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Autor:
Werner F. Fleck, K. Dornberger, R. Schlegel, W. Gutsche, E. F. Paulus, Udo Graefe, Michael Ritzau, Wolfgang Ihn, Albert Haertl, C. Stengel
Publikováno v:
ChemInform. 26
Publikováno v:
ChemInform. 29
Publikováno v:
Cancer Letters. 54:119-124
Dihydroambazone (DHA) is a water-soluble derivative of the experimental anticancer drug ambazone [8]. In vitro, a combination of DHA and human recombinant tumor necrosis factor alpha (TNF) exerted a strong synergism of cytotoxicity against both mouse
Autor:
Werner F. Fleck, Michael Ritzau, W. Gutsche, Udo Gräfe, Klausjürgen Dornberger, Regine Vettermann
Publikováno v:
The Journal of Antibiotics. 50:791-793
Publikováno v:
Arzneimittel-Forschung. 47(5)
The cytotoxin P4 from the venom of the cobra snake Naja nigricollis was examined for activity against aerobic gram-positive and gram-negative bacteria, yeasts, fungi and eucaryotic cell lines by determination of minimal inhibitory concentrations (MIC
Autor:
Schlegel Rolf, Michael Ritzau, Udo Gräfe, Wolfgang Ihn, Albert Härtl, Werner F. Fleck, W. Gutsche, Klausjürgen Dornberger, C. Stengel, E. F. Paulus
Publikováno v:
The Journal of antibiotics. 48(2)
Aurantimycins A (1), B (2) and C (3) were isolated from the mycelium of Streptomyces aurantiacus JA 4570 as new representatives of the azinothricin group of hexadepsipeptide antibiotics. Their structures were settled by X-ray diffraction analysis of
Autor:
K, Gase, V G, Korobko, H G, Wisniewski, J, Le, V N, Dobrynin, S A, Filippov, W, Gutsche, Y N, Maksimova, B, Schlott, L N, Shingarova
Publikováno v:
Immunology. 71(3)
Alterations of the C-terminal amino acid sequence of human tumour necrosis factor-alpha (hTNF-alpha) caused significant changes in its biological activity. Thus shortening of the C-terminus by removal of two or three amino acids led to a very marked
Publikováno v:
Die Pharmazie. 45(9)
Using two groups of substances (derivatives of 1,4-benzoquinone and azomethines) it was compared their effect on the microtubule formation in vitro and on experimental leukemias. 9 from the 28 substances tested acted cancerostatically, 4 substances i
Autor:
Albrecht Messerschmidt, Günter Burckhardt, Werner F. Fleck, Helmut Hanschmann, Wolfgang Römer, Joachim Baumgart, Walter Werner, W. Gutsche, Klaus Geller, D. Tresselt, Günter Löber
Publikováno v:
Biophysical chemistry. 35(2-3)
As an alternative to naturally occurring pyrrolo[2,1- c ][1,4]benzodiazepines (e.g., antramycin) which possess properties of DNA alkylation, we have designed several antileukemic chromeno[4,3- b ][1,5]benzodiazepine derivatives with potential activit