Zobrazeno 1 - 10
of 403
pro vyhledávání: '"W. Harkness"'
Autor:
Arun Parupudi, Sumit K. Chaturvedi, Regina Adão, Robert W. Harkness, Sonia Dragulin-Otto, Lewis E. Kay, Reza Esfandiary, Huaying Zhao, Peter Schuck
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Weak macromolecular interactions assume a dominant role in the behavior of highly concentrated solutions, and are at the center of a variety of fields ranging from colloidal chemistry to cell biology, neurodegenerative diseases, and manufact
Externí odkaz:
https://doaj.org/article/e909457b3b7a460aaae039df639e78fb
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Complex assembly pathways often involve transient, partly-formed intermediates that are challenging to characterize. Here, the authors present a simple and rapid spectroscopic thermal hysteresis method for mapping the energy landscapes of supramolecu
Externí odkaz:
https://doaj.org/article/69a96f65f7364d2ebdc35ca9920a4ee7
Autor:
Tae Hun Kim, Michael L. Nosella, Nicolas Bolik-Coulon, Robert W. Harkness, Shuya Kate Huang, Lewis E. Kay
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Epigenetic modifications of chromatin play a critical role in regulating the fidelity of the genetic code and in controlling the translation of genetic information into the protein components of the cell. One key posttranslational modification is ace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b762aa1c4dc9822749594faa42076058
https://doi.org/10.1073/pnas.2301063120
https://doi.org/10.1073/pnas.2301063120
Autor:
Nicolas Bolik-Coulon, Alexander I.M. Sever, Robert W. Harkness, James M. Aramini, Yuki Toyama, D. Flemming Hansen, Lewis E. Kay
Publikováno v:
Journal of magnetic resonance (San Diego, Calif. : 1997). 346
The HMQC pulse sequence and variants thereof have been exploited in studies of high molecular weight protein complexes, taking advantage of the fact that fast and slow relaxing magnetization components are sequestered along two distinct magnetization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39e0f462abd113fc8392dd0a7051d6d
https://pubmed.ncbi.nlm.nih.gov/36508761
https://pubmed.ncbi.nlm.nih.gov/36508761
Flexible client-dependent cages in the assembly landscape of the periplasmic protease-chaperone DegP
The periplasmic protein DegP, that is implicated in virulence factor transport leading to pathogenicity, is a bi-functional protease and chaperone that maintains protein homeostasis in gram-negative bacteria. To perform these functions, DegP captures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd36d32446f3fd55d3e1d68f7c027b7b
https://doi.org/10.1101/2022.10.17.512556
https://doi.org/10.1101/2022.10.17.512556
Autor:
Huaying Zhao, Lewis E. Kay, Robert W. Harkness, Reza Esfandiary, Sonia Dragulin-Otto, Regina C. Adão, Arun Parupudi, Sumit Kumar Chaturvedi, Peter Schuck
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Weak macromolecular interactions assume a dominant role in the behavior of highly concentrated solutions, and are at the center of a variety of fields ranging from colloidal chemistry to cell biology, neurodegenerative diseases, and manufacturing of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3475d0ae60245de4102decede987b00e
https://doaj.org/article/e909457b3b7a460aaae039df639e78fb
https://doaj.org/article/e909457b3b7a460aaae039df639e78fb
Akademický článek
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Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(17)
The human high-temperature requirement A2 (HtrA2) protein is a trimeric protease that cleaves misfolded proteins to protect cells from stresses caused by toxic, proteinaceous aggregates, and the aberrant function of HtrA2 is closely related to the on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860b3843b48cac3b9adfa525a76c3c21
https://pubmed.ncbi.nlm.nih.gov/35452308
https://pubmed.ncbi.nlm.nih.gov/35452308
Publikováno v:
Proc Natl Acad Sci U S A
The human high-temperature requirement A2 (HtrA2) mitochondrial protease is critical for cellular proteostasis, with mutations in this enzyme closely associated with the onset of neurodegenerative disorders. HtrA2 forms a homotrimeric structure, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2466d8291eb4e6874d684839e04cfeda
https://pubmed.ncbi.nlm.nih.gov/34446566
https://pubmed.ncbi.nlm.nih.gov/34446566
Autor:
Huaying Zhao, Yuki Toyama, Zev A Ripstein, Jacob P. Brady, Peter Schuck, Patricia L. Clark, Lewis E. Kay, Robert W. Harkness, Alexander I M Sever, Qing Luan
Publikováno v:
Proc Natl Acad Sci U S A
DegP is an oligomeric protein with dual protease and chaperone activity that regulates protein homeostasis and virulence factor trafficking in the periplasm of gram-negative bacteria. A number of oligomeric architectures adopted by DegP are thought t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773669c114bba7fc5295cdfde7633f57
https://doi.org/10.1073/pnas.2109732118
https://doi.org/10.1073/pnas.2109732118