Zobrazeno 1 - 10
of 1 568
pro vyhledávání: '"W. Gruber"'
Autor:
Issa Onimisi Bello, Buniyamin A. Ayinde, Josephine O. Ofeimun, Fabian C. Amaechina, Nurkhalida Kamal, Christian W. Gruber, Enitome E. Bafor
Publikováno v:
Scientific African, Vol 25, Iss , Pp e02298- (2024)
Dysfunctional labour (DL) is a major cause of maternal and neonatal deaths worldwide. The only clinically available drug is oxytocin which is about 50% effective. Therefore, the development of new effective drugs for DL is a necessity. The medicinal
Externí odkaz:
https://doaj.org/article/720d6f48d9c6461db404cf3482780735
Autor:
Raphael Rossmanith, Kai Sauerwein, Christoph B. Geier, Alexander Leiss-Piller, Roman F. Stemberger, Svetlana Sharapova, Robert W. Gruber, Helmut Bergler, James W. Verbsky, Krisztian Csomos, Jolan E. Walter, Hermann M. Wolf
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundTrichothiodystrophy-1 (TTD1) is an autosomal-recessive disease and caused by mutations in ERCC2, a gene coding for a subunit of the TFIIH transcription and nucleotide-excision repair (NER) factor. In almost half of these patients infectious
Externí odkaz:
https://doaj.org/article/1b5d1168f41441349e90021ee7aec36e
Autor:
Miroslav Kosar, Roman C. Sarott, David A. Sykes, Alexander E. G. Viray, Rosa Maria Vitale, Nataša Tomašević, Xiaoting Li, Rudolf L. Z. Ganzoni, Bilal Kicin, Lisa Reichert, Kacper J. Patej, Uxía Gómez-Bouzó, Wolfgang Guba, Peter J. McCormick, Tian Hua, Christian W. Gruber, Dmitry B. Veprintsev, James A. Frank, Uwe Grether, Erick M. Carreira
Publikováno v:
ACS Central Science, Vol 10, Iss 5, Pp 956-968 (2024)
Externí odkaz:
https://doaj.org/article/a9641dd9dece4c6580e5b5242c4407b7
Autor:
Edin Muratspahić, Kristine Deibler, Jianming Han, Nataša Tomašević, Kirtikumar B. Jadhav, Aina-Leonor Olivé-Marti, Nadine Hochrainer, Roland Hellinger, Johannes Koehbach, Jonathan F. Fay, Mohammad Homaidur Rahman, Lamees Hegazy, Timothy W. Craven, Balazs R. Varga, Gaurav Bhardwaj, Kevin Appourchaux, Susruta Majumdar, Markus Muttenthaler, Parisa Hosseinzadeh, David J. Craik, Mariana Spetea, Tao Che, David Baker, Christian W. Gruber
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Despite the increasing number of GPCR structures and recent advances in peptide design, the development of efficient technologies allowing rational design of high-affinity peptide ligands for single GPCRs remains an unmet challenge. Here, we
Externí odkaz:
https://doaj.org/article/1f201974b4984c89a23ccc2a9cfd522a
Autor:
Francesca Nuti, Maud Larregola, Agnieszka Staśkiewicz, Bernhard Retzl, Nataša Tomašević, Lorenzo Macchia, Maria E. Street, Michał Jewgiński, Olivier Lequin, Rafal Latajka, Paolo Rovero, Christian W. Gruber, Michael Chorev, Anna Maria Papini
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Oxytocin (OT) is a neurohypophyseal peptide hormone containing a disulphide-bridged pseudocyclic conformation. The biomedical use of OT peptides is limited amongst others by disadvantageous pharmacokinetic parameters. To increase the stability of OT
Externí odkaz:
https://doaj.org/article/5e89b8ca7f1645cab06fcfd921debf44
Autor:
Mohammad Sadegh Taghizadeh, Bernhard Retzl, Edin Muratspahić, Christoph Trenk, Emilio Casanova, Ali Moghadam, Alireza Afsharifar, Ali Niazi, Christian W. Gruber
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The cholecystokinin-2 receptor (CCK2R) is a G protein-coupled receptor (GPCR) that is expressed in peripheral tissues and the central nervous system and constitutes a promising target for drug development in several diseases, such as gastroi
Externí odkaz:
https://doaj.org/article/f3aa175639b547bd888cae3111ba4c3b
Autor:
Judith Lind, Roland Hellinger, Petra Kudweis, Herwig P. Moll, Jasmin Gattringer, Kathrin Thell, Sophie Edtmayer, Christian W. Gruber, Dagmar Stoiber, Karoline Kollmann
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113486- (2022)
Ribosomally synthesized and post-translationally modified peptides, such as plant cyclotides, are a diverse group of natural products well known as templates in drug discovery and therapeutic lead development. The cyclotide kalata B1 (kB1) has previo
Externí odkaz:
https://doaj.org/article/c3573e6a9799417c98a50bb07321182e
Autor:
Chiara Madlen Falanga, Carmen Steinborn, Edin Muratspahić, Amy Marisa Zimmermann-Klemd, Moritz Winker, Liselotte Krenn, Roman Huber, Christian W. Gruber, Carsten Gründemann
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 152, Iss , Pp 113120- (2022)
Circular peptides are attractive lead compounds for drug development; this study investigates the immunomodulatory effects of defined root powder extracts and isolated peptides (called cyclotides) from Carapichea ipecacuanha (Brot.) L. Andersson (‘
Externí odkaz:
https://doaj.org/article/bb5fa6d74a3a4ad1bed8e8f0c4174973
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Since viral infectious diseases continue to be a global health threat, new antiviral drugs are urgently needed. A unique class of therapeutic compounds are antimicrobial peptides (AMPs). They can be found in humans, bacteria and plants. Plants expres
Externí odkaz:
https://doaj.org/article/546b9d9812584f478c48eddcda9abf10
Autor:
Edin Muratspahić, Bernhard Retzl, Leopold Duerrauer, Michael Freissmuth, Christian F. W. Becker, Christian W. Gruber
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Over the past years, peptides have attracted increasing interest for G protein-coupled receptor (GPCR) drug discovery and development. Peptides occupy a unique chemical space that is not easily accessible for small molecules and antibodies and provid
Externí odkaz:
https://doaj.org/article/5661f3ebca6742579c20e4afca40ca26