Zobrazeno 1 - 10
of 32
pro vyhledávání: '"W. Grimmett"'
Autor:
Thomas A. Packard, Roland Schwarzer, Eytan Herzig, Deepashri Rao, Xiaoyu Luo, Johanne H. Egedal, Feng Hsiao, Marek Widera, Judd F. Hultquist, Zachary W. Grimmett, Ronald J. Messer, Nevan J. Krogan, Steven G. Deeks, Nadia R. Roan, Ulf Dittmer, Kim J. Hasenkrug, Warner C. Greene
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT HIV infects long-lived CD4 memory T cells, establishing a latent viral reservoir that necessitates lifelong antiretroviral therapy (ART). How this reservoir is formed so quickly after infection remains unclear. We now show the innate inflamm
Externí odkaz:
https://doaj.org/article/0c31ebd503514659ba779d1be8395425
Autor:
Megan Pophal, Zachary W. Grimmett, Clara Chu, Seunghee Margevicius, Thomas Raffay, Kristie Ross, Anjum Jafri, Olivia Giddings, Jonathan S. Stamler, Benjamin Gaston, James D. Reynolds
Publikováno v:
Antioxidants, Vol 10, Iss 10, p 1527 (2021)
Thiol-NO adducts such as S-nitrosoglutathione (GSNO) are endogenous bronchodilators in human airways. Decreased airway S-nitrosothiol concentrations are associated with asthma. Nitric oxide (NO), a breakdown product of GSNO, is measured in exhaled br
Externí odkaz:
https://doaj.org/article/d1a130a4543a4d1bb3d6263a060b364e
Autor:
Thomas Raffay, Clara Chu, Jonathan S. Stamler, Megan Pophal, Kristie Ross, Anjum Jafri, Seunghee Margevicius, Benjamin Gaston, Zachary W. Grimmett, James D. Reynolds, Olivia Giddings
Publikováno v:
Antioxidants
Volume 10
Issue 10
Antioxidants, Vol 10, Iss 1527, p 1527 (2021)
Volume 10
Issue 10
Antioxidants, Vol 10, Iss 1527, p 1527 (2021)
Thiol-NO adducts such as S-nitrosoglutathione (GSNO) are endogenous bronchodilators in human airways. Decreased airway S-nitrosothiol concentrations are associated with asthma. Nitric oxide (NO), a breakdown product of GSNO, is measured in exhaled br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b4cab949a8953e72b1cf85bc919edb
Autor:
Fabio V. Fonseca, Thomas M. Raffay, Kunhong Xiao, Precious J. McLaughlin, Zhaoxia Qian, Zachary W. Grimmett, Naoko Adachi, Benlian Wang, Alfred Hausladen, Brian A. Cobb, Rongli Zhang, Douglas T. Hess, Benjamin Gaston, Nevin A. Lambert, James D. Reynolds, Richard T. Premont, Jonathan S. Stamler
Publikováno v:
Molecular Cell. 82:3089-3102.e7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96aa1e27b9c4a352dba6c4621f2b3383
https://doi.org/10.1016/j.molcel.2022.06.033
https://doi.org/10.1016/j.molcel.2022.06.033
Evaluating a New Class of AKT/mTOR Activators for HIV Latency-Reversing Activity Ex Vivo and In Vivo
Autor:
Emilie Besnard, Timothy J. Henrich, Warner C. Greene, Melanie Ott, Jacob D. Estes, William Brantley, Danielle M. Rosenthal, Nevan J. Krogan, Benjamin Varco-Merth, Michael Snape, Satish K. Pillai, Zachary W. Grimmett, Jeffrey D. Lifson, Hannah S. Sperber, Steven G. Deeks, Louise E. Hogan, Louis J. Picker, Michael Nekorchuk, Mark Connors, Stephen A. Migueles, Roland Schwarzer, Bernard Kiernan, Feng Hsiao, Thomas A. Packard, Jeffrey R. Johnson, Philip A. Hull, Nadia R. Roan, Mauricio Montano, Afam A. Okoye, Andrea Gramatica, Eytan Herzig, Eric Verdin
Publikováno v:
Journal of Virology. 95
An ability to activate latent HIV-1 expression could benefit many HIV cure strategies, but the first generation of latency reversing agents (LRAs) has proven disappointing. We evaluated AKT/mTOR activators as a potential new class of LRAs. Two glycog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49ee96ad24683ab5bdc46582429cd47
