Zobrazeno 1 - 10 of 17 pro vyhledávání: '"W. H. Gerwick"'
2
Application of the BIRD sandwich for the rapid and accurate determination of (1)H-(1)H NMR coupling constants in higher order spin systems
Autor: R T, Williamson, J R, Carney, W H, Gerwick
Publikováno v: Journal of natural products. 63(6)
A method is presented that allows for the convenient and reliable determination of (1)H-(1)H NMR coupling constants in higher order or symmetrically coupled spin systems. The method can be applied on any programmable FT-NMR spectrometer and is demons
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::32f44d00016b5f5717bd3d0fc18f18b5
https://pubmed.ncbi.nlm.nih.gov/10869227
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3
Biogenesis and biological function of marine algal oxylipins
Autor: W H, Gerwick, M A, Roberts, A, Vulpanovici, D L, Ballantine
Publikováno v: Advances in experimental medicine and biology. 447
The biogenetic source of most marine algal oxylipins, which are many and of diverse structure, can logically be unified through a common lipoxygenase-derived hydroperoxide to epoxy allylic carbocation transformation. The biological role of oxylipins
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3388008ac8fd8c2b129aa003bb9af42
https://pubmed.ncbi.nlm.nih.gov/10086197
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5
Characterization of the interaction of the marine cyanobacterial natural product curacin A with the colchicine site of tubulin and initial structure-activity studies with analogues
Autor: A V, Blokhin, H D, Yoo, R S, Geralds, D G, Nagle, W H, Gerwick, E, Hamel
Publikováno v: Molecular pharmacology. 48(3)
Curacin A, the major lipid constituent of a strain of the marine cyanobacterium Lyngbya majuscula obtained off the coast of Curaçao, is a potent antimitotic agent that we have previously shown to inhibit microtubule assembly and colchicine binding t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e49cac3b0a5fd57caad467131e2344e
https://pubmed.ncbi.nlm.nih.gov/7565634
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6
Screening for Anticancer Leads from Marine Organisms in a Mechanism-Based Drug Discovery Program
Autor: P. Cannon, F. J. Schmitz, D. L. Slate, P. Crews, R. C. Schatzman, L. M. Hunter, W. H. Gerwick, B. Strulovici
Publikováno v: Anticancer Drug Discovery and Development: Natural Products and New Molecular Models ISBN: 9781461361183
Current estimates of the American Cancer Society are that during 1992 some 1.1 million Americans will have been diagnosed as having cancer. Additionally, over 500,000 people succumb annually to this disease. At the top of the list of fatal cancers (d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::689579a771ebb27d205b2f2ac63e6f56
https://doi.org/10.1007/978-1-4615-2610-0_17
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8
Discovery of the mammalian insulin release modulator, hepoxilin B3, from the tropical red algae Platysiphonia miniata and Cottoniella filamentosa
Autor: M F, Moghaddam, W H, Gerwick, D L, Ballantine
Publikováno v: The Journal of biological chemistry. 265(11)
The insulin release enhancer, 10-hydroxy-11,12-trans-epoxy-5(Z),8(Z),14(Z)-icosatrienoic acid (hepoxilin B3), is a 12-lipoxygenase metabolite of arachidonic acid that has been found in various mammalian tissues. Although lipoxygenase pathways are wel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::19fc390691b3266019e68c0baf4dd94f
https://pubmed.ncbi.nlm.nih.gov/2180942
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