Zobrazeno 1 - 10
of 346
pro vyhledávání: '"W. Johannes"'
Autor:
Arun Chandramohan, Hubert Josien, Tsz Ying Yuen, Ruchia Duggal, Diana Spiegelberg, Lin Yan, Yu-Chi Angela Juang, Lan Ge, Pietro G. Aronica, Hung Yi Kristal Kaan, Yee Hwee Lim, Andrea Peier, Brad Sherborne, Jerome Hochman, Songnian Lin, Kaustav Biswas, Marika Nestor, Chandra S. Verma, David P. Lane, Tomi K. Sawyer, Robert Garbaccio, Brian Henry, Srinivasaraghavan Kannan, Christopher J. Brown, Charles W. Johannes, Anthony W. Partridge
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Although stapled α-helical peptides can address challenging targets, their advancement is impeded by poor understandings for making them cell permeable while avoiding off-target toxicities. By synthesizing >350 molecules, we present workflo
Externí odkaz:
https://doaj.org/article/244b34e3aef44b508696598d0927724f
Autor:
Stephen H. Kasper, Stephanie Otten, Brian Squadroni, Cionna Orr‐Terry, Yi Kuang, Lily Mussallem, Lan Ge, Lin Yan, Srinivasaraghavan Kannan, Chandra S. Verma, Christopher J. Brown, Charles W. Johannes, David P. Lane, Arun Chandramohan, Anthony W. Partridge, Lee R. Roberts, Hubert Josien, Alex G. Therien, Erik C. Hett, Bonnie J. Howell, Andrea Peier, Xi Ai, Jason Cassaday
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 5, Pp n/a-n/a (2023)
Abstract Cyclic peptides are poised to target historically difficult to drug intracellular protein–protein interactions, however, their general cell impermeability poses a challenge for characterizing function. Recent advances in microfluidics have
Externí odkaz:
https://doaj.org/article/4ede5586001347c2a4d447e4b2a014ec
Autor:
Fabian Hoffmann, Jérémy Rabineau, Dennis Mehrkens, Darius A. Gerlach, Stefan Moestl, Bernd W. Johannes, Enrico G. Caiani, Pierre Francois Migeotte, Jens Jordan, Jens Tank
Publikováno v:
ESC Heart Failure, Vol 8, Iss 1, Pp 729-744 (2021)
Abstract Aims Reduced physical activity increases the risk of heart failure; however, non‐invasive methodologies detecting subclinical changes in myocardial function are not available. We hypothesized that myocardial, left ventricular, systolic str
Externí odkaz:
https://doaj.org/article/1d74d02191cb49c6b24eec6845eef49e
Autor:
Adriana E. Tron, Matthew A. Belmonte, Ammar Adam, Brian M. Aquila, Lawrence H. Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J. Embrey, Eric Gangl, Francis D. Gibbons, Gareth P. Gregory, David Hargreaves, J. Adam Hendricks, Jeffrey W. Johannes, Ricky W. Johnstone, Steven L. Kazmirski, Jason G. Kettle, Michelle L. Lamb, Shannon M. Matulis, Ajay K. Nooka, Martin J. Packer, Bo Peng, Philip B. Rawlins, Daniel W. Robbins, Alwin G. Schuller, Nancy Su, Wenzhan Yang, Qing Ye, Xiaolan Zheng, J. Paul Secrist, Edwin A. Clark, David M. Wilson, Stephen E. Fawell, Alexander W. Hird
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
High expression of Mcl-1 promotes tumorigenesis and resistance to anticancer therapies. Here they report a macrocyclic molecule with high selectivity and affinity for Mcl-1 that exhibits potent anti-tumor effects as single agent and in combination wi
Externí odkaz:
https://doaj.org/article/814ff3ef6b204d84917e2b025f3e1da9
Autor:
D. Thean, J. S. Ebo, T. Luxton, Xue’Er Cheryl Lee, T. Y. Yuen, F. J. Ferrer, C. W. Johannes, D. P. Lane, C. J. Brown
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Linear peptides can mimic and disrupt protein-protein interactions involved in critical cell signaling pathways. Such peptides however are usually protease sensitive and unable to engage with intracellular targets due to lack of membrane per
Externí odkaz:
https://doaj.org/article/5cc897bcbc9a4ba18063d8ebc7a1fd3e
Autor:
Cameron H. Chrisman, Max Kudisch, Katherine O. Puffer, Trevor K. Stewart, Yisrael M. L. Lamb, Chern-Hooi Lim, Randolph Escobar, Pall Thordarson, Jeffrey W. Johannes, Garret M. Miyake
Publikováno v:
Journal of the American Chemical Society.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42d21e94dc9d9352b3a05bf52806e128
https://doi.org/10.1021/jacs.3c02784
https://doi.org/10.1021/jacs.3c02784
Autor:
David Hargreaves, Rodrigo J. Carbajo, Michael S. Bodnarchuk, Kevin Embrey, Philip B. Rawlins, Martin Packer, Sébastien L. Degorce, Alexander W. Hird, Jeffrey W. Johannes, Elisabetta Chiarparin, Markus Schade
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The structure-based design of small-molecule inhibitors targeting protein–protein interactions (PPIs) remains a huge challenge as the drug must bind typically wide and shallow protein sites. A PPI target of high interest for hematological cancer th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2bffac636430c22137888d848f374ca
https://doi.org/10.1073/pnas.2221967120
https://doi.org/10.1073/pnas.2221967120
Autor:
null Stephen H. Kasper, null Stephanie Otten, null Brian Squadroni, null Cionna Orr‐Terry, null Yi Kuang, null Lily Mussallem, null Lan Ge, null Lin Yan, null Srinivasaraghavan Kannan, null Chandra S. Verma, null Christopher J. Brown, null Charles W. Johannes, null David P. Lane, null Arun Chandramohan, null Anthony W. Partridge, null Lee R. Roberts, null Hubert Josien, null Alex G. Therien, null Erik C. Hett, null Bonnie J. Howell, null Andrea Peier, null Xi Ai, null Jason Cassaday
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90a3660365f9c9945a524ebfb3f98bc0
https://doi.org/10.1002/btm2.10542/v2/response1
https://doi.org/10.1002/btm2.10542/v2/response1
Autor:
Huawei Chen, Corinne Reimer, Stephen E. Fawell, Keith Mikule, Michael Zinda, Edward W. Tate, Paul D. Lyne, Jonathan R. Dry, Deborah Lawson, Michelle L. Lamb, Jeffrey W. Johannes, David A. Scott, Dan Widzowski, Michele Mayo, Ryan T. Howard, Nancy Su, Jiaquan Wu, Farzin Gharahdaghi, Wenxian Wang, Xin Wang, Jingwen Zhang, Philip Petteruti, Tony Cheung, Shaun E. Grosskurth, Zebin Wang
Supplemental Fig S1- S6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c14ee784e9ce30d950b54ed3d29144
https://doi.org/10.1158/0008-5472.22418555
https://doi.org/10.1158/0008-5472.22418555