Zobrazeno 1 - 10
of 95
pro vyhledávání: '"W. I. Rosenblum"'
Autor:
W. I. Rosenblum
Publikováno v:
Acta Physiologica. 224:e13111
Endothelium-dependent responses were first demonstrated 40 years ago in the aorta. Since then, extensive research has been conducted in vitro using conductance vessels and materials derived from them. However, the microcirculation controls blood flow
Publikováno v:
Stroke. 31:1153-1161
Background and Purpose —Leukocytes contribute to cerebral ischemia-reperfusion injury. However, few experimental models examine both in vivo behavior of leukocytes and microvascular rheology after stroke. The purpose of the present study was to cha
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 268:H512-H515
A laser-dye technique is known to injure selectively microvascular endothelium in situ. With the use of the arterioles on the surface of the mouse brain (pial arterioles), the endothelial injury is manifest by loss of several endothelium-dependent re
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 264:H665-H669
Pial arterioles of mice were monitored by intravital television microscopy. Responses to acetylcholine (ACh) and to McN-A-343, a selective M1 activator, were monitored before and after endothelial injury by a laser-dye technique in the presence or ab
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 262:H1343-H1349
As previously reported, NG-monomethyl-L-arginine (L-NMMA) constricted pial arterioles, inhibited dilation of pial arterioles by acetylcholine (ACh) or L-arginine (L-Arg), and enhanced platelet adhesion/aggregation at sites of endothelial damage. Howe
L-arginine suffusion restores response to acetylcholine in brain arterioles with damaged endothelium
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 262:H961-H964
Minor endothelial injury was produced in pial arterioles by a laser-Evans blue technique. This technique previously has been shown to prevent relaxation of the arterioles by topical acetylcholine (ACh) or bradykinin, agonists whose actions are known
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 261:H15-H21
In the presence of circulating Evans blue a helium-neon laser injures the endothelium of brain surface arterioles in situ. The injury is known to selectively eliminate endothelium-dependent responses. The present study documents in mice the fact that
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 259:H1396-H1401
Pial arterioles on the surface of the mouse brain were observed via television microscopy and measured with an image-splitting technique. The vessels were dilated by L-arginine (L-Arg) in concentrations as low as 10(-5) M and were constricted in dose
Autor:
W I, Rosenblum
Publikováno v:
Microcirculation (New York, N.Y. : 1994). 5(2-3)
To review the published data concerning the vasomotor responses of arterioles on the surface of the mouse brain. This information is essential to the planning of studies using genetically manipulated mice to investigate the control of cerebral vascul
Autor:
W I, Rosenblum
Publikováno v:
Clinical laboratory management review : official publication of the Clinical Laboratory Management Association. 12(4)
For two millennia, more or less, doctors all over the world have taken the Hippocratic oath to "do no harm." However, these words often have conflicted with social policy. Particularly in this century, some governments and other institutions have enc