Zobrazeno 1 - 10
of 45
pro vyhledávání: '"W. Hepworth"'
Autor:
Jennifer L. Reedy, Kirstine Nolling Jensen, Arianne J. Crossen, Kyle J. Basham, Rebecca A. Ward, Christopher M. Reardon, Hannah Brown Harding, Olivia W. Hepworth, Patricia Simaku, Geneva N. Kwaku, Kazuya Tone, Janet A. Willment, Delyth M. Reid, Mark H. T. Stappers, Gordon D. Brown, Jayaraj Rajagopal, Jatin M. Vyas
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Respiratory infections caused by the human fungal pathogen Aspergillus fumigatus are a major cause of mortality for immunocompromised patients. Exposure to these pathogens occurs through inhalation, although the role of the respiratory epith
Externí odkaz:
https://doaj.org/article/e6887f3ec8884f338db33021a03541eb
Autor:
Don N. Wickramasinghe, Claire M. Lyon, Sejeong Lee, Olivia W. Hepworth, Emily L. Priest, Corinne Maufrais, Adam P. Ryan, Emmanuelle Permal, Derek Sullivan, Brenda A. McManus, Bernhard Hube, Geraldine Butler, Christophe d'Enfert, Julian R. Naglik, Jonathan P. Richardson
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Candida albicans causes millions of mucosal infections in humans annually. Hyphal overgrowth on mucosal surfaces is frequently associated with tissue damage caused by candidalysin, a secreted peptide toxin that destabilizes the plasma membra
Externí odkaz:
https://doaj.org/article/3903d3d7c6d0456c8be1eb3b6dc95bad
Autor:
Jonathan P. Richardson, Rhys Brown, Nessim Kichik, Sejeong Lee, Emily Priest, Selene Mogavero, Corinne Maufrais, Don N. Wickramasinghe, Antzela Tsavou, Natalia K. Kotowicz, Olivia W. Hepworth, Ana Gallego-Cortés, Nicole O. Ponde, Jemima Ho, David L. Moyes, Duncan Wilson, Christophe D’Enfert, Bernhard Hube, Julian R. Naglik
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Candidalysin is the first cytolytic peptide toxin identified in any human fungal pathogen. Candidalysin is secreted by Candida albicans and is critical for driving infection and host immune responses in several model systems. However, Candid
Externí odkaz:
https://doaj.org/article/7a4e9cd34a2f4184b02a7bf66ce31248
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2542
In 2016, the first peptide toxin in any human fungal pathogen was identified. It was discovered in Candida albicans and was named candidalysin. Candidalysin is an amphipathic cationic peptide that damages cell membranes. Like most lytic peptides, can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::acea786833cb9fe571b02245fc74ae53
https://pubmed.ncbi.nlm.nih.gov/36008664
https://pubmed.ncbi.nlm.nih.gov/36008664
Autor:
Nicole O. Ponde, Léa Lortal, Antzela Tsavou, Olivia W. Hepworth, Don N. Wickramasinghe, Jemima Ho, Jonathan P. Richardson, David L. Moyes, Sarah L. Gaffen, Julian R. Naglik
Publikováno v:
The Journal of biological chemistry. 298(10)
Candida albicans (C. albicans) is a dimorphic commensal human fungal pathogen that can cause severe oropharyngeal candidiasis (oral thrush) in susceptible hosts. During invasive infection, C. albicans hyphae invade oral epithelial cells (OECs) and se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65fcca9d7711d5dfc2038b5fb333902
https://pubmed.ncbi.nlm.nih.gov/36037968
https://pubmed.ncbi.nlm.nih.gov/36037968
Autor:
Nicole O. Ponde, Léa Lortal, Antzela Tsavou, Olivia W. Hepworth, Don N. Wickramansinghe, Jemima Ho, Jonathan P. Richardson, David L. Moyes, Sarah L. Gaffen, Julian R. Naglik
Candida albicans (C. albicans) is a dimorphic human fungal pathogen that can cause severe oropharyngeal candidiasis (OPC, oral thrush) in susceptible hosts. During invasive infection, C. albicans hyphae invade oral epithelial cells (OECs) and secrete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6344f98ee983c958dead373959e781e2
https://doi.org/10.1101/2022.03.05.483111
https://doi.org/10.1101/2022.03.05.483111
Autor:
Nicole O. Ponde, Ruth E Dickenson, Spyridoula Angeliki Nikou, J. Ho, Jonathan P. Richardson, Julian R. Naglik, Olivia W. Hepworth
Publikováno v:
Methods in Molecular Biology ISBN: 9781071611814
The epithelial cell is usually the first host cell that interacts with the microbiota present at mucosal surfaces. Although initially thought of as "bystander" cells with barrier function, the epithelial cell is now known to be a sentinel cell in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40b94650b9d772f351ab9b562055b540
https://doi.org/10.1007/978-1-0716-1182-1_5
https://doi.org/10.1007/978-1-0716-1182-1_5
Autor:
David L. Moyes, Julian R. Naglik, Jonathan P. Richardson, Sarah L. Gaffen, Diksha Sihra, J. Ho, Bianca M. Coleman, Felix E. Y. Aggor, Martin Stacey, Akash H. Verma, Olivia W. Hepworth, Joseph S. Ainscough, Bernhard Hube, Hanna Zafar, Nicole O. Ponde, Mandy J. McGeachy
Publikováno v:
The Journal of Immunology. 201:627-634
Protection against microbial infection by the induction of inflammation is a key function of the IL-1 superfamily, including both classical IL-1 and the new IL-36 cytokine families. Candida albicans is a frequent human fungal pathogen causing mucosal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc603b7924ac49b30ff80c5cd138fd83
https://doi.org/10.4049/jimmunol.1800515
https://doi.org/10.4049/jimmunol.1800515
Autor:
Dixon, W. Hepworth
Publikováno v:
Advocate of Peace (1847-1884), 1875 Aug 01. 6(8/9), 49-49.
Externí odkaz:
https://www.jstor.org/stable/27905918
Autor:
Campbell M. W. Hepworth
Publikováno v:
Quarterly Journal of the Royal Meteorological Society. 9:118-124
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cc3c0a28a6da4bb42a6bd09619492fd
https://doi.org/10.1002/qj.4970094613
https://doi.org/10.1002/qj.4970094613