https://doi.org/10.1128/jvi.02393-20
https://doi.org/10.1128/jvi.02393-20
Autor:
Fabio V, Fonseca, Thomas M, Raffay, Kunhong, Xiao, Precious J, McLaughlin, Zhaoxia, Qian, Zachary W, Grimmett, Naoko, Adachi, Benlian, Wang, Alfred, Hausladen, Brian A, Cobb, Rongli, Zhang, Douglas T, Hess, Benjamin, Gaston, Nevin A, Lambert, James D, Reynolds, Richard T, Premont, Jonathan S, Stamler
Publikováno v:
Molecular cell. 82(16)
The β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b0c12777faaead639349a3321e0cddd
https://pubmed.ncbi.nlm.nih.gov/36109317
https://pubmed.ncbi.nlm.nih.gov/36109317
Autor:
Zachary W. Grimmett, Xiaoyu Luo, Eytan Herzig, Warner C. Greene, Schwarzer R, Marek Widera, Nevan J. Krogan, Steve Deeks, Hsiao F, Kim J. Hasenkrug, Ulf Dittmer, Judd F. Hultquist, Egedal Jh, Nadia R. Roan, Thomas A. Packard, Deepashri Rao, Ronald J. Messer
HIV infects long-lived CD4 memory T cells establishing a latent viral reservoir that necessitates lifelong anti-retroviral therapy (ART). How this reservoir is formed so swiftly remains unknown. We now show the innate inflammatory response to HIV inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19c2d7c62595ae388990115273308dbd
https://doi.org/10.1101/2021.02.25.432826
https://doi.org/10.1101/2021.02.25.432826
Autor:
Andrea, Gramatica, Roland, Schwarzer, William, Brantley, Benjamin, Varco-Merth, Hannah S, Sperber, Philip A, Hull, Mauricio, Montano, Stephen A, Migueles, Danielle, Rosenthal, Louise E, Hogan, Jeffrey R, Johnson, Thomas A, Packard, Zachary W, Grimmett, Eytan, Herzig, Emilie, Besnard, Michael, Nekorchuk, Feng, Hsiao, Steven G, Deeks, Michael, Snape, Bernard, Kiernan, Nadia R, Roan, Jeffrey D, Lifson, Jacob D, Estes, Louis J, Picker, Eric, Verdin, Nevan J, Krogan, Timothy J, Henrich, Mark, Connors, Melanie, Ott, Satish K, Pillai, Afam A, Okoye, Warner C, Greene
Publikováno v:
J Virol
An ability to activate latent human immunodeficiency virus type 1 (HIV-1) expression could benefit many HIV cure strategies; however, most latency-reversing agents (LRAs) have proven disappointing. We evaluated AKT/mTOR activators as a potential new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ac73e379a2961c197b973a74ab387bc0
https://pubmed.ncbi.nlm.nih.gov/33536176
https://pubmed.ncbi.nlm.nih.gov/33536176
Publikováno v:
The journal of cardiovascular aging
S-nitrosoglutathione reductase (GSNOR) is a denitrosylase enzyme responsible for reverting protein S-nitrosylation (SNO). In this issue, Salerno et al. [1] provide evidence that GSNOR deficiency - and thus elevated protein S-nitrosylation - accelerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60683bce77ba81d5fb6e77d537cc7a72
https://doi.org/10.20517/jca.2021.25
https://doi.org/10.20517/jca.2021.25
Autor:
Juraj Adamik, Gilad Doitsh, Warner C. Greene, Deborah L. Galson, Nicole L. K. Galloway, Sree H Pulugulla, Philip E. Auron, Thomas A. Packard, Zachary W. Grimmett
Publikováno v:
Cytokine. 111:373-381
Interleukin 1β is a pro-inflammatory cytokine important for both normal immune responses and chronic inflammatory diseases. The regulation of the 31 kDa proIL-1β precursor coded by the IL1B gene has been extensively studied in myeloid cells, but no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574f9ed10162155ef8cf000d6fdb2e65
https://doi.org/10.1016/j.cyto.2018.10.001
https://doi.org/10.1016/j.cyto.2018.10.001