Zobrazeno 1 - 10
of 85
pro vyhledávání: '"W. H. Prusoff"'
Publikováno v:
Biochemical Pharmacology. 44:947-953
The poly ADP-ribosylation of proteins catalyzed by poly(ADP-ribose)polymerase (PARP) is involved in a number of important cellular metabolic activities. We evaluated various analogs of deoxythymidine and deoxyuridine as inhibitors of PARP. Most of th
Publikováno v:
Cancer research. 51(6)
The coadministration of thymidine (dThd) with either 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) or 3'-[3-(2-chloroethyl)-3-nitrosoureido]-3'-deoxythymidine (3'-CTNU) to L1210-bearing mice significantly enhanced the antitumor activity of both nitroso
Publikováno v:
Molecular pharmacology. 39(2)
3'-Deoxythymidin-2'-ene (d4T) is a potent and selective inhibitor of human immunodeficiency virus replication in a variety of human cell types and is currently undergoing phase I clinical trials for the treatment of acquired immunodeficiency syndrome
Publikováno v:
Journal of Biological Chemistry. 254:10747-10753
Publikováno v:
Journal of Biological Chemistry. 251:4833-4838
5-Iodo-5'-amino-2',5'-dideoxyuridine (AIdUrd) is a novel thymidine analog which inhibits herpes simplex virus, type 1 (HS-1 virus) replication in the absence of detectable host toxicity. When murine, simian, or human cells in culture are treated with
Publikováno v:
Journal of Virology. 30:942-945
Pyrimidine deoxyribonucleoside kinase (thymidine kinase [TK]) was purified from two herpes simplex virus type 1 (HVS-1)-transformed TK-deficient mouse (LMTK-) cell lines and from LMTK- cells infected with HSV-1 mutant viruses coding for variant TK en
Publikováno v:
Journal of Biological Chemistry. 251:4839-4842
5-Iodo-5'-amino-2',5'-dideoxyuridine-5'-N'-triphosphate (AIdUTP), a phosphoramidate analog of 5-iodo-2',5'-dideoxyuridine 5'-triphosphate (IdUTP), was synthesized and some of its chemical and biological properties were investigated. Although AIdUTP i
Autor:
M S Chen, W H Prusoff
Publikováno v:
Journal of Biological Chemistry. 254:10449-10452
Herpes simplex virus type 1 (HSV-1) encoded thymidine kinase converts 5-iodo-5'-amino-2',5'-dideoxyuridine (AIdUrd), a highly specific anti-herpes agent, into the 5'-diphosphate (AIdUDP) derivative in vitro. AIdUDP was identified by its acid lability
Autor:
R F, Schinazi, W H, Prusoff
Publikováno v:
Pediatric Clinics of North America. 30:77-92
Publikováno v:
Blood. 8:491-501
Fractionation of desiccated defatted hog stomach through the use of isoelectric and ammonium sulfate precipitation technics, and guided by assays in patients with pernicious anemia in relapse given daily oral doses of 5 µg. of vitamin B12, has led t