Zobrazeno 1 - 10
of 20
pro vyhledávání: '"W. H. Roark"'
Autor:
Helen T. Lee, Brian R. Krause, Bruce D. Roth, R. L. Stanfield, W. H. Roark, Joseph Armand Picard, Drago Robert Sliskovic, R. F. Bousley, K. L. Hamelehle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:289-294
Sulfoacetic acid, phosphoramidate, and phosphoramide analogs of the ACAT inhibitors, CI-999 and CI-1011 were synthesized. The structure-activity relationships of these compounds as ACAT inhibitors are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74ac58e97453c222e55e48824453b5e
https://doi.org/10.1016/s0960-894x(98)00011-0
https://doi.org/10.1016/s0960-894x(98)00011-0
Autor:
Drago Sliskovic, Essenburg Ad, Joseph Armand Picard, J. F. Reindel, L. L. Minton, B.R. Krause, R. L. Stanfield, W. H. Roark
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:713-718
The synthesis and structure-activity relationships of a series of malonester amide ACAT inhibitors are described. One of these compounds, 4s , was shown to be a potent inhibitor of both the intestinal and arterial enzymes, bioactive upon oral dosing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91f0d88d43a22709606ea47b4b323690
https://doi.org/10.1016/0960-894x(96)00098-4
https://doi.org/10.1016/0960-894x(96)00098-4
Autor:
T. L. Stoeber, R. L. Stanfield, W. H. Roark, Brian R. Krause, C. J. Blankley, Bharat K. Trivedi, J. A. Picard, Ann Holmes, Essenburg Ad, M. K. Shaw
Publikováno v:
Journal of Medicinal Chemistry. 36:3300-3307
We have synthesized a series of N-phenyl-N'-aralkyl and N-phenyl-N'-(1-phenylcycloalkyl)ureas as inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). This intracellular enzyme is thought to be responsible for the esterification of dietary chole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb799f26eb61cb17cd1f2baa218096d7
https://doi.org/10.1021/jm00074a011
https://doi.org/10.1021/jm00074a011
Autor:
E. Ferguson, Roger S. Newton, J. A. Picard, C. S. Sekerke, D. R. Sliskovic, Bruce D. Roth, M. K. Shaw, W. H. Roark, Brian R. Krause
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ce7f75795111e57170fd2d2608cc986
https://doi.org/10.1002/chin.199124162
https://doi.org/10.1002/chin.199124162
Autor:
A. D. Essenburg, Brian R. Krause, Bharat K. Trivedi, R. L. Stanfield, M. K. Shaw, T. L. Stoeber, W. H. Roark, Joseph Armand Picard, C. J. Blankley, Ann Holmes
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08e94cd041b76b4d68bdf1a3f7313d6e
https://doi.org/10.1002/chin.199411118
https://doi.org/10.1002/chin.199411118
Autor:
Brian R. Krause, W. H. Roark, Bruce D. Roth, R. L. Stanfield, Reynold Homan, J. A. Picard, K. L. Hamelehle, Maureen K. Anderson, R. F. Bousley
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::231ce1fd4434c462c6f209d5a340cde7
https://doi.org/10.1002/chin.199608100
https://doi.org/10.1002/chin.199608100
Autor:
Brian R. Krause, Bruce D. Roth, R. L. Stanfield, R. F. Bousley, K. L. Hamelehle, Helen T. Lee, W. H. Roark, Joseph Armand Picard, Drago Robert Sliskovic
Publikováno v:
ChemInform. 29
Sulfoacetic acid, phosphoramidate, and phosphonamide analogs of the ACAT inhibitors, CI-999 and CI-1011 were synthesized. The structure-activity relationships of these compounds as ACAT inhibitors are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db8017ddc3605a10c99d165e14987673
https://doi.org/10.1002/chin.199824211
https://doi.org/10.1002/chin.199824211
Autor:
Ann Holmes, Bruce D. Roth, C. J. Blankley, Essenburg Ad, K.A. Kieft, W. H. Roark, R. L. Stanfield, Bharat K. Trivedi, Brian R. Krause, Milton L. Hoefle
Publikováno v:
Journal of Medicinal Chemistry. 35:1609-1617
A series of fatty acid anilides was prepared, and compounds were tested for their ability to inhibit the enzyme acyl-CoA:cholesterol acyltransferase (ACAT) in vitro and to lower plasma total cholesterol and elevate high-density lipoprotein cholestero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e850c63582d3658c596051af28b574
https://doi.org/10.1021/jm00087a016
https://doi.org/10.1021/jm00087a016
Autor:
J. A. Picard, M. K. Shaw, W. H. Roark, R. L. Stanfield, Roger S. Newton, Bruce David Roth, Drago Robert Sliskovic, B.R. Krause, C. J. Blankley, Catherine Sekerke
Publikováno v:
Journal of Medicinal Chemistry. 35:2095-2103
A series of N-heteroaryl-substituted mevalonolactones were prepared and evaluated for their ability to inhibit the enzyme HMG-CoA reductase both in vitro and in vivo, and to lower plasma cholesterol in a hypercholesterolemic dog model. The goal of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784c728a4e16e26340cd4acc97d28b05
https://doi.org/10.1021/jm00089a022
https://doi.org/10.1021/jm00089a022
Autor:
A M, Doherty, J S, Kaltenbronn, J P, Hudspeth, J T, Repine, W H, Roark, I, Sircar, F J, Tinney, C J, Connolly, J C, Hodges, M D, Taylor
Publikováno v:
Journal of Medicinal Chemistry. 34:1258-1271
A series of renin inhibitors with novel modifications at the P 2 site has been prepared. Structure-activity relationships reveal that for a particular P 2 fragment the in vitro potency is highly dependent on the nature of the P 2 ' portion in additio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6042b7e4ef3df80b4073efe2f2d2de6e
https://doi.org/10.1021/jm00108a004
https://doi.org/10.1021/jm00108a004