this study, a s
Externí odkaz: https://doaj.org/article/6b1e4df73dcb404b9f913922d3c64a1d
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