Zobrazeno 1 - 10
of 11
pro vyhledávání: '"W. J. Kinnier"'
Autor:
W. J. Kinnier, Christopher H. Price, Paul M. Sweetnam, Jean Lancaster, Lisa Caldwell, Barbara McMillan, Charles Bauer
Publikováno v:
Journal of Natural Products. 56:441-455
Radioligand receptor binding has been used extensively to identify and characterize a host of receptors and enzymes targeting virtually every therapeutic area. Many drug discovery programs have been based on the utilization of radioligand receptor bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689d41314bfef8c74de69c2b4845798e
https://doi.org/10.1021/np50094a001
https://doi.org/10.1021/np50094a001
Autor:
R E, Howell, K D, Laemont, M P, Kovalsky, V C, Lowe, P P, Waid, W J, Kinnier, L, Noronha-Blob
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 270(2)
The need for a smooth muscle-selective muscarinic antagonist that could provide oral bronchodilator activity with minimal side effects has led to the discovery of 3-(4-benzyl-piperazinyl)-1-cyclobutyl-1-hydroxy-1-phenyl-2-propanone (NPC-14695). Orall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ab9bbdcab7c7618809fabb53efa546fe
https://pubmed.ncbi.nlm.nih.gov/8071847
https://pubmed.ncbi.nlm.nih.gov/8071847
Autor:
A. T. Warner, R. N. Hiner, W. J. Kinnier, R. F. Gaudette, J. Perumattam, J. A. Schenden, R. E. Howell, M. C. Raynor, W. T. Muehsam
Publikováno v:
Purines in Cellular Signaling ISBN: 9781461279969
Theophylline has long been one of the most effective and frequently used drugs for the treatment of asthma. Recently another xanthine, enprofylline, has been found useful for the treatment of asthma (Pauwels, et al, 1985). Unfortunately, the mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c032a4da45ae02e0a3ec799a352f263
https://doi.org/10.1007/978-1-4612-3400-5_54
https://doi.org/10.1007/978-1-4612-3400-5_54
Autor:
McPherson Dw, Waclaw Janusz Rzeszotarski, L Noronha-Blob, W J Kinnier, J W Ferkany, A Kirkien-Rzeszotarski
Publikováno v:
Journal of medicinal chemistry. 31(7)
All of the optical isomers of the muscarinic antagonists 3-(1-azabicyclo[2.2.2]octyl) alpha-hydroxy-alpha,alpha-diphenylacetate (3-quinuclidinyl benzilate, QNB, 1) 3-(1-azabicyclo[2.2.2]octyl) xanthene-9-carboxylate (3-quinuclidinyl xanthene-9-carbox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb4e2efb295ffc5700953211a9b7ed5
https://pubmed.ncbi.nlm.nih.gov/3385735
https://pubmed.ncbi.nlm.nih.gov/3385735
Publikováno v:
Molecular pharmacology. 32(5)
Opiate, muscarinic, and alpha 2-adrenergic receptors on NCB-20 and NG108-15 neuroblastoma hybrid cells were up-regulated by treatment of the cells with media (CM) conditioned by previous incubation with either cell type. NG cells treated with CM from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb0769973148da82ae985658c4d473e9
https://pubmed.ncbi.nlm.nih.gov/2824982
https://pubmed.ncbi.nlm.nih.gov/2824982
Publikováno v:
Molecular pharmacology. 30(6)
Opiate, muscarinic, and alpha 2-adrenergic receptors and the Ni-coupled response of adenylate cyclase (AC) inhibition were examined in neuroblastoma X glioma NG108-15 (108 CC15) and neuroblastoma X Chinese hamster brain NCB-20 clonal hybrid cells, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::336b3b2206534c2ba5dce73ef7fef4ea
https://pubmed.ncbi.nlm.nih.gov/3023808
https://pubmed.ncbi.nlm.nih.gov/3023808
Publikováno v:
Molecular pharmacology. 18(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9b01e2111818f63f3dd9b360cf848e8
https://pubmed.ncbi.nlm.nih.gov/6258045
https://pubmed.ncbi.nlm.nih.gov/6258045
Autor:
D. N. Johnson, L. F. Sancilio, W. J. Kinnier, J. W. Ward, C. A. Leonard, W. N. Dannenburg, A G Proakis, R. S. Alphin, W. L. Smith
Publikováno v:
Digestive diseases and sciences. 31(5)
The antiemetic activity, gastric motor activity, and dopamine receptor effects of metoclopramide, dazopride, and sulpiride were assessed to establish if enhancement of gastric motility or antagonism of central dopamine receptors is the predominant ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24201e5afcded3a08d54f3eeb609e0ca
https://pubmed.ncbi.nlm.nih.gov/3698769
https://pubmed.ncbi.nlm.nih.gov/3698769
Publikováno v:
Life sciences. 39(12)
The PC12 cell line, a clone isolated from a pheochromocytoma tumor of rat adrenal medulla, was shown to exclusively contain stimulatory adenosine (A2) receptors linked to adenylate cyclase (AC). AC was stimulated 6-7 fold by several agonists with a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f6cb906f646c8fdebcefff88af992e
https://pubmed.ncbi.nlm.nih.gov/3018408
https://pubmed.ncbi.nlm.nih.gov/3018408
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 249(3)
The relationships between activation of muscarinic receptors in guinea pig bladder measured as carbachol-stimulated inositol phosphate (IP) accumulation, oxotremorine-induced adenylate cyclase (AC) inhibition and bladder detrusor smooth muscle contra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91dcb2d376da66b38e297b65f7888c45
https://pubmed.ncbi.nlm.nih.gov/2543813
https://pubmed.ncbi.nlm.nih.gov/2543813