Zobrazeno 1 - 10
of 30
pro vyhledávání: '"W. James Cook"'
Autor:
Yina H. Huang, H. Robert Frost, Charles L. Sentman, Prathna Kumar, Jia Zou, Leena Abdullah, W. James Cook, Cameron M. Messier, Courtney T. Schiebout, Shannon L. Ferry, Rachel A. Brog
Chimeric-antigen receptor (CAR) T-cell therapy has shown remarkable efficacy against hematologic tumors. Yet, CAR T-cell therapy has had little success against solid tumors due to obstacles presented by the tumor microenvironment (TME) of these cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e763a90f7b7bca6c647e632a280595
https://doi.org/10.1158/2326-6066.c.6550805
https://doi.org/10.1158/2326-6066.c.6550805
Autor:
Rachel A. Brog, Shannon L. Ferry, Courtney T. Schiebout, Cameron M. Messier, W. James Cook, Leena Abdullah, Jia Zou, Prathna Kumar, Charles L. Sentman, H. Robert Frost, Yina H. Huang
Publikováno v:
Cancer Immunol Res
Chimeric-antigen receptor (CAR) T-cell therapy has shown remarkable efficacy against hematologic tumors. Yet, CAR T-cell therapy has had little success against solid tumors due to obstacles presented by the tumor microenvironment (TME) of these cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1d8c350cb983fe034831ca60d878ce
https://doi.org/10.1158/2326-6066.cir-21-0536
https://doi.org/10.1158/2326-6066.cir-21-0536
Publikováno v:
ImmunoHorizons. 4:597-607
The NKG2D ligand MHC class I chain–related protein A (MICA) is expressed on many varieties of malignant cells but is absent from most normal tissues, and thus represents a potential target for chimeric Ag receptor (CAR) T cell–based therapeutics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fe4f859b697a0d962149650f7ad29c
https://doi.org/10.4049/immunohorizons.2000041
https://doi.org/10.4049/immunohorizons.2000041
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with unclear etiology and few treatment options. Engineering of human cells for therapy has great potential to provide a means to create long-lived therapeutics that can r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bdef0ce027a4b40c38a8c6f3761ed2d
https://doi.org/10.1101/2021.09.27.461982
https://doi.org/10.1101/2021.09.27.461982
Autor:
Juergen H Nett, W James Cook, Ming-Tang Chen, Robert C Davidson, Piotr Bobrowicz, Warren Kett, Elena Brevnova, Thomas I Potgieter, Mark T Mellon, Bianka Prinz, Byung-Kwon Choi, Dongxing Zha, Irina Burnina, John T Bukowski, Min Du, Stefan Wildt, Stephen R Hamilton
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68325 (2013)
The methylotrophic yeast, Pichiapastoris, is an important organism used for the production of therapeutic proteins. However, the presence of fungal-like glycans, either N-linked or O-linked, can elicit an immune response or enable the expressed prote
Externí odkaz:
https://doaj.org/article/430da7bedc8648048bd5e05cd1244467
Autor:
Marie-Louise Sentman, Benjamin Demoulin, David E Gilham, Caroline Lonez, Sophie Agaugue, W. James Cook, Charles L Sentman, David J. Graber, Joana M. Murad
Publikováno v:
Future Oncology. 13:1593-1605
Chimeric antigen receptors (CARs) are genetically engineered proteins that combine an extracellular antigen-specific recognition domain with one or several intracellular T-cell signaling domains. When expressed in T cells, these CARs specifically tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb694966a9118c270f6707fe7684100d
https://doi.org/10.2217/fon-2017-0102
https://doi.org/10.2217/fon-2017-0102
Autor:
Juergen H. Nett, Terrance A. Stadheim, Huijuan Li, Min Du, Piotr Bobrowicz, Daniel Hopkins, Nathan J Sharkey, John Bukowski, W. James Cook, Sujatha Gomathinayagam, Irina Burnina, Stephen R. Hamilton, Shaina Schwartz, Stefan Wildt
Publikováno v:
Glycobiology. 23:1192-1203
The methylotrophic yeast, Pichia pastoris, is an important organism used for the production of therapeutic proteins. Previously, we have reported the glycoengineering of this organism to produce human-like N-linked glycans but up to now no one has ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef85cbf2997467f77dbc6ad086fca73c
https://doi.org/10.1093/glycob/cwt056
https://doi.org/10.1093/glycob/cwt056
Publikováno v:
Journal of Virology. 87:2058-2071
Myeloid-derived suppressor cells (MDSCs) have been characterized in several disease settings, especially in many tumor systems. Compared to their involvement in tumor microenvironments, however, MDSCs have been less well studied in their responses to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd42985497cb0b4977f0670179038551
https://doi.org/10.1128/jvi.01547-12
https://doi.org/10.1128/jvi.01547-12
Publikováno v:
Journal of Virology. 82:2456-2469
Pathology due to the immune system's response to viral infections often represents a delicate balance between inhibition of viral pathogenesis and regulation of protective immunity. In susceptible C57BL/6 (B6) mice, the murine retroviral isolate LP-B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67127ce6a3b3872ac76e645059120a97
https://doi.org/10.1128/jvi.01665-07
https://doi.org/10.1128/jvi.01665-07
Autor:
Ling-Li Lin, Li-Fan Lu, Cory L. Ahonen, Randolph J. Noelle, Vanitha S. Raman, W. James Cook, Evan F. Lind
Publikováno v:
Blood. 110:193-200
The recruitment of tumor necrosis factor receptor–associated factors (TRAFs) 1, 2, 3, 5, and 6 to the CD40 cytoplasmic tail upon CD40 trimerization results in downstream signaling events that ultimately lead to CD40-dependent, thymus-dependent (TD)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d9465643c466291c3111e2e696c8af
https://doi.org/10.1182/blood-2006-07-038414
https://doi.org/10.1182/blood-2006-07-038414