Zobrazeno 1 - 10
of 18
pro vyhledávání: '"W. H. Soine"'
Publikováno v:
ChemInform. 24
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 30(12)
(+)- and (-)-Chloroephedrine, and their respective aziridines, cis- and trans-1,2-dimethyl-3-phenylaziridine, have been reported present in clandestinely synthesized methamphetamine. Since methamphetamine and structurally related compounds are potent
Publikováno v:
Convulsive therapy. 12(3)
Autor:
S M, Neighbors, W H, Soine
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(5)
Mice were evaluated for their ability to form phenobarbital N-glucuronides. Following oral administration of [14C]phenobarbital to mice, a radiolabeled phenobarbital metabolite cochromatographed with synthetic standards of phenobarbital N-glucuronide
Publikováno v:
Pharmaceutical research. 11(11)
A study was undertaken to determine if humans excreted pentobarbital N-glucosides as urinary metabolites following oral administration of pentobarbital. (1'RS,5RS)-1-(beta-D-Glucopyranosyl)pentobarbital ((1'RS,5RS)-PTBG) was isolated from the urine o
Publikováno v:
Pharmaceutical research. 9(5)
A method is described for the assay of phenobarbital N-glucosylation using UDP-D-[6-3H]glucose. The radioactive phenobarbital N-glucoside conjugates [(5R)-PBG, (5S)-PBG] formed during the incubations were resolved from each other and from uncharacter
Publikováno v:
Journal of forensic sciences. 37(2)
Common analytical methods used for identifying samples obtained from clandestine laboratories were evaluated for their ability to differentiate between possible amphetamine isomers and homologs. A series of ring-substituted (4-methyl, 4-methoxy, and
Autor:
S E, Mongrain, W H, Soine
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 19(5)
Publikováno v:
Pharmaceutical research. 7(8)
The stereochemistry associated with the amobarbital N-glucoside diastereomers (1a and 1b) that are excreted by humans in urine is unknown. Using X-ray crystallography, the absolute configuration of 1b was determined to be S (C-5 position of the barbi
Publikováno v:
Pharmaceutical research. 7(4)
The absolute configuration of the N-beta-D-glucoside metabolites of phenobarbital was determined by methylation of the diastereomers to make mephobarbital N-beta-D-glucosides, followed by oxidative removal of glucose to give the optical isomers of me