Zobrazeno 1 - 9
of 9
pro vyhledávání: '"W. J. Hoekstra"'
Autor:
William R. Moore, Lisa Long, Edward P. Garvey, R. J. Schotzinger, W. J. Hoekstra, Mahmoud A. Ghannoum
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:1992-1997
Current therapies used to treat dermatophytoses such as onychomycosis are effective but display room for improvement in efficacy, safety, and convenience of dosing. We report here that the investigational agent VT-1161 displays potent in vitro antifu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494b738fac04e09c1d49176d82a201c8
https://doi.org/10.1128/aac.04902-14
https://doi.org/10.1128/aac.04902-14
Autor:
Wiley A. Schell, Edward P. Garvey, W. J. Hoekstra, A. M. Jones, R. J. Schotzinger, Barbara D. Alexander
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
The in vitro activities of fungal CYP51 inhibitors VT-1161 and VT-1129 were determined for Candida glabrata ( n = 34) and C. krusei ( n = 50). C. glabrata isolates were screened for FKS gene mutations. All isolates were resistant clinically and/or in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db7e971faa46259668792bf3e0a0de6
https://doi.org/10.1128/aac.01817-16
https://doi.org/10.1128/aac.01817-16
Autor:
Edward P. Garvey, William R. Moore, Andrew G. S. Warrilow, Claire M. Hull, R. J. Schotzinger, Diane E. Kelly, Josie E. Parker, Steven L. Kelly, W. J. Hoekstra
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:7121-7127
The binding and cytochrome P45051 (CYP51) inhibition properties of a novel antifungal compound, VT-1161, against purified recombinant Candida albicans CYP51 ( ERG11 ) and Homo sapiens CYP51 were compared with those of clotrimazole, fluconazole, itrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37debc3edb770aa203a8388040f5e68a
https://doi.org/10.1128/aac.03707-14
https://doi.org/10.1128/aac.03707-14
Autor:
R. J. Schotzinger, Elizabeth A. Lilly, Edward P. Garvey, W. J. Hoekstra, Jack D. Sobel, Paul L. Fidel
Publikováno v:
Antimicrobial agents and chemotherapy. 59(9)
Vulvovaginal candidiasis (VVC) and recurrent VVC (RVVC) remain major health problems for women. VT-1161, a novel fungal CYP51 inhibitor which has potent antifungal activity against fluconazole-sensitive Candida albicans , retained its in vitro potenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dad0d36c716c3c47ba3a242833cbdb9
https://pubmed.ncbi.nlm.nih.gov/26124165
https://pubmed.ncbi.nlm.nih.gov/26124165
Autor:
W. J. Hoekstra, B. L. Poulter
Publikováno v:
ChemInform. 29
The integrins are cell surface receptors that recognize extracellular matrix adhesive proteins such as fibrinogen, fibronectin, vitronectin, and VCAM-1 (vascular cell adhesion molecule-1). Nonpeptide integrin antagonists designed after the adhesion r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::466d05a874307bb90af33ca697ddbdee
https://doi.org/10.1002/chin.199834317
https://doi.org/10.1002/chin.199834317
Autor:
D. F. Maccomsey, Bruce E. Maryanoff, W. J. Hoekstra, J. A. Kauffman, M. F. Addo, R. M. Scarborough, B. L. Hulshizer, P. Andrade‐Gordon, D. Oksenberg
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baff5dc24abe0737b04eed24ba3dd7dc
https://doi.org/10.1002/chin.199844192
https://doi.org/10.1002/chin.199844192
Autor:
J T, Elliott, W J, Hoekstra, C K, Derian, M F, Addo, B E, Maryanoff, D G, Ahern, G D, Prestwich
Publikováno v:
The journal of peptide research : official journal of the American Peptide Society. 57(6)
Six photoactivatable analogs of the human thrombin receptor activating peptide (TRAP), SFLLRN-NH2, were synthesized by substituting the photoactive amino acid, p-benzoylphenylalanine (Bpa), into each position of the peptide sequence. Platelet aggrega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29f1177a725f0ef58f3a873d8afc2862
https://pubmed.ncbi.nlm.nih.gov/11437953
https://pubmed.ncbi.nlm.nih.gov/11437953
Autor:
W J, Hoekstra, B L, Poulter
Publikováno v:
Current medicinal chemistry. 5(3)
The integrins are cell surface receptors that recognize extracellular matrix adhesive proteins such as fibrinogen, fibronectin, vitronectin, and VCAM-1 (vascular cell adhesion molecule-1). Nonpeptide integrin antagonists designed after the adhesion r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25281642098e22480ed88895fc3c8719
https://pubmed.ncbi.nlm.nih.gov/9562602
https://pubmed.ncbi.nlm.nih.gov/9562602
Autor:
P F, Mulders, W J, Hoekstra, R P, Heybroek, E R, Schapers, A L, Verbeek, G O, Oosterhof, F M, Debruyne
Publikováno v:
European journal of cancer (Oxford, England : 1990). (7)
Patients with T1G3 bladder cancer have a considerable risk for recurrence and/or progressive disease. Until now no consensus has been achieved on the optimal treatment. Within the Dutch South Eastern Bladder Cancer Study Group, 155 patients with a T1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47e680968cf6ccfdf536eb7572cf5e83
https://pubmed.ncbi.nlm.nih.gov/7946577
https://pubmed.ncbi.nlm.nih.gov/7946577