Zobrazeno 1 - 10
of 32
pro vyhledávání: '"W. Jeffrey Howe"'
Autor:
Veerabahu Shanmugasundaram, Jürgen Bajorath, Ralph E. Christoffersen, James D. Petke, W. Jeffrey Howe, Mark A. Johnson, Dimitris K. Agrafiotis, Pil Lee, Leslie A. Kuhn, Jay T. Goodwin, M. Katharine Holloway, Thompson N. Doman, W. Patrick Walters, Suzanne Schreyer, José L. Medina-Franco, Karina Martinez-Mayorga, Linda L. Restifo
Publikováno v:
Journal of Computer-Aided Molecular Design. 36:623-638
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4fcd4233176dd82476c1a8cc7e31cb1
https://doi.org/10.1007/s10822-022-00473-2
https://doi.org/10.1007/s10822-022-00473-2
Autor:
Donald G. Truhlar, W. Jeffrey Howe, Anthony J. Hopfinger, Jeff Blaney, Richard E. Dammkoehler
Drug research and discovery are of critical importance in human health care. Computational approaches for drug lead discovery and optimization have proven successful in many recent research programs. These methods have grown in their effectiveness no
Autor:
R. R. Hinshaw, M.‐M. Horng, W. Jeffrey Howe, David J. Anderson, and Steve R. Turner, Chong Kt, Steve A. Mizsak, Jeanette Kay Morris, Paul K. Tomich, Strohbach Joseph Walter, Karen Rene Romines
Publikováno v:
Journal of Medicinal Chemistry. 39:4125-4130
Previously, 3-substituted cycloalkylpyranones, such as 2d, have proven to be effective inhibitors of HIV protease. In an initial series of 3-(1-phenylpropyl) derivatives with various cycloalkyl ring sizes, the cyclooctyl analog was the most potent. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a199dab51c8bcffc1c4be5a96313db5
https://doi.org/10.1021/jm960296c
https://doi.org/10.1021/jm960296c
Autor:
Suvit Thaisrivongs, Harvey I. Skulnick, Steve R. Turner, Joseph W. Strohbach, Ruben A. Tommasi, Paul D. Johnson, Paul A. Aristoff, Thomas M. Judge, Ronald B. Gammill, Jeanette K. Morris, Karen R. Romines, Robert A. Chrusciel, Roger R. Hinshaw, Kong-Teck Chong, W. Gary Tarpley, Susan M. Poppe, David E. Slade, Janet C. Lynn, Miao-Miao Horng, Paul K. Tomich, Eric P. Seest, Lester A. Dolak, W. Jeffrey Howe, Gina M. Howard, Francis J. Schwende, Lisa N. Toth, Guy E. Padbury, Grace J. Wilson, Lihua Shiou, Gail L. Zipp, Karen F. Wilkinson, Bob D. Rush, Mary J. Ruwart, Kenneth A. Koeplinger, Zhiyang Zhao, Serena Cole, Renee M. Zaya, Thomas J. Kakuk, Musiri N. Janakiraman, Keith D. Watenpaugh
Publikováno v:
Journal of Medicinal Chemistry. 39:4349-4353
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7de8a7ff5c653756fe8a0d71028a5b
https://doi.org/10.1021/jm960541s
https://doi.org/10.1021/jm960541s
Autor:
Thomas C. Pinkerton, William M. Westler, Jun Haginaka, Eldon L. Ulrich, W. Jeffrey. Howe, Tokiko Murashima, Joseph P. Comiskey, John L. Markley, William F. Walkenhorst
Publikováno v:
Analytical Chemistry. 67:2354-2367
Individual protein domains and two domains in combination were prepared by enzymatic and chemical cleavage of turkey ovomucoid followed by isolation and purification by size-exclusion and ion-exchange chromatography. Silica bonded-phase HPLC columns
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669fb31d0bec22a5c620bdb22b8583c7
https://doi.org/10.1021/ac00110a006
https://doi.org/10.1021/ac00110a006
Autor:
W. Jeffrey Howe, Joseph B. Moon
Publikováno v:
Tetrahedron Computer Methodology. 3:697-711
Computer-based lead finding algorithms which attempt to design, on a de novo basis, ligands that will complement a known receptor site cavity face some major problems in terms of a combinatorial design space and the synthesizability of the designed m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aee9951ca75eccdde5a6e8790c7615a1
https://doi.org/10.1016/0898-5529(90)90168-8
https://doi.org/10.1016/0898-5529(90)90168-8
Publikováno v:
Volume 3: Turbo Expo 2002, Parts A and B.
Numerical simulations and laboratory measurements are performed to study the flow field and heat transfer in a linear cascade of turbine vanes. The vanes are scaled-up versions of a turbine engine inlet vane but simplified in that they are untwisted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75e4bc6144cdf1971c0271e26c47fed3
https://doi.org/10.1115/gt2002-30189
https://doi.org/10.1115/gt2002-30189
Autor:
Linda J. Barrett, Alfredo G. Tomasselli, Satish K. Sharma, W. Jeffrey Howe, Robert L. Heinrikson, David B. Evans, I M Reardon, Jean L. Sarcich
A study has been made of the susceptibility of recombinant constructs of reverse transcriptase (RT) and ribonuclease H (RNase H) from human immunodeficiency virus type 1 (HIV-1) to digestion by the HIV-1 protease. At neutral pH, the protease attacks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d24a545bef62e38a1e3abd9bd9d0201
https://europepmc.org/articles/PMC2142316/
https://europepmc.org/articles/PMC2142316/
Autor:
W. Jeffrey Howe, Joseph B. Moon
Publikováno v:
Trends in QSAR and Molecular Modelling 92 ISBN: 9789072199133
Trends in QSAR and Molecular Modelling 92
Trends in QSAR and Molecular Modelling 92
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db33a7ec9aeadd92e68a1f445d0ae35d
https://doi.org/10.1007/978-94-011-1472-1_2
https://doi.org/10.1007/978-94-011-1472-1_2
Autor:
J. O. Hui, Jackson B. Hester, Mariusz Jaskolski, Alexander Wlodawer, Jessica Harris, Ben M. Dunn, Heinrich J. Schostarez, A G Tomasselli, Roger A. Poorman, Charles S. Craik, L. Liu, D J Staples, D. L. Decamp, Tomi K. Sawyer, W. Todd Lowther, Robert L. Heinrikson, Kathy O'connell, W. Jeffrey Howe, Joseph B. Moon, Clarck W. Smith
Publikováno v:
International journal of peptide and protein research. 40(3-4)
This report details the structure-activity relationships of the HIV gag substrate analog Val-Ser-Gln-Asn-Leu psi[CH(OH)CH2]Val-Ile-Val (U-85548E), an inhibitor exhibiting subnanomolar affinity towards HIV type-1 aspartic proteinase (HIV-1 PR). Our da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757c7347b30df4c98ae7d71825d66331
https://pubmed.ncbi.nlm.nih.gov/1478785
https://pubmed.ncbi.nlm.nih.gov/1478